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  • 1
    Electronic Resource
    Electronic Resource
    Angiotensin II further enhances type IV collagen production stimulated by platelet-derived growth factor and fibroblast growth factor-2 in cultured human mesangial cells (2000)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 5 (2000), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY: Angiotensin II (Ang II) is considered to play a role in the development of glomerulosclerosis, which is characterized by excessive accumulation of mesangial matrix after mesangial cell proliferation. We have reported that platelet-derived growth factor (PDGF) and fibroblast growth factor-2 (FGF-2) stimulate type IV collagen production by cultured human mesangial cells (HMC). Although Ang II is well known to have a mitogenic effect in various kinds of cells, its role in the production of extracellular matrix is still undetermined. This study was designed to examine the effect of Ang II and its interaction with PDGF and FGF-2 in type IV collagen production by HMC. Cultured HMC were incubated with Ang II with or without PDGF or FGF-2 for 72 h and type IV collagen, fibronectin and laminin in the cell supernatants were measured. Ang II (10−6–10−8) itself did not change the production of type IV collagen, fibronectin, laminin and transforming growth factor-β. PDGF and FGF-2 enhanced type IV production, although they did not stimulate the production of fibronectin and laminin. Ang II further increased the stimulating effect of PDGF and FGF-2 in type IV collagen production in a dose-dependent manner. This effect of Ang II was completely blocked by Ang II type I receptor antagonist (Losartan). These data imply that Ang II is a potent stimulator of type IV collagen production by HMC in the presence of growth factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.2000.00017.x
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine-2 receptor expression in gastric mucosa before and after Helicobacter pylori cure (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of Histamine-2 (H2) receptor antagonists. Gastro-esophageal reflux disease develops in some cases with the restoration of acid secretion after H. pylori eradication therapy.Aim : To clarify the mechanisms of H2 receptor restoration after the eradication of H. pylori on parietal cells.Methods:  We enrolled 80 consecutive asymptomatic male patients with H. pylori infection, having chronic gastritis with or without the presence of peptic ulcers. Biopsy specimens from the greater curvatures at the mid-corpus of the stomach were obtained endoscopically from all subjects before and 12 weeks after the eradication of H. pylori. Degrees of gastric atrophy were evaluated by serum pepsinogen levels. The amounts of mRNA expression of H2 receptor were evaluated in each subject's gastric mucosa by real time reverse transcriptase-polymerase chain reaction (RT-PCR).Results : H2 receptor mRNA expression levels significantly correlated with serum pepsinogens I and II ratios. The expression level of H2 receptor mRNA was lower in subjects with hypergastrinemia. The median expression level of H2 receptor after H. pylori eradication was threefold greater than prior to treatment. In addition, its restoration became more pronounced in subjects with severe gastric atrophy. However, a comparatively low restoration of H2 receptor mRNA was found in subjects with hypergastrinemia.Conclusions : H2 receptor mRNA levels decrease with the progression of gastric atrophy induced by H. pylori infection, and are restored after H. pylori eradication. Such expression levels of H2 receptor may explain a part of the tolerance phenomenon to H2 receptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02481.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of hemostatic effects by route of H2 receptor antagonist administration following endoscopic mucosal resection in patients with neoplastic gastric lesions (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : To date, there has not been an in-depth investigation to identify differences in the effects of bleeding prevention among different routes of administration of H2 receptor antagonists to treat gastric ulcers following endoscopic mucosal resection (EMR).Aim : To prospectively compare the frequency of bleeding following EMR between patients treated with intravenous(IV) famotidine and those with oral famotidine.Methods : Fifty-three patients with neoplastic gastric lesions (33 carcinoma and 20 adenoma) treated by EMR were included. Subjects underwent EMR with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate (EMRSH), followed by IV or oral (PO) administration of famotidine at a dosage of 40 mg/day for 2 days. Patients with odd ID numbers were assigned to IV therapy (30 cases) while even numbers were given PO therapy (23 cases). Frequencies and endoscopic findings of bleeding during the first 2 days after EMR were examined.Results : Frequency of bleeding within 2 days after EMR was 3 and 4% in IV and PO patients, respectively, showing no significant difference. No significant difference was seen in the endoscopic findings of bleeding and therapy, either, with respective IV and PO findings at 23 and 26%.Conclusions : No significant difference was observed in frequency of bleeding within 2 days after gastric EMR between IV and oral administrations of famotidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02483.x
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  • 4
    Electronic Resource
    Electronic Resource
    Chemistry of organosilicon compounds CLXXXIII. An ESR study on β-trimethylsilylamine-and related amine-N-oxyls. Unusual conformational preference of the β-silyl group
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 259 (1983), S. 51-63 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-328X(83)85156-0
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  • 5
    Electronic Resource
    Electronic Resource
    Radical ions - XXVIII. Tris(trimethylsilylmethyl)aminium, N(CH"2Si(CH"3)"3)"3: A stable fluxional aminium radical cation
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 164 (1979), S. 295-304 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0022-328X(00)81693-9
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  • 6
    Electronic Resource
    Electronic Resource
    Pilot study of continuous low-dose 5-fluorouracil and cisplatin (FP regimen) for the treatment of metastatic breast cancer (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 18-21 
    Details
    ISSN: 1437-7772
