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  • 2005-2009  (23)
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  • 1
    Electronic Resource
    Electronic Resource
    Brucella melitensis infection associated with Guillain–Barré syndrome through molecular mimicry of host structures (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 45 (2005), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Brucella melitensis is a facultative intracellular bacterium that can survive inside macrophages and the causative agent of brucellosis. In the present study, we found that a lipooligosaccharide of B. melitensis has a GM1 ganglioside-like structure and shows a strong antibody response in mice. The cholera toxin B subunit, which binds to GM1 ganglioside specifically, reacted with the surface of B. melitensis. Immunization with B. melitensis induced the production of anti-GM1 ganglioside antibodies in mice and serum from immunized mice showed a cross-reaction with Guillain–Barré syndrome (GBS)-associated Campylobacter jejuni, but not non-GBS-associated C. jejuni. When B. melitensis was treated with a neuraminidase, antibody responses disappeared. B. melitensis immunization induced the production of anti-GM1 ganglioside antibodies in BALB/c mice but not in C57BL/6 and ddY mice, and for BALB/c mice, immunization with B. melitensis induced much greater production of anti-GM1 ganglioside than GBS-associated C. jejuni. Flaccid limb weakness was observed in B. melitensis immunized mice. These results suggest that B. melitensis is a new etiological agent for GBS and that immunological responses between it and GBS-associated C. jejuni in the mouse model may be different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsim.2005.03.001
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of Emdogain〈sup〉®〈/sup〉 Treatment onto K〈sub〉2〈/sub〉O Incorporated Calcium Metaphosphate on Osteogenic Activation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 631-634 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: As a part of the efforts to develop a suitable scaffold optimizing bone regeneration that has similar physical properties to bone, we modified calcium metaphosphate (CMP) ceramics with K2O and evaluated their efficiency as a scaffold for tissue engineered bone tissue regeneration. Macroporous CMP ceramics modified by incorporation of 5% K2O to improve biodegradability were prepared to have 250 and 450 µm average pore sizes, respectively. The modified CMP ceramics werecultured with mouse primary calvarial osteoblastic cells in osteogenic media for 2 weeks and these cell-CMP ceramic constructs with or without Emdogain treatment were implanted in the SCID mice subcutaneous pouches. After 1, 2, and 3 weeks, the degree of ectopic bone formation was evaluated. The modified macroporous CMP ceramic-cell constructs treated with Emdogain induced ectopicbone formation, whereas the modified CMP ceramic-cell constructs without Emdogain treatment induced no ectopic bone formation. This result suggests that the Emdogain treatment on cell-scaffold constructs for tissue engineered bone regeneration may be effective for osteogenic activation of attached cells
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.631.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    A Simple but Effective Demineralizing Method for Osteogenic Allograft Preparation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 249-252 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone regeneration with demineralized bone preparations has demonstrated its potential in grafting procedures in surgical disciplines of both medicine and dentistry. To improve the effectiveness in preparation and osteogenic regeneration, we developed a simple and rapid demineralizing method for osteogenic allograft preparation and evaluated its osteogenic effect using an ectopic bone formation assay. The rat diaphyseal cortical bones were demineralized in heated 0.6N HCl at 60° C for 10 to 30 mins using a controlled-heat ultrasonic cleaner, washed withsterilized distill water, and dehydrated with graded alcohol after 30% H2O2 treatment. The prepared grafts were implanted in rat dorsal subcutaneous pouches for 1-3 weeks and then the harvested tissue samples were prepared for routine light microscopic observation. The allografts demineralized with 60°C HCl for more than 20 mins in an ultrasonic condition were completely demineralized and effectively induced ectopic formation without specific pathologic findings. These findings suggest that demineralization with 60°C HCl for around 20 mins using a controlled-heat ultrasonic cleaner and dehydration with graded alcohol after short treatment with 30% H2O2 is a very simple but effective osteogenic allograft preparation method with minimal antigenicity and sterilizing effects
