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Comparison of hemostatic effects by route of H2 receptor antagonist administration following endoscopic mucosal resection in patients with neoplastic gastric lesions (2005)

Satoh, K. ; Yamamoto, H. ; Kawata, H. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Alimentary pharmacology & therapeutics 21 (2005), S. 0

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ISSN: 1365-2036

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Background : To date, there has not been an in-depth investigation to identify differences in the effects of bleeding prevention among different routes of administration of H2 receptor antagonists to treat gastric ulcers following endoscopic mucosal resection (EMR).Aim : To prospectively compare the frequency of bleeding following EMR between patients treated with intravenous(IV) famotidine and those with oral famotidine.Methods : Fifty-three patients with neoplastic gastric lesions (33 carcinoma and 20 adenoma) treated by EMR were included. Subjects underwent EMR with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate (EMRSH), followed by IV or oral (PO) administration of famotidine at a dosage of 40 mg/day for 2 days. Patients with odd ID numbers were assigned to IV therapy (30 cases) while even numbers were given PO therapy (23 cases). Frequencies and endoscopic findings of bleeding during the first 2 days after EMR were examined.Results : Frequency of bleeding within 2 days after EMR was 3 and 4% in IV and PO patients, respectively, showing no significant difference. No significant difference was seen in the endoscopic findings of bleeding and therapy, either, with respective IV and PO findings at 23 and 26%.Conclusions : No significant difference was observed in frequency of bleeding within 2 days after gastric EMR between IV and oral administrations of famotidine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02483.x

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Filler Network Change and Nonlinear Viscoelasticity of Rubbers (2006)

Isono, Yoshinobu ; Satoh, Y. ; Fujii, Shuji ; [et al.]

s.l. ; Stafa-Zurich, Switzerland

Advanced materials research Vol. 11-12 (Feb. 2006), p. 729-732

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ISSN: 1662-8985

Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Uncured, filled rubbers show remarkable nonlinear viscoelasticity as well as cured, filledrubbers. The nonlinearity may come from change in entanglement and filler network structures. Manypeople use dynamic modulus to characterize rubber materials. However, dynamic modulus cannot bedefined at large strain. Hence we must study a viscoelastic function to be defined at large strain. Inaddition, we need other information to separate the effects of the change in entanglement and fillernetwork structures on nonlinear viscoelasticity. In this work, we have measured simultaneouslyrelaxation modulus G(γ,t) and electrical resistivity ρ(γ,t) for carbon black (CB)-filled, uncuredstyrene-butadiene copolymers (SBRs) at wide range of strains. Electrical resistivity at equilibrium,ρ(0,t), showed step-like change at the CB loading between 20 and 35 phr, indicating threshold forfiller network formation should exist in the range of values in CB loading. Both G(γ,t) and ρ(γ,t) forthe samples having CB loading to be higher than the threshold showed nonlinearity at the strain largerthan shear strain γ=0.1, indicating rupture in filler network at large strain