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  • 2000-2004  (2)
  • 1985-1989  (1)
  • 1980-1984
  • tracking  (2)
  • 6-mercaptopurine  (1)
  • 1
    ISSN: 1573-904X
    Keywords: pharmacokinetics ; 6-mercaptopurine ; targeted drug delivery ; renal transplantation ; intraarterial infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We developed a canine renal allograft model utilizing implantable infusion pumps and biocompatible catheters to investigate the pharmacokinetics of local immunosuppressive drug administration. Seven mongrel dogs underwent bilateral nephrectomy and autotransplantation of one kidney to the iliac vessels. The proximal end of an infusion catheter directed into the iliac artery was tunneled to a subcutaneously placed programmable pump. A second, sampling catheter was placed with its tip in the iliac vein. Simultaneous regional (iliac vein) and systemic (jugular vein) venous concentrations of 6-mercaptopurine (6-MP), the immunosuppressive metabolite of azathioprine, were determined during a continuous 24-h intraarterial infusion (10 mg/kg/24 hr). The gradient between regional and systemic 6-MP concentrations was maximal initially when the pump was turned on, continuously decreased until steady state was reached, and disappeared immediately after the pump was turned off. The mean ratio of steady-state iliac vein to systemic 6-MP concentrations was 5.0 ± 1.4, demonstrating a pharmacokinetic advantage of continuous intraarterial 6-MP infusion to the autotransplanted kidney. The novel canine renal allograft model described herein overcomes the technical limitations of earlier models and represents a foundational step in the design of intrarenal infusion patterns of immunosuppressive agents which we expect to prolong survival of the allotransplanted kidney with minimal systemic drug exposure and side effects.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5133
    Keywords: movement behavior ; tracking ; elasmobranch ; ultrasonic telemetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We used ultrasonic telemetry to determine the movement directions and movement rates of leopard sharks, Triakis semifasciata, in Tomales Bay, California. To analyze tide and time of day effects, we surgically implanted transmitters in the peritoneal cavities of one male and five female leopard sharks, which we located during summer for three to five sampling sessions lasting 12 to 24 h each. All leopard sharks showed strong movement direction patterns with tide. During incoming tides, sharks moved significantly (p〈0.0001) towards the inner bay, apparently to exploit the extensive inner bay muddy littoral zones' food resources. On outgoing tides, sharks showed significant (p〈0.0001) movements towards the outer bay. During high tide, there was no discernible pattern to their movements (p=0.092). Shark movement rates were significantly (p〈0.0001) greater during dark periods (mean±SE: 10.5±1.0 m min−1), compared with fully lighted ones (6.7±0.5 m min−1). Movement rates of longer sharks tended to be greater than those of shorter ones (range means±SE: 5.8±0.6 m min−1 for the 91 cm shark, to 12.8±1.6 m min−1 for the 119 cm shark), but the leopard sharks' overall mean movement rate (8.1±0.5 m min−1) was slower than other (more pelagic) sharks.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5133
    Keywords: elasmobranch ; movement behavior ; Myliobatidae ; tracking ; ultrasonic telemetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We used ultrasonic telemetry to examine movement patterns of 11 bat rays, Myliobatis californica, in Tomales Bay, California. Tomales Bay is long (20 km) and narrow (1.4 km), and is hydrographically separated into outer and inner bay regions. The outer bay (the outermost 8 km) is characterized by oceanic conditions while the shallow inner bay (the innermost 12 km) features wide seasonal temperature shifts. Five rays were tracked monthly from October 1990 to November 1991 and six rays (four of which carried temperature-sensing transmitters) were tracked daily from 30 June to 16 July 1992. Mean bat ray movement rate was 8.84 m min−1 (range 4.49 to 13.40 m min−1) and was not significantly affected by size (p=0.592), tidal stage (p=0.610), or time of day (p=0.327). Movement direction was unrelated to tidal stage (p=0.472) but showed a highly significant diel pattern (p〈0.001). From 2:50–14:50 h, rays moved toward the warmer and shallower inner bay, while from 14:50–2:50 h they moved toward the cooler and deeper outer bay. These telemetry data, along with known bat ray foraging patterns and respiratory temperature-sensitivity, argue for behavioral thermoregulation as the primary influence on this movement pattern.
    Type of Medium: Electronic Resource
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