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Induction of estrogen-independent persistent vaginal cornification in cyproterone acetate (CA)-induced feminized male mice (1977)

Suzuki, Y. ; Arai, Y.

Springer

Anatomy and embryology 151 (1977), S. 119-125

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ISSN: 1432-0568

Keywords: Feminized male mice ; Antiandrogen ; Neonatal estrogen treatment ; Estrogen-independent persistent vaginal cornification

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Pregnant ICR/JCL mice were treated with 6 mg of cyproterone acetate (CA) from days 14 to 20 of pregnancy to feminize male offspring. Feminized males delivered on day 20 of pregnancy by cesarean section were castrated the same day, injected with estradiol-17β(E2) or sesame oil from the day of delivery (=day 1) to day 10 and sacrificed on day 60. In oil-injected feminized males, the vaginal epithelium was atrophic and did not show cornification. In feminized males given 20 μg E2 neonatally, the vaginal epithelium exhibited well-differentiated stratified squamous organization, but was not cornified in seven out of the nine mice of this group. In the mice treated with 50 μg E2, persistent cornification was recognized most frequently in the posterior two-thirds of the vaginal epithelium which is considered to originate from the which may contain the epithelial cells of müllerian duct was low. These results provide supporting evidence for the possible participation of epithelial cells which come from the urogenital sinus in the development of estrogen-independent persistent vaginal cornification in neonatally estrogenized mice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00297475

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The effect of oxidation state on the intensities of Kβ5 and Kβ″ of 3d-transition elements (1975)

Asada, E. ; Takiguchi, T. ; Suzuki, Y.

New York, NY [u.a.] : Wiley-Blackwell

X-Ray Spectrometry 4 (1975), S. 186-189

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ISSN: 0049-8246

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Physics

Notes: Using a commercially available flat crystal spectrometer in a slightly modified form, an investigation was made of the peak intensity ratios (Kβ5/Kβ1) and the relative intensities of Kβ″ to Kβ5 in different oxidation states of 3d-transition metal atoms existing in forms of oxidic compounds. The peak intensity ratios (Kβ5/Kβ1) for V, Cr, Mn, Fe, Co, Ni and Cu, as well as the peak profiles of Kβ″ and Kβ5 for V, Cr and Mn, were investigated. Results suggest that changes in the intensities of the Kβ5 and Kβ″ bands can be applied to determining the oxidation number of a metal atom in its oxide.

Additional Material: 4 Ill.