    Keywords: Key words Breast cancer ; 5-Fluorouracil ; Cisplatin ; Low-dose FP ; Anthracycline-resistant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The effect of low-dose 5-fluorouracil (FU) and cisplatin therapy (FP regimen) against metastatic breast cancer was investigated. Methods. A pilot study of the FP regimen was performed in 11 patients with metastatic breast carcinoma who had previously received chemotherapy, including adriamycin, and/or hormonal therapy. Their median age was 56 years (range, 48–72 years). Visceral metastases were present in all patients. FU, at a dose of 170 mg/m2 per day, was administered for 28 days by continuous intravenous infusion. Cisplatin (7 mg/m2 per day) was given intravenously on days 1–5, 8–12, 15–19, and 22–26. After a 2-week interval, this treatment was repeated. Results. Of the 11 patients assessable for tumor response to the FP regimen, 4 patients (36%; 95% confidence intervals [CI], 8%–64%) achieved an objective response, with 1 showing a complete response and 3 showing a partial response. Median time to progression was 6.5 months (range, 4–25 months). The median survival time from the initiation of the FP regimen was 11 months (range, 3–25 months). Gastrointestinal and hematologic toxicity was mild. Conclusion. The FP regimen is promising for and has acceptable tolerance in patients with metastatic breast carcinoma refractory to previous anthracycline-containing chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050004
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  • 7
    Electronic Resource
    Electronic Resource
    Interleukin 6 as a marker of mesangial cell proliferative activity (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 119-125 
    Details
    ISSN: 1437-7799
    Keywords: Key words Interleukin 6 ; Interleukin 6 receptor ; mesangial cell ; Proliferating cell nuclear antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The role of Interleukin 6 (IL-6) in the pathogenesis of mesangial proliferative glomerulonephritis has been controversial. To test the hypothesis that glomerular mesangial cell (GMC)-derived IL-6 may not be a mitogen for GMCs, but, rather, a factor that reflects GMC proliferative activity, we investigated how the culture condition; namely, cell confluency, affected IL-6 production in human cultured GMCs. Methods. IL-6 in the culture supernatant was measured by enzyme-linked immunoassay (ELISA). The expression of IL-6, IL-6 receptor (IL-6R), and proliferating cell nuclear antigen (PCNA) mRNA in GMCs was examined by reverse transcriptase polymerase chain reaction (RT-PCR). The effects of human recombinant IL-6 (rIL-6) on the proliferation of GMCs and an IL-6 dependent cell line, B9 cells, were evaluated by a colorimetric assay. Results. The IL-6 ELISA study revealed that subconfluent GMCs secreted more IL-6 than confluent GMCs (12.9 ± 2.9 pg/104 cells versus 4.05 ± 0.2 pg/104 cells; P 〈 0.01). In the RT-PCR, the mRNA expression of both IL-6 and PCNA was upregulated in subconfluent GMCs as compared with confluent GMCs. An approximately four-fold increase in IL-6 mRNA expression and a two-fold increase in PCNA mRNA expression were shown. IL-6R mRNA expression was demonstrated in GMCs by RT-PCR. However, recombinant human IL-6, which stimulated the growth of B9 cells in a dose-dependent fashion, did not induce GMC proliferation. Conclusions. GMC-derived IL-6 may have significance as a marker of GMC proliferative activity, although GMC-derived IL-6 per se does not act as an autocrine growth factor for GMCs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012162
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  • 8
    Electronic Resource
    Electronic Resource
    A case of anti-nuclear antibody negative systemic lupus erythematosus associated with penile ulcer (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 405-409 
    Details
    ISSN: 1434-9949
    Keywords: ANA Negative SLE ; Penile Ulcer ; Lupus Nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report here an old male patient with anti-nuclear antibody (ANA) negative systemic lupus erythematosus (SLE) with active renal disease and penile ulcer. He revealed nephrotic syndrome, malar rash and oral ulcer. SLE was discussed, however both ANA and anti-DNA antibody were persistently negative. A penile ulcer was also observed. He died of acute respiratory distress. Autopsy findings including onion skin lesion in the spleen and haematoxylin body in the kidney resulted in the final diagnosis of SLE. To our knowledge, association of penile ulcer with SLE has not yet been reported. Therefore, the present case is thought to be extremely unusual.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231589
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  • 9
    Electronic Resource
    Electronic Resource
    A case of sjögren's syndrome associated with sweet's syndrome (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 101-105 
    Details
    ISSN: 1434-9949
    Keywords: Sjögren's Syndrome ; Sweet's Syndrome ; Nephrocalcinosis ; Renal Failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of Sjögren's syndrome whose clinical course had been indolent until the patient presented with Sweet's syndrome (acute febrile neutrophilic dermatosis). This patient showed renal failure and renal tubular acidosis. Sweet's syndrome resolved within 3 weeks without corticosteroid therapy. Renal biopsy findings were consistent with interstitial nephritis. His renal manifestations responded to corticosteroid therapy and the renal function remained stable during 6 years follow-up without recurrence of Sweet's syndrome. Although close association of both syndromes is already known, in our case Sjögren's syndrome may have been exacerbated by occurrence of Sweet's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238773
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  • 10
    Electronic Resource
    Electronic Resource
    Sintering of yttrias with addition of divalent metal oxide and water vapour pressure dependence of their electrical conductivity (1990)
    Springer
    Journal of materials science 25 (1990), S. 1503-1508 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The sinterability of divalent metal oxide (MO)-doped yttrias and their electrical conductivity have been studied. The density measurement and SEM observation revealed that the addition of a small amount of MO greatly improves the sinterability of yttria. Yttrias with densities more than 97% could be obtained with the addition of CaO, SrO or MgO by sintering in air at 1600
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585473
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