ISSN:
1524-475X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Despite the use of antibiotics, antiseptics, and improved sterile techniques, infection remains one of the most frequent complications of wound healing. Infection must be avoided to permit proper wound healing. Systemic and topical antibiotics and antiseptics with broad antimicrobial spectra have been used. Antiseptics have not generally been reported to develop bacterial resistance like antibiotics. Several reports have suggested that antiseptics exhibit significant cytotoxicity toward wound bed cells and may interfere with the normal wound healing process. Thus, for chronic ulcers, the standard of care is debridment and moist dressing with saline.We will describe the properties of a new topical antimicrobial solution, NVC-101. These include its broad-spectrum antimicrobial activities against gram positive, gram negative bacteria, yeast and fungi pathogens, and its lower toxicity as compared to commonly used topical antiseptics. In addition, we will describe the in vivo safety profile of NVC-101 in the rabbit eye and guinea pig sensitization models, as well as 28-day application to full thickness wounds in rats and mini-pigs. Based on these findings, multicenter Phase II clinical trials on infected chronic ulcers are under way.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1067-1927.2005.130215cc.x
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