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.249.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Improvement of Luminescent Properties of Phosphor Powders Coated with Nanoscaled SiO〈sub〉2〈/sub〉 by Atomic Layer Deposition (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 124-126 (June 2007), p. 375-378 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: An investigation is reported by coating BaMgAl10O17:Eu2+ phosphor by silicon oxide usingcatalyzed atomic layer deposition. Nanoscaled SiO2 films were prepared at room temperature usingtetraethoxysilane (TEOS), H2O and NH3 as precursors, reactant gas and catalyst, respectively. AESanalysis showed the surface composition of coated phosphor was silicon oxide. In TEM and FE-SEManalysis, the growth rate was about 0.7 Å/cycle and the surface morphology became smoother andclearer than that of uncoated phosphor. The photoluminescence intensity (PL) increased up to 11.04%as ALD cycle increased up to 200 ALD cycle. This means that the reactive surface of uncoatedphosphors is uniformly grown with stable silicon oxide to reduce the dead surface layer withoutchange of bulk properties. Moreover, it is found that nanoscaled SiO2 films are quite effective for theimprovement of the aging characteristics of photoluminescence
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.124-126.375.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    A Comparative Study of the Porous Structure of a Scaffold for Effective Tissue-Engineered Bone Regeneration (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 935-938 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To develop a suitable scaffold for tissue-engineered bone regeneration, we compared theefficiency of tissue-engineered bone regeneration according to the porous structure of calciummetaphosphate (CMP) ceramic scaffolds. Each scaffold was prepared with a sponge method and afoam-gel method, respectively. Both scaffolds, having either interconnected trabecular pores formedby the sponge method or fully interconnected globular pores formed by the foam-based technology,were not cytotoxic and elicited neither an immune nor an inflammatory response regardless ofgeometry and fabrication method. The fully interconnected globular porous scaffold showed morefavorable compression strength and facilitated osteogenic repair by favoring cellular attachment andosteogenic differentiation with good osteoconductivity compared to the interconnected trabecularpore structured scaffold. These results suggest that the fully interconnected globular porous structurewould be more suitable for both a bone substitute and scaffold for bioactive material-based orcell-based tissue bone regeneration
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.935.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of Bone Cell Behaviors on Collagen Grafted Hydroxyapatite Surfaces (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1143-1146 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In order to enhance bone cell adhesion on hydroxyapatite (HA), collagen was used as asurface-grafting material on HA substrates because the collagen is a major constituent ofconnective tissues and has been regarded as one of the most excellent coating materials for bonebonding. First, HA disks (10mmΦ x 1mm) were prepared and then collagen was immobilbized onthe HA surface using an 3-APTES coupling agent on HA disk surfaces. MC3T3-E1 osteoblastswere seeded on the collagen-grafted and non-grated HA disks and cultured in a Dulbecco’smodified eagle medium containing 10% fetal bovine serum for 4 hrs to evaluate the cell adhesionon the HA samples. The osteoblasts on the collagen-grafted sample were more spread than those onthe non-grafted sample. It is believed that collagen-grafted HA surface provides suitable sites forcell attaching due to the high biocompatibility of collagen
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1143.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Stimulatory Effect of Nano-Sized Calcium Metaphosphate Particles on Proliferation and Osteoblastic Differentiation of Human Bone Marrow Mesenchymal Stem Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1177-1180 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Recently, nanomaterials have received considerable attention because of their potentialapplications in the biomedical field. In the present study, we investigated the effects of nano-sizedcalcium metaphosphate (CMP) particles (50 nm) compared with micro-sized CMP particles (200-500nm and 10 μm) on the proliferation and osteoblastic differentiation of human bone marrow stem cells(BMSCs). BMSCs were challenged with CMP particles with different sizes for 3, 5, and 7 days. Ananalysis of the proliferation revealed that the nano-sized CMP particles (50 nm) stimulated theproliferation of BMSCs up to 27.79% compared to the untreated control. This stimulatory effect ofthe nano-sized CMP particle was dose-dependent. CMP particles appeared to adhere on the surface ofBMSCs but this did not cause distinguishable morphological changes. Moreover, all CMP particles(50 nm to 10 μm) were capable of stimulating an osteoblastic differentiation of BMSCs as accessedby alkaline phosphatase (ALP) and von Kossa stainings. Further molecular analysis revealed that allthe CMP particles induced an expression of osteoblast-related genes such as osteocalcin (OC) andcollagen I (Col I). Taken together, our data demonstrate that nano-sized CMP particles have thepotential to stimulate the proliferation and osteoblastic differentiation of BMSCs
