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  • 2000-2004  (8)
  • 1990-1994  (7)
  • 1985-1989  (12)
  • 1980-1984  (4)
  • 11
    Electronic Resource
    Electronic Resource
    The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To investigate the EP receptor subtype involved in the gastroprotective action of prostaglandin (PG) E2 using various EP receptor agonists in rats, and using knockout mice lacking EP1 or EP3 receptors. Methods: Male SD rats and C57BL/6 mice were used after an 18-h fast. Gastric lesions were induced by oral administration of HCl/ethanol (150 m m HCl in 60% ethanol). Rats were given various EP agonists i.v. 10 min before HCl/ethanol: PGE2, sulprostone (EP1/EP3 agonist), butaprost (EP2 agonist), 17-phenyl-ω-trinorPGE2 (17-phenylPGE2: EP1 agonist), ONO-NT012 (EP3 agonist) and 11-deoxyPGE1 (EP3/EP4 agonist). In a separate study, the effect of PGE2 on HCl/ethanol lesions was examined in EP1- and EP3-receptor knockout mice. Results: Gastric lesions induced by HCl/ethanol were dose dependently prevented by PGE2; this effect was mimicked by sulprostone and 17-phenylPGE2 and was significantly antagonized by ONO-AE-829, an EP1 antagonist. Neither butaprost, ONO-NT012 nor 11-deoxyPGE1 exhibited any protective activity against HCl/ethanol-induced gastric lesions. PGE2 caused an inhibition of gastric motility as well as an increase of mucosal blood flow and mucus secretion, the effects being mimicked by prostanoids activating EP1 receptors, EP2/EP3/EP4 receptors and EP4 receptors, respectively. On the other hand, although HCl/ethanol caused similar damage in both wild-type mice and knockout mice lacking EP1 or EP3 receptors, the cytoprotective action of PGE2 observed in wild-type and EP3-receptor knockout mice totally disappeared in mice lacking EP1 receptors. Conclusion: The gastric cytoprotective action of PGE2 is mediated by activation of EP1 receptors. This effect may be functionally associated with inhibition of gastric motility but not with increased mucosal blood flow or mucus secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1116.x
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  • 12
    Electronic Resource
    Electronic Resource
    Reflection electron microscopy (1987)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 20 (1987), S. 147-160 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Reflection electron microscopy (REM) in ultra-high vacuum (UHV) conditions is reviewed. UHV-REM can characterize surface structures of monolayer levels such as steps, domains of reconstructed surface structures and their boundaries and these capabilities are used to observe surface dynamic processes such as phase transitions of reconstructed surface structures and adsorbate structures and adsorption processes, oxidations, sublimations and ion-sputtering and annealing. The method is compared with other surface-imaging techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889887086916
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  • 13
    Electronic Resource
    Electronic Resource
    Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 420 (2002), S. 563-573 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones. Here we report the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01266
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  • 14
    Electronic Resource
    Electronic Resource
    Electron microscope analyses of domains and discommensurations in ferroelectric Rb2ZnCl4. Erratum (1989)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 45 (1989), S. 146-146 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The following corrections should be made in Tsuda, Yamamoto & Yagi [Acta Cryst. (1988). A44, 864-870]. (1) 'only two kinds of domain boundaries' in the Abstract should be changed to 'two kinds of image contrast of domain boundaries'. (2) The expressions for h2, h4, h6 in § 4.1 should be replaced by h2: -x -y -z + h4: -x -y -z (inversion) h6: -x -y -z + (3) "two kinds of DC's showing different contrast' in the second paragraph in § 4.1 should be changed to 'two kinds of DC contrast'.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767388012395
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  • 15
    Electronic Resource
    Electronic Resource
    Electron microscope analyses of domains and discommensurations in ferroelectric Rb2ZnCl4 (1988)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 44 (1988), S. 864-870 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Image contrast of domains and discommensurations in ferroelectric Rb2ZnCl4 is studied. Six domains of the two orientation variants and three translation variants in the ferroelectric phase are observed. However, only two kinds of domain boundaries, which are the discommensurations in the incommensurate phase of Rb2ZnCl4, are observed. These observations agree with group-theoretical considerations of the phase transition from the normal phase to the commensurate phase of Rb2ZnCl4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767388004945
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  • 16
    Electronic Resource
    Electronic Resource
    Lipid peroxidation caused by chinoform-ferric chelate in cultured neural retinal cells (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1561-1563 
    Details
    ISSN: 1420-9071
    Keywords: Lipid peroxidation ; chinoform-ferric chelate ; chick neural retinal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Incorporation of chinoform-ferric chelate was demonstrable in cultured neural retinal cells of chick embryos after 1 h of incubation, and the lipid peroxide level in the cells was increased strikingly 1 h thereafter. On the other hand, free ferric ions were scarcely incorporated into the cells, and a significant increase in the lipid peroxide level in the cells was not observed. These data indicate that chinoform is carrier of iron for its passage through cell membranes and that the incorporated iron induces lipid peroxidation which in turn leads to neural cell degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964807
