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  • 1
    Electronic Resource
    Electronic Resource
    Mucosal mantle cell (centrocytic) lymphomas (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 26 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The morphology, phenotype, genotype and clinical behaviour of four cases of mantle cell lymphoma (centrocytic lymphoma) presenting primarily in mucosa (two gastric, one in large bowel and one tonsillar) are reviewed. Their relationship with the broader group of mantle cell and mucosa-associated lymphoid tissue (MALT) lymphomas is also discussed. All four tumours showed a monomorphic picture of mantle cells (centrocytes) arranged in a diffuse, or vaguely nodular, pattern. Scattered non-neoplastic germinal centres were entrapped within the tumour cells, although there was no follicular colonization. In two cases distinct epithelial infiltration by tumour cells was observed. All four tumours had a CD19, CD20, CDS, IgD, Leu8 immunophenotype, whereas KiM1P and CD10 expression were absent. DRC antibody showed loose aggregates of dendritic cells in three of four cases. Three cases showed PRAD-1/Cyclin D1 overexpression by Northern blot analysis. Although we were not able to detect bcl-1 rearrangement in the major translocation cluster (MTC) breakpoint, the possibility of bcl-1 rearrangement involving other cluster breakpoints cannot be ruled out. The four cases evolved as a disseminated disease, involving either peripheral lymph nodes, spleen or bone marrow. The biological behaviour of mantle cell lymphoma presenting in mucosa appears, irrespective of localization or macroscopic presentation, similar to that of nodal mantle cell lymphoma. Their tendency to dissemination contrasts with MALT lymphomas, which tend to remain localized, and from which mucosa mantle cell lymphoma must be distinguished. The presence of lymphoepithelial lesions does not seem to be a useful differential feature, since occasional epithelial infiltration was seen in two cases. Reactivity with CD5 appears to be especially useful in distinguishing these, since all four cases were clearly positive, in contrast with what is usually found in MALT lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00248.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cutaneous lymphocyte-associated antigen (CLA) expression in a lymphoblastoid mantle cell lymphoma presenting with skin lesions. Comparison with other clinicopathologic presentations of mantle cell lymphoma (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 28 (2001), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Cutaneous lymphocyte-associated antigen (CLA) is a lymphocyte homing receptor selectively expressed by T cells of the cutaneous immune system and their malignant counterpart, that is to say, cutaneous T-cell lymphomas. However it is absent in the vast mayority of other T-cell malignancies and B-cell lineage lymphomas irrespective on primary tumor site.Methods: Expression of CLA was investigated on six cases of mantle cell lymphoma (MCL) which differed in their histopathological subtype (typical or blastic) and their tendency to infiltrate skin and/or central nervous system (CNS).Results: CLA immunostaining on neoplastic cells was only observed in a 61-year-old female suffering from a lymphoblastoid MCL which clinically presented with specific skin lesions and further developped CNS disease. In this patient, coexpression of CLA with MCL markers (CD20 and CD5) was confirmed by conventional immunohistochemistry and double immunofluorescence studies.Conclusions: To our knowledge, CLA immunoreactivity on B-cell lymphomas has not beeen previously reported. The expression of this skin-related adhesion molecule on malignant MCL cells could explain the clinical behavior of our case which presented and relapsed with cutaneous lesions. However, CLA seems not to be a MCL marker nor a CNS-related adhesion molecule. The authors review the clinical and histopathological characteristics of MCL-specific skin lesions and their diagnostic clues based on cell morphology, immunohistochemistry and molecular investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2001.028005256.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of temperature on epidemiological parameters of Puccinia lagenophorae (2001)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 50 (2001), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The effect of temperature on latent period and aeciospore production of Puccinia lagenophorae on Senecio vulgaris was determined in small-scale experiments under controlled conditions. A clear effect of temperature on latent period was demonstrated. Latent period decreased exponentially with increasing temperature. Both total aeciospore production and net reproductive number increased linearly with increasing temperature in a range from 10 to 22°C. The three parameters were incorporated in models to determine the effect of temperature on epidemic development. The present study suggests an increase in the exponential growth rate, r, and the velocity of focus expansion, V, with temperature. This increase in epidemic development was caused mainly by the effect of temperature on latent period and on net reproductive number. The effect of temperature on the sporulation curve appeared to be less important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3059.2001.00533.x
