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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2694-2696 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 39 (1947), S. 830-837 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 23 (1984), S. 1953-1957 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 19 (1980), S. 956-959 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Carcinoma-in-situ (CIS) of the testis is known to be the pre-invasive stage of most human germ cell tumours (seminoma and non-seminoma), but the mechanisms leading to an increased pubertal proliferation of CIS cells after a long latency and to progression of CIS to an invasive malignancy are still not known. Additionally, CIS and seminoma have also been reported in equine testis (Veeramachaneni and Sawyer, 1998). The gap junctional protein and tumour suppressor gene connexin(cx)43 represents the predominant cx in human, canine and rodent testis so far and it is expected to play a key role for the regulation of both proliferation and differentiation of germ cells (spermatogonia and spermatocytes), and its gene- and protein-expression pattern is typical for the pubertal terminal differentiation of somatic Sertoli cells. Using cDNA-microarray analysis, in-situ hybridization (ISH), RT-PCR from tissue homogenate and semi-quantitative RT-PCR from well defined microdissected tubules with normal spermatogenesis, CIS, intratubular seminoma (ISe) and from seminoma cells from invasive seminoma we found a downregulation of cx43 starting in intratubular CIS, leading to a complete loss in most invasive seminoma cells. This indicates that regulation of cx43 expression takes place at transcriptional level confirming and expanding earlier studies of protein expression (Brehm et al., 2002). This reduction of cx43-expression suggests that an early intratubular derangement in cx43-gene expression and disruption of inter-cellular communication between Sertoli cells and/or Sertoli cells and pre-invasive tumour cells via cx43-gap junctions may play a role in the proliferation of CIS cells and seminoma cells and in the progression phase of testicular seminoma development.References  Veeramachaneni, D. N., and H. R.Sawyer, 1998: Carcinoma in situ and seminoma in equine testis. APMIS 106, 183–185.Brehm R., A. Marks, R. Rey, S. Kliesch, M. Bergmann and K. Steger, 2002: Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. J. Pathol. 197, 647–653.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 26 (1964), S. 479-483 
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The psychical symptoms accompanying troubles of the thyroid gland which belong to the endocrine syndrome fade away after a successful treatment, in close relation of time with the physical symptoms. A progressive recovery from the psychical trouble or, on the contrary, a persistence of the deviations for weeks, are part of the usual picture. However, a longer persistence of the psychopathological phenomenons after a physical recovery, above all, if there are symptoms of a depressive state of ill-humor, indicate a secondary disease. According to our observations, one must, above all, take into consideration the phasic psychoses, but also other troubles, as it is shown by the example of the woman-patient suffering from progressive Parkinson's disease. Independently of the complex problems of the pathogenic connections which present themselves in every particular case, our investigations furnish indications for the evaluation of the psychopathological symptoms of the troubles of the thyroid gland.
    Abstract: Résumé Les symptômes psychiques accompagnant des maladies de la glande thyroïde qui appartiennent au syndrome endocrine diminuent après un traitement couronné de succès, en étroite relation de temps avec les symptômes physiques. Un rétablissement progressif du trouble psychique ou, au contraire, une persistance des déviations pendant des semaines font partie de l'image usuelle. Pourtant, une persistance plus longue des phénomènes psychopathologiques après un rétablissement physique, surtout s'il y a des symptômes d'un état dépressif de mauvaise humeur, indique une maladie secondaire. D'après nos observations, il faut surtout prendre en considération des psychoses phasiques, mais aussi d'autres maladies, comme le montre l'exemple de la patiente souffrant de la maladie de Parkinson progressive. Indépendamment des problèmes complexes des connexions pathogéniques qui se présentent dans chaque cas particulier, nos recherches fournissent des indications pour l'évaluation des symptômes psychopathologiques des maladies de la glande thyroïde.