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  • 17
    Electronic Resource
    Electronic Resource
    Phosphoramidon enhances allatostatin-mediated inhibition of juvenile hormone biosynthesis in the corpora allta of the cockroach,Diploptera punctata (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 758-761 
    Details
    ISSN: 1420-9071
    Keywords: Corpora allata ; juvenile hormone biosynthesis ; allatostatins ; phosphoramidon ; enkephalinase ; cockroach ; Diploptera punctata ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Use of the enkephalinase inhibitor phosphoramidon in the in vitro radiochemical assay for juvenile hormone biosynthesis enhanced allatostatin-mediated inhibition of hormone production by corpora allata of the cockroach,Diploptera punctata. Significant increases in inhibition in day 2 virgin female CA by AST 1 (at 10−7 M) and AST 4 (10−8–10−7 M) were observed in the presence of phosphoramidon (10−5M or greater). No significant increases in inhibition were seen in CA from day 6 mated females with AST 4 (10−9–10−7M) and phosphoramidon combined. Phosphoramidon alone had no effect on JH biosynthesis. Analysis of allatostatin content of the CA, as determined by ELISA, revealed that addition of phosphoramidon to the medium increased the endogenous allatostatin conten in CA of virgin and mated females. The similarity in primary structure between allatostatins and enkephalin-like peptides and their similar distribution makes it probable that phosphoramidon acts by preventing breakdown of allatostatins within the CA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124297
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  • 18
    Electronic Resource
    Electronic Resource
    Petrology and magnetic properties of the Chiang Khan, Thailand, meteorite (1989)
    Springer
    Mineralogy and petrology 40 (1989), S. 173-182 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Summary The Chiang Khan meteorite fell on 18th November, 1981 at Chiang Khan, Thailand. It consists of olivine, orthopyroxene, clinopyroxene, Fe-Ni metal, troilite, chromite, plagioclase, glass, and phosphate in order of abundance. Olivine forms barred or porphyritic chondrules, and its composition is uniform (average Fo80.2), close to the average composition of olivine in equilibrated H chondrites. Orthopyroxene and clinopyroxene also have compositions similar to those in equilibrated H chondrites. Both well-defined chondrules and their broken fragments are present in the recrystallized matrix. Microcrystalline plagioclase and clinopyroxene often occur in the groundmass of chondrules, but clear interstitial plagioclase is absent. Chemical composition of chromite plots in the field of chromites in H chondrites. Chiang Khan meteorite is thus classified as an equilibrated H 5 type chondrite. The equilibrium temperatures estimated by using mineral pairs are as follows: Opx-Cpx 800–900°C; Ol-Chromite 510°C. Water content is 0.24 wt %, and the hydrogen isotopic composition (ΔD) is −89.5‰ In the thermal demagnetization experiment magnetization steadily decreased from 0 to 500°C, whereas the remanent magnetization obtained in the A.C. demagnetization experiment is very unstable, probably owing to the large grain size of the Fe-Ni metal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01164487
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  • 19
    Electronic Resource
    Electronic Resource
    Stimulation-dependent changes in synaptic effects on unit activity of medial preoptic nucleus neurones in rats (1980)
    Springer
    Experimental brain research 39 (1980), S. 121-124 
    Details
    ISSN: 1432-1106
    Keywords: Amygdala ; Medial preoptic nucleus ; Median eminence ; Rat ; Synaptic plasticity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stimulation-dependent changes in synaptic effects were observed in medial preoptic nucleus neurones during stimulation of the amygdala or pyriform cortex in anaesthetized female rats. The changes occurred after 35–240 triple pulse stimuli repeated at 0.89 Hz. Median eminence stimulation did not produce any synaptic change. These data show the existence of synaptic plasticity in the neural pathway from the amygdala and pyriform cortex to the medial preoptic nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237076
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  • 20
    Electronic Resource
    Electronic Resource
    Expression of the mutant gene for L-gulono-γ-lactone oxidase in scurvy-prone rats (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 126-129 
    Details
    ISSN: 1420-9071
    Keywords: L-gulono-γ-lactone oxidase ; ascorbic acid deficiency ; enzyme defect ; rat ; nuclei acid hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A mutant strain of Wistar rats with L-gulono-γ-lactone oxidase deficiency has recently been established. To investigate this deficiency by DNA and RNA blot hybridization analyses, a fragment of a previously cloned cDNA encoding rat L-gulono-γ-lactone oxidase was used as a probe. When genomic DNA of the mutant rat was digested with several restriction enzymes, the probe hybridized to fragments of the same sizes as those produced from DNA of normal rats. Poly(A)+RNA from the liver of the mutant rat was found to contain an L-gulono-γ-lactone oxidase-specific mRNA of a normal size at a comparable level to that of normal rats. An in vitro translation experiment revealed that the mRNA programmed the synthesis of an enzyme protein which had the same molecular weight as that of the translational product of the normal mRNA, although the amount synthesized was markedly reduced as compared with that synthesized with the normal mRNA. In accordance with this observation, a very low but definite degree of L-gulono-γ-lactone oxidase activity was detected in the microsomes of the mutant rat by a newly developed, highly sensitive method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954844
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