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  • 4
    Electronic Resource
    Electronic Resource
    Focus expansion of bean rust in cultivar mixtures (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 44 (1995), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Radial expansion of foci in mixtures of susceptible and resistant bean cultivars was studied at two sites in Ethiopia. The foci expanded in a wave-like fashion. At Ambo (1990), radial expansion velocity ranged from 6 cm per day in mixtures with 20% susceptible plants to 15 cm per day in plots with the susceptible plants only. At Debre Zeit, the velocity ranged from 3 cm per day in a mixture with 20% susceptible plants to 16 cm per day in plots with 100% susceptible plants. At both sites the radial expansion velocity of foci correlated linearly with the logarithm of the fraction of susceptible plants in the mixture. Velocities of focus expansion at Ambo and Debre Zeit were approximately equal in plots consisting of susceptible plants only. At lower proportions of susceptible plants the velocities at Debre Zeit were lower than at Ambo. Indications were given as to the environmental factors responsible for the observed difference between sites. At each site, the variation between plots showed a clear spatial pattern, probably due to environmental factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1995.tb01672.x
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in populations of the eyespot fungi Tapesia yallundae and T. acuformis under different fungicide regimes in successive crops of winter wheat, 1984–2000 (2002)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 51 (2002), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Effects of regular treatments with the fungicides carbendazim and prochloraz applied to whole plots divided into subplots with different initial population mixtures of carbendazim-sensitive or carbendazim-resistant Tapesia yallundae or T. acuformis were studied in successive crops of winter wheat from 1984/85 to 1999/2000. In unsprayed and carbendazim-sprayed whole plots, a stable coexistence of about 50% each of T. yallundae and T. acuformis developed within five seasons, but in whole plots sprayed with prochloraz or prochloraz plus carbendazim, the proportion of T. acuformis increased to 〉 80%. A discrete time difference equation model was derived from knowledge of the biology of eyespot and competition theory to describe the population changes. The model was fitted to the data from treatments where coexistence occurred [subplots in unsprayed (1985–92) and carbendazim-sprayed (1985–89) whole plots], using nonlinear least squares regression. The optimized value of the resource overlap coefficient was small, suggesting niche differences between the two species. Populations were nearly 100% carbendazim-resistant in carbendazim-sprayed whole plots by July 1985 (one season) and in whole plots sprayed with prochloraz plus carbendazim by July 1986 (two seasons). In prochloraz-sprayed whole plots, the proportion of carbendazim-resistant isolates decreased more rapidly than in unsprayed whole plots in the 1980s, but by July 1992 a shift in populations in unsprayed and prochloraz-sprayed whole plots towards predominantly carbendazim-resistant strains had occurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3059.2002.00673.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of temperature on latent period of septoria leaf blotch on winter wheat under outdoor conditions (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 53 (2004), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Batches of two winter wheat cultivars (Riband and Apollo) were inoculated with conidia of Mycosphaerella graminicola at weekly intervals over a 2 year period. Following 72 h incubation, plants were placed in ambient temperatures ranging between −7 and 32°C with mean batch temperatures of 2·9–20·2°C. Latent period until the first visible symptoms ranged between 11 and 42 days. The relationship between development of lesions and accumulated thermal time was described using a shifted cumulative gamma distribution model. The model provided good estimates of lesion development with r2 〉 0·92 for both cultivars. Base temperatures, below which the pathogen did not develop, were estimated from the model as approximately −2·4°C for the two cultivars. Latent period was estimated as being 250 and 301 degree-days above the estimated base temperature, when defined as time from inoculation to first lesion and time to 50% of maximal lesions, respectively, for cv. Riband. The values for cv. Apollo were similar, but with estimates of thermal time periods c. 5% higher. The relationship between mean temperature and inverse latent period, expressed as days either to first lesion or to 50% of maximal lesions, was best described by a linear regression with r2 〉 0·96 for both cultivars. The opportunity for plants to outgrow disease was reduced when prolonged periods of cold temperature occurred, because the base temperature for growth of the pathogen was less than that for the crop.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0032-0862.2004.00983.x
