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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of Type II Collagen Reactive T Cells in the Mouse (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The specificity of the recognition of type II collagen (CII) by T cells in the DBA/1 mouse was analysed using fragments of chick and rat CII obtained by cyanogen bromide (CB) cleavage. Firstly DBA/1 mice were immunized with chick CB fragments 5, 8, 9, 10, 11 and 12. Ten days later the draining lymph node cells were cultured with rat and mouse CII and the proliferative response was determined by incorporation of [3H]thymidine All peptides were capable of triggering T cells recognizing rat CII but only CB9 immunized mice responded well to mouse CII. Secondly, lymph node cells from CBA/1 mice immunized with rat and mouse CII were cultured with the CB fragments including rat CB10 and CB11, and the proliferative response was determined. After immunization with rat CH, the response was strongly dominated by T cells recognizing CB11 with equal responses against chick and rat CB11. After immunization with mouse CH only rat CB10 gave a strong response. It is concluded that several epitopes on the CH molecule can be recognized by T cells in the DBA/1 mouse and that most of these epitopes are shared by rat and chick CH but not mouse CH. These epitopes exhibit strong immunodominance. In mice immunized with intact heterologous CH, the immunodominant response is directed against one or more epitopes on the CB11 fragment present on several heterologous CH but apparently not on mouse CH. In mice immunized with autologous CH the immunodominant response is directed against one or more epitopes on the CBl0 fragment present on rat and mouse CH. They are either absent in chick CH or located in the carboxyterminal end of the CB10 fragment where a cyanogen bromide cleavage site is present in chick CH but not in rat CH. These results suggest that the proposed importance of CBH in collagen-induced arthritis is due to activation of T cells reactive with heterologous CH only. These cells may be important for the induction of the strong auto-antibody-response after immunization with heterologous CH. Structures of importance for direct T cell involvement in the arthritic process and recognized by autoreactive T cells are suggested to be found on CB10.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb02520.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tests of the Electroweak Theory at the Zresonance (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nuclear and Particle Science 41 (1991), S. 55-96 
    Details
    ISSN: 0163-8998
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ns.41.120191.000415
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  • 3
    Electronic Resource
    Electronic Resource
    Crude and age-specific incidence of cancer of the stomach, colon, breast, and lung ascertained by autopsy frequency in the Heidelberg area from 1900 to 1975 (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 11-25 
    Details
    ISSN: 1432-1335
    Keywords: Incidence-Autopsy Frequency-Cancer of the Stomach, Colon, Breast, and Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Time independence of the selection of autopsy material of the Institute of Pathology of the University of Heidelberg can be assumed as all factors depending on this selection show a remarkable steadiness during the period covered: The mean age of death of patients on whom an autopsy was performed and was not performed is the same, the sex ratio remains unchanged, the number of persons who died in the Heidelberg area has decreased only slightly, and the percentage of dead patients with last residence in this area that were autopsied also remains unchanged. By documenting all pathoanatomic disease without separating the cause of death, the crude and age-specific incidence of lung, colon, breast, and gastric cancer can be estimated from the beginning of this century up to the present time. The data given in this paper show a decrease of the risk of gastric cancer at younger ages, a quite steady risk of colon cancer, and a steeply increasing risk of lung and breast cancer. The epidemiologic meaning of these data is discussed briefly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412893
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  • 4
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    Auf dem Kurs des X. Parteitages (1982)
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 30:1 (1982) 41 
    Details
    ISSN: 0012-1045
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1982-030-01-000004
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  • 5
    Electronic Resource
    Electronic Resource
    Prospektive multizentrische Beobachtungsstudie zur frühen rheumatoiden Arthritis – Prognostische Faktoren und Verlaufsprädiktoren (2000)
    Springer
    Zeitschrift für Rheumatologie 59 (2000), S. 113-116 
    Details
    ISSN: 0340-1855
    Keywords: Schlüsselwörter Rheumatoide¶Arthritis – Frühstadien –¶multizentrische Studie –¶prognostische Faktoren ; Key words Rheumatoid arthritis – early arthritis – multicenter trial – prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The aim of a new prospective, multicenter trial on early rheumatoid arthritis is to evaluate parameters of potential relevance for the prediction of an erosive disease course. The integration of general practitoners, rheumatologists, arthritis care units and experimental research groups in a network structure is intended to improve the cooperation between basic and clinical research as well as the treatment of the patients. The final goal is to identify new parameters that may improve an early stratification of patients into the appropriate treatment areas.