    Notes: Zusammenfassung Die in das endokrine Psychosyndrom gehörige psychische Begleitsymptomatik bei Schilddrüsenerkrankungen klingt nach erfolgreicher Therapie in engem zeitlichem Zusammenhang mit den körperlichen Krankheitszeichen ab. Eine voraneilende Besserung der psychischen Störungen oder aber ein Überdauern der Abweichungen um Wochen gehört zum gewöhnlichen Bild. Dagegen spricht eine längere Persistenz psychopathologischer Phänomene nach körperlicher Besserung, insbesondere, wenn sie die Symptomatik eines depressiven Verstimmungszustandes aufweisen, für eine Zweiterkrankung. Nach unseren Beobachtungen sind dann in erster Linie phasische Psychosen, aber wie das Beispiel der Patientin mit einem progredienten Parkinson zeigt, auch andere Erkrankungen in Betracht zu ziehen. Unabhängig von der komplexen, sich in jedem Einzelfall neu stellenden Problematik pathogenetischer Zusammenhänge, ergeben sich aus unseren Untersuchungen Hinweise für die Bewertung psychopathologischer Symptome bei Schilddrüsenerkrankungen.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Aequationes mathematicae 23 (1981), S. 169-174 
    ISSN: 1420-8903
    Keywords: Primary15A63,10C01 ; Secondary39B99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Chronic and acute phase of CML ; Chromosomal findings ; Clinical course
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to relate karyotype evolution to clinical and hematological data serial chromosomal analyses were performed in 31 patients with chronic myeloid leukemia (CML), both in chronic and acute phases. Our results in Philadelphia chromosome (Ph1)-positive CML are in line with karyotype profiles described in the literature. In addition, we report on chromosomal findings in 4 cases of Ph1-negative disease, one presenting with an iso17q chromosome in the acute phase, an aberration otherwise typical for acute transformation in Ph1-positive CML. The same chromosomal abnormality was observed in a small population of Ph1-negative cells present in one of two patients with mixed Ph1-positive/Ph1-negative CML. The first case of a female patient with the loss of a sex chromosome in Ph1-positive cells is reported. Two patients with unusually long and mild chronic phases despite the presence of trisomy 8 in their karyotypes are described. Our findings suggest that the order of appearance of additional chromosomal changes of CML is of prognostic significance for the progression and the clinical picture of the disease.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 257-261 
    ISSN: 1432-1440
    Keywords: Adverse effects ; Drug therapy ; Testicular neoplasms ; Critical care ; Hodentumoren ; Polychemotherapie ; Nebenwirkungen ; supportive Maßnahmen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 25 Patienten mit metastasierten, nicht-seminomatösen Hodentumoren wurden operiert und zytostatisch mit einer Kombination aus Velbe, Bleomycin, Cis-Platin und/oder Ifosfamid behandelt. In 22 Fällen konnte eine anhaltende Vollremission bei einer mittleren Beobachtungszeit von 23 Monaten erreicht werden. 2 Patienten verstarben durch einen rasch auftretenden Tumorprogreß an postoperativen Komplikationen nach Second-look-LA. Ein Patient erlag nach Chemotherapie einem septischen Schock. Die Morbidität dieser effektiven Chemotherapie darf nicht unterschätzt werden. Passagere Panmyelophtise, Anorexie, Alopezie und Hyperpigmentationen sind unvermeidbar. Schweres Erbrechen, Elektrolytentgleisung, hämorrhagische Cystitis, Anämie, Septikämien lassen sich durch supportive Maßnahmen reduzieren. Auftretende Septikämien sind durch eine geeignete Antibiotika-Kombination ohne zusätzlichen Tubulusschaden zu beherrschen. Schwerwiegende Dauerschäden insbesondere an Innenohr und Niere können vermieden werden.
    Notes: Summary 25 Patients with metastatic non-seminomatous testicular neoplasms were treated by surgery and cytostatic therapy using a combination consisting of Velban, Bleomycin, Cis-Platinum and/or Ifosfamid. In 22 patients this procedure induced a persistant complete remission with a mean observation time of 23 months. 2 patients died because of post-surgical complications after a second-look-lymphadenectomy. They suffered from rapidly progressive tumor disease. One patient died in a septicemia during chemotherapy. Our experience is that morbidity of an effective chemotherapy should not be underestimated. Transient bone marrow suppression, anorexia, alopecia and hyperpigmentation are unavoidable. However, severe vomiting, disturbed electrolyte metabolism, hemorrhagic cystitis, anemia and septicemia can well be managed by respective supportive care. Septicemia, for instance, may be treated with appropriate antibiotics without inducing tubular necrosis. Supportive measures also will avoid severe chronic defects of ear and kidney function.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für angewandte Mathematik und Physik 15 (1964), S. 655-658 
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
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