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  • 7
    Electronic Resource
    Electronic Resource
    Hematopoietic stem cell transplantation in chronic lymphocytic leukemia: A report of 12 patients from a single institution (1998)
    Springer
    Annals of oncology 9 (1998), S. 167-172 
    Details
    ISSN: 1569-8041
    Keywords: chronic lymphocytic leukemia ; hematopoietic stem cell transplantation ; minimal residual disease ; molecular remissions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Stem-cell transplantation is a reasonable therapeutic approach for younger patients with high-risk CLL. Patients and methods: Twelve patients (seven males; median age 47 years, range 29–51) with high-risk CLL underwent transplantation (allo, n = 7; auto, n = 5). The conditioning regimen consisted of cyclophosphamide and total body irradiation in 11 patients, and BEAC in the remaining one. Minimal residual disease (MRD) was assessed by cytofluorometry and PCR. Results: All 11 evaluable patients engrafted. Of the seven allografted patients, two died of treatment-related causes; three patients developed acute GVHD. No transplant-related mortality was observed in autografted patients. After transplantation, 10 of 11 patients evaluable for response achieved CR (91%; 95% CI 59%–100%) which was molecular in nine patients (82%; 95% CI 48%–98%). One patient in CR but MRD+ relapsed nine months after transplantation and died. Seven patients remain in molecular CR for a median of 16 months (range 1–58). Estimated actuarial survival and disease-free survival at two years is 81% (95% CI 43%–100%) and 71% (95% CI 43%–99%), respectively. Relapse risk at two years is 12.5% (95% CI 0%–35.5%). Conclusions: Patients with high-risk CLL can achieve long-lasting molecular CR after SCT. The role of transplants in CLL management deserves investigation in controlled trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008266505896
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  • 8
    Electronic Resource
    Electronic Resource
    The quasimolecular 1sσ orbital in collision systemsα(Z 1+Z 2)≳1, its excitation and spectroscopy (1980)
    Springer
    The European physical journal 296 (1980), S. 11-21 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An analytical formula for the excitation probability of the quasimolecular 1sσ orbital as a function of the impact parameterb is derived for collision systems withα(Z 1+Z 2)≳1. This formula describes well all existing experimental data for those collision systems except for the heaviest system Pb+Cm (Z 1+Z 2=178) at impact parametersb≲40 fm. It is discussed in which way energies of the quasimolecular 1sσ orbital can be extracted from experimental 1sσ vacancy production data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415610
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  • 9
    Electronic Resource
    Electronic Resource
    Peripheral T-cell lymphomas: Initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification (1998)
    Springer
    Annals of oncology 9 (1998), S. 849-855 
    Details
    ISSN: 1569-8041
    Keywords: peripheral T-cell lymphomas ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Peripheral T-cell lymphomas (PTCL) account for about 10% of all lymphomas in Western countries. The aim of the present study is to analyze the initial characteristics and prognostic factors in a large series of PTCL patients. Patients and methods: 174 patients (105 male/69 female; median age 61 years) were diagnosed with PTCL according to the R.E.A.L. Classification in nine Spanish institutions between 1985 and 1996. Cutaneous lymphomas and T-cell chronic lymphocytic/prolymphocytic leukemia were excluded from the study. Univariate and multivariate analyses were used to assess the prognostic value of the main initial variables. Results: The distribution according to histology subgroup was: PTCL unspecified, 95 cases (54.4%); anaplastic large-cell Ki-1-positive (ALCL), 30 cases (17%); angioimmunoblastic T cell, 22 cases (13%); angiocentric, 14 cases (8%); intestinal T cell, 12 cases (7%), and hepatosplenic γδ T cell, one case (0.6%). As compared to the other types, ALCL presented more frequently in ambulatory performance status, without extranodal involvement, in early stage, normal serum β2-microglobulin (B2M) level and low-risk international prognostic index (IPI). Most patients were treated