    Notes: Zusammenfassung In Deutschland ist eine prospektive multizentrische Studie zur frühen rheumatoiden Arthritis geplant. Die Einbindung von Hausärzten, klinisch-tätigen und niedergelassenen Rheumatologen, aber auch von kompetenten Grundlagen-orientiert arbeitenden Forschergruppen in einer Netzwerkstruktur soll sowohl die Zusammenarbeit zwischen experimenteller und klinischer Forschung verbessern als auch der Versorgung der Rheumapatienten zugute kommen. Ziel der Studie ist die Evaluation potentieller Verlaufsprädiktoren, die in der Zukunft eine frühe Patientenstratifikation in risikoadaptierte Therapiearme verbessern sollen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003930050214
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  • 6
    Electronic Resource
    Electronic Resource
    Über Differentialgleichungen (1901)
    Springer
    Monatshefte für Mathematik 12 (1901), S. 290-298 
    Details
    ISSN: 1436-5081
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01692131
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  • 7
    Electronic Resource
    Electronic Resource
    A measurement of differential cross-sections and nucleon structure functions in charged-current neutrino interactions on iron (1991)
    Springer
    The European physical journal 49 (1991), S. 187-223 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A high-statistics measurement of the differential cross-sections for neutrino-iron scattering in the wide-band neutrino beam at the CERN SPS is presented. Nucleon structure functions are extracted and theirQ 2 evolution is compared with the predictions of quantum chromodynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01555493
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  • 8
    Electronic Resource
    Electronic Resource
    Higgs physics with a $\gamma \gamma$ collider based on CLIC 1 (2003)
    Springer
    The European physical journal 28 (2003), S. 27-44 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We present the machine parameters and physics capabilities of the CLIC Higgs Experiment (CLICHE), a low-energy $\gamma \gamma$ collider based on CLIC 1, the demonstration project for the higher-energy two-beam accelerator CLIC. CLICHE is conceived as a factory capable of producing around 20,000 light Higgs bosons per year. We discuss the requirements for the CLIC 1 beams and a laser backscattering system capable of producing a $\gamma \gamma$ total (peak) luminosity of $2.0 (0.36) \times 10^{34}$ cm-2s-1 with $E_{CM}(\gamma \gamma) \sim 115$ GeV. We show how CLICHE could be used to measure accurately the mass, $\bar b b$ , WW and $\gamma \gamma$ decays of a light Higgs boson. We illustrate how these measurements may distinguish between the Standard Model Higgs boson and those in supersymmetric and more general two-Higgs-doublet models, complement ing the measurements to be made with other accelerators. We also comment on other prospects in $\gamma \gamma$ and $e^- \gamma$ physics with CLICHE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjc/s2002-01113-3
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  • 9
    Electronic Resource
    Electronic Resource
    Population based pathology statistics of oesophageal carcinoma (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 292-298 
    Details
    ISSN: 1432-1335
    Keywords: Oesophageal cancer ; Epidemiology ; Pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The frequency of oesophageal carcinoma among autopsies performed in the Institute of Pathology in Heidelberg between 1900 and 1979 is estimated and compared with the findings of the patho-anatomically based Regional Cancer Registry of North Baden. The autopsy data suggest that there is no increase in the percentage of oesophageal carcinoma in the area of Heidelberg during the period considered. The average age of oesophageal carcinoma patients at death remained nearly unchanged during the study period, while the average age of death for all autopsies showed a steep increase. In a retrospective study of the registry data, oesophageal carcinoma patients showed a higher percentage of alcohol consumers and heavy smokers over patients with stomach, colon, and rectal cancer. The retrospective study of clinical findings further revealed liver cirrhosis in 8%. This was not documented in patients with other gastro-intestinal carcinomas. The results obtained suggest that patho-anatomical data may be useful for checking the applicability of results obtained elsewhere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395761
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  • 10
    Electronic Resource
    Electronic Resource
    An improved measurement of electroweak couplings frome + e −→e + e − ande + e −→μ + μ − (1984)
    Springer
    The European physical journal 22 (1984), S. 13-21 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present an analysis of electroweak leptonic couplings from high statistics experiments on Bhabha scattering and μ pair production at an energy of 34.5 GeV. The forward-backward charge asymmetry of the μ pairs was measured to be −0.098±0.023±0.005. The data were found to agree well with the standard theory of electroweak interaction giving sin2θ W =0.27±0.07. The leptonic weak couplings were determined to beg v=0.000±0.170 andg A=−0.481±0.055. The data were also used to investigate a class of composite models for leptons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01577559
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