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1177.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Preparation of Biodegradable Porous Calcium Metaphosphate Granules as Bone Filler by Starch Consolidation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 369-372 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Porous calcium metaphosphate granules for bone fillers were prepared by starchconsolidation with baking powder and surfactant. Paste for foaming was prepared by the mixing of calcium metaphosphate powder and water with the various amount of starch (10~20㎛ size), where solid contents 30%, 45%, 60% of the paste. In order to obtain the optimum micro/macro porous structure, the appropriate contents of baking powder and surfactant at a fixed content of starch wereexamined. In order to examine the content of baking powder on pore morphology, the baking powder was added 60, 180, and 300 wt% of the paste at fixed content of starch. And then, in order to investigate the effect of surfactant on porous structure, surfactant was added 0.035, 0.1, and 0.16 wt% of paste weight at fixed content of starch and baking powder. Foaming was conducted using microwave method, and foamed samples were sintered at 900 ºC. The sintered porous blocks withstarch only showed uneven and closed macro pores without any micro pores. However, the sintered porous blocks with starch, baking powder, and surfactant showed homogeneous micro and macro porous structures ranging 20~60, and 300~1000 ㎛ in pore size, respectively. The porosity was increased with the increase of surfactant up to about 70 %
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.369.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Development of Hydroxyapatite Thin Film on Titanium Substrate by Electrophoretic Deposition (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 901-904 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Electrophoretic deposition was used for HA coating on dental implants with differentcoating thickness. The HA coating thickness was examined in terms of applied voltage and time, and powder concentration in suspension. Nano-size HA and SiO2-CaO-P2O5-B2O3 bioglass powders were synthesized by sol-gel method. Polyvinyl alcohol (3 wt%) as a binder was resolved in ethyl alcohol, then, nano HA powder was dispersed ultrasonically in the mixture for 15 min and pH was adjusted with HNO3 for positive charging on particle. Titanium substrate was held on cathode and counter electrode was platinum. HA with 0.5 % and 0.03 % of powder concentration was deposited electrophoretically at 10~20 V for 1~20 minutes. The thickness of as-deposited HA layer decreased from nearly 80 µm (0.5 %, 20 V, 10 min) to 4~5 µm (0.03%, 10V, 1 min) as powder concentration, applied voltage and time decreased, respectively. The surface of HA coating layer deposited in lowerpowder concentration showed much more homogeneous and relatively dense morphology, in contrast, the surface in thick suspension became rough or porous and was easily spalled. In a co-deposition of HA and bioglass, co-deposited glass played an important role in increasing bonding strength between coating layer and substrate. It is believed that electrophoretic deposition method can be one ofalternatives for relatively thin and easy HA coating
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.901.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Tissue Engineered Bone Formation with Polymer/Ceramic Composites by Press-and-Baking Method (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 79-82 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel process was developed to fabricate polymer/ceramic composites for bonetissue engineering. The mixture of polylactic acid (PLA), calcium metaphosphate (CMP), and NaCl were compressed and subsequently heated. After dissolving the NaCl salts, porous biodegradable polymer/ceramic composite scaffolds were formed. The characteristics of the scaffolds were compared to those of scaffolds fabricated using a conventional solvent casting method, in terms of pore structure, pore size distribution, and mechanical properties. The scaffolds were seeded byosteoblasts and cultured in vitro or implanted into nude mice subcutaneously for up to 5 weeks. Cells were better grown to form tissue-like structures on CMP/PLA composites fabricated by the Press-and-Baking method. In addition, the alkaline phosphatase activity of and calcium deposition in the scaffolds explanted from mice were enhanced significantly for the scaffolds by Press-and-Baking compared to them by solvent casting. Taken together, these results suggest that CMP promote cell differentiation and proliferation via direct interaction with cells in the CMP/PLAcomposites. This novel PLA/CMP composite will be applicable for bone tissue engineering to support and cell differentiation and growth
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.79.pdf
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