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  • 1
    Electronic Resource
    Electronic Resource
    Terminal deoxynucleotidyl transferase-positive cells in trephine biopsies following bone marrow or peripheral stem cell transplantation reflect vigorous B-cell generation (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : Bone marrow is the major site of B-cell generation in humans. While in early childhood a high number of B-cell precursors is found in the bone marrow, only very few such cells are usually detectable in adult bone marrow. To assess the number of immature B cells present after haematopoietic cell transplantation the number of terminal deoxynucleotidyl transferase (TdT)-positive cells in regenerating bone marrow of adult patients was analysed.Methods and results : Bone marrow biopsy specimens were analysed from patients after allogeneic bone marrow transplantation (BMT; n = 14) or stem cell transplantation (SCT; n = 25) and autologous BMT (n = 9). Specimens from 11 untransplanted adult patients and 11 infants were also studied, as negative and positive controls, respectively. Immunohistochemistry was performed on paraffin-embedded bone marrow biopsy sections using TdT as a marker of lymphoid progenitors. Immunoreactivity for CD79a, CD20 and CD10 was used to confirm their B-cell origin. Using computer-assisted automated image analysis we quantitatively assessed the TdT+ cells present. We found a significant increase in the numbers of B-cell precursors in the bone marrow after allogeneic and autologous BMT/SCT compared with adult controls (P = 0.022). To analyse this in detail, we followed some patients after allogeneic BMT/SCT for up to 1445 days, when a marked B-cell increase was still detectable. However, the median number of TdT+ B cells after BMT/SCT was significantly lower than the number of equivalent B cells in infantile bone marrow biopsy specimens (P 〈 0.001).Conclusions : Bone marrow of adult patients after BMT/SCT is capable of initiating vigorous precursor B-cell generation, which is not seen in untransplanted adults. However, the increase of immature B cells was variable in our study. Only in two young adult patients did it reach the magnitude of B-cell generation seen in infantile bone marrow where immunocompetent B cells are produced normally. A marked increase in number of immature B cells post-transplant may mimic B-cell acute lymphoblastic leukaemia (B-ALL). This is a potential problem in patients transplanted for B-ALL itself. Since reactive and neoplastic B-cell precursors share the same immunophenotype in paraffin-embedded tissue, additional tools, particularly molecular techniques, may have to be employed to establish the correct diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02109.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low-grade intraepithelial neoplasia of Brunner's gland (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02066.x
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  • 3
    Electronic Resource
    Electronic Resource
    248. Weichgewebstumoren: Pathologie and Klinik (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 620-621 
    Details
    ISSN: 1435-2451
    Keywords: Soft tissue tumors ; Incidence ; Grading and classification ; Weichgewebstumoren ; Häufigkeit ; Graduierung und Klassifizierung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Weichgewebstumoren machten ca. 2,8 % unseres gesamten chirurgischen Einsendungsmaterials aus. Am häufigsten fanden sich dabei Tumoren des Fett- und Bindegewebes. Bei den letzteren sind die agrressive Fibromatose und die noduläre Fasciitis von besonderem klinisch-pathologischem Interesse. Durch eine kombinierte Beurteilung der histologischen Graduierung und der histogenetischen Klassifizierung kann das TNM/G-System angewandt werden, woraus sich auch eine Stadieneinteilung ergibt. Die Unterscheidung von geringem und hohem Malignitätsgrad ist die Voraussetzung einer optimalen Therapie von Sarkomen.
    Notes: Summary Soft tissue tumors showed an overall incidence of 2.8% in our surgical material. Most frequently found were tumors of fatty or connective tissues. In the latter, aggressive fibromatosis and nodular fasciitis are of special clinical-pathological interest. By combined consideration of a histological grading and histogenetic classification the TNM/G-system can be applied with consecutive staging. Distinction between low- or highgrade malignancy is a prerequisite for an optimal therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287081
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  • 4
    Electronic Resource
    Electronic Resource
    205. Sarkome des fibrösen und lipomatösen Weichteilgewebes. Bioptische Diagnostik und statistische Analyse (1981)
    Springer
    Langenbeck's archives of surgery 355 (1981), S. 564-564 
    Details
    ISSN: 1435-2451
    Keywords: Fibrous sarcomas ; Liposarcomas ; Surgical pathology ; Fibröse Sarkome ; Liposarkome ; Klinische Pathologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 55% aller malignen Weichgewebsgeschwülste unseres Materials (1478 benigne und 322 maligne Weichteiltumoren) betreffen fibröse und lipomatöse Sarkome (i.e. Liposarkom, malignes fibröses Histiocytom, Fibrosarkom, Dermatofibrosarcoma protuberans). Zahlenmäßig führen Liposarkome (19,9%), es folgen Histiocytome (12,7 %), Fibrosarkome (11,5 %) und Dermatofibrosarkome (10,9 %). Sowohl auf die Tumormorphe einschließlich der prognostisch günstigen myxoiden Varianten, als auch auf Alters- und Lokalisationsverteilung sowie Rezidivhäufigkeit wurde detailliert eingegangen.
    Notes: Summary In our material (1478 benign tumors, 322 malignant ones) 55% of the malignant soft tissue tumors were made up by sarcomas of the fibrous and adipose tissue. In order of frequency, we found among these neoplasms liposarcoma (19.9%), malignant fibrous histiocytoma (12.7%), fibrosarcoma (11.5%), and dermatofibrosarcoma protuberans (10.9%).The morphological pictures were demonstrated, especially myxoid subtypes with favorable prognosis. In addition the distribution of age, the anatomical location, and the account of recurrences were reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287035
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  • 5
    Electronic Resource
    Electronic Resource
    Neutron and light-charged-particle productions in proton-induced reactions on 208Pb at 62.9 MeV (2005)
    Springer
    The European physical journal 23 (2005), S. 49-60 
    Details
    ISSN: 1434-601X
    Keywords: 27.80.+w 190 ⩽ A ⩽ 219 ; 25.40.-h Nucleon-induced reactions ; 25.40.Sc Spallation reactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Neutrons and light charged particles produced in 62.9MeV proton-induced reactions on 208Pb were measured during a single experiment performed at the CYCLONE facility in Louvain-la-Neuve (Belgium). Two independent experimental set-ups were used to extract double differential cross-sections for neutrons, protons, deuterons, tritons, 3He and alpha-particles. Charged particles were detected using a set of Si- Si- CsI telescopes from 25° to 155°, by step of 10 degrees. Neutrons were measured using shielded DeMoN counters, liquid NE213 scintillators, at 24°, 35°, 55°, 80° and 120°. These data allowed the determination of angle differential, energy differential and total production cross-sections. A comparison with theoretical calculations (MCNPX, FLUKA and TALYS) has been performed. It shows that the neutron and proton production rates are well predicted by MCNPX, using the INCL4 option. All the other codes underestimate the neutron production whereas they overestimate the proton one. For composite particles, which represent 17% of the charged particle total reaction cross-section, neither the shape nor the amplitude of the cross-sections are correctly predicted by the models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epja/i2004-10073-1
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