with adriamycin-containing regimens. The overall CR rate was 49% (69% for ALCL vs. 45% for other PTCL; P 〈 0.02). The risk of relapse was 48% at four years. Median survival of the series was 22 months (65 months for ALCL vs. 20 months for other PTCL; P = 0.03), with a four-year probability of survival of 38% (95% confidence intervals (95% CI): 28–48). In the univariate analysis, in addition to the histology, older age, poor performance status, presence of B-symptoms, extranodal involvement, bone marrow infiltration, advanced Ann Arbor stage, high serum LDH, high serum B2M, and intermediate- or high-risk IPI were related to poor survival. In the multivariate analysis the histologic subgroup (ALCL vs. other PTCL) (P = 0.02; response rate (RR): 4.3), the presence of B-symptoms (P = 0.02, RR: 2.2), and the IPI (low vs. high) (P = 0.04, RR: 2) maintained independent predictive value. When the analysis was restricted to the unspecified subtype, only IPI had independent prognostic value (P = 0.003; RR: 3.5). Conclusions: PTCL have adverse prognostic features at diagnosis, respond poorly to therapy and have short survival, with no sustained remission. ALCL constitutes a subgroup which responds better to therapy and has a longer survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008418727472
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  • 10
    Electronic Resource
    Electronic Resource
    Expression von Zellzykluskomponenten in fortgeschrittenen Kopf-Hals-Karzinomen Bedeutung für die Prognose nach primärer akzelerierter Radiochemotherapie (1999)
    Springer
    HNO 47 (1999), S. 777-786 
    Details
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Kopf-Hals-Tumoren ; Prognostische Faktoren ; Radiochemotherapie ; Zellzyklusproteine ; Key words Head and neck tumors ; Radiochemotherapy ; Prognostic factors ; Cell-cycle regulatory proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Primary radiochemotherapy is gaining increasing importance for the treatment of advanced head and neck squamous cell carcinomas. However, there is a lack of clinical factors concerning prognostic information in relation to treatment. In this pilot study, we examined whether molecular factors can provide such information. Patients and methods: The expression patterns and their possible prognostic relevance of the cell cycle regulatory proteins p53, p21WAF/CIP1, Rb, p16INK4A, CDK4 and Cyclin D1, MIB1 (Ki-67) and BCL-2 were analysed in pretreatment tumor biopsies from 43 patients with advanced carcinomas of the oropharynx (n=26), hypopharynx (n=10) and larynx (n=7) by applying immunohistochemistry to paraffin sections of tumor specimens. All patients were treated by the same method of an accelerated ”concomitant boost” radiochemotherapy with carboplatin in a phase II study. Median followup time was 56 months. Results: No correlation was found between any of the markers and the remission rate, T-stage, N-stage, rate of loco-regional recurrences and distant metastases. However, independent of the tumor stage, patients with CDK4/cyclin-D1 overexpressing tumors had a significantly shortened overall survival (P=0.014 and 0.026, respectively). Conclusion: The results of this pilot study indicate that CDK4 and cyclin D1 over-expression provide useful prognostic information about clinical outcome after primary radiochemotherapy of head and neck cancer patients.
    Notes: Zusammenfassung Hintergrund: Bei fortgeschrittenen Kopf-Hals-Karzinomen wird in zunehmendem Maße die primäre Radiochemotherapie einer primär operativen Therapie vorgezogen. Klinische prognostische Faktoren für die Krankheitsverläufe nach primärer Radiochemotherapie fehlen jedoch. Die vorliegende Pilotstudie sollte klären, ob molekulare Faktoren prognostische Aussagen liefern können. Patienten und Methoden: In prätherapeutischen Biopsien von 43 Patienten mit fortgeschrittenen Karzinomen wurde die Expression der Zellzykluskomponenten p53, p21WAF/CIP1, Rb, p16INK4A, CDK4 und Cyclin D1, des Proliferationsmarkers MIB1 und des apoptosehemmenden Proteins BCL-2 immunhistochemisch bestimmt. Die Patienten wurden nach dem Protokoll einer akzelerierten „Concomitant-boost-Radiochemotherapie” mit Carboplatin im Rahmen einer Phase-II-Studie behandelt. Die mediane Beobachtungszeit zum Analysezeitpunkt betrug 56 Monate. Ergebnisse: Keiner der Marker korrelierte mit dem Tumorstadium und N-Status, den Remissionsraten nach Therapieende oder dem posttherapeutischen Auftreten von Rezidiven, Metastasen und Zweitkarzinomen. Dahingegen hatten Patienten mit CDK4- und Cyclin D1-überexprimierenden Tumoren unabhängig vom Tumorstadium eine signifikant kürzere Gesamtüberlebenszeit (p=0,014 bzw. 0,026). Schlußfolgerung: Die Ergebnisse der Pilotstudie indizieren eine prognostische Bedeutung der Überexpression von CDK4 und Cyclin D1 nach primärer Radiochemotherapie von fortgeschrittenen Kopf-Hals-Karzinomen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001060050460
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