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  • 2000-2004  (2)
  • 1985-1989  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 21 (2000), S. 587-611 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Estimating preferences for states of health has been an active area of research in recent years. Unlike psychophysical approaches, which discriminate levels of health status, preference-based approaches incorporate values or utilities for health outcomes and can be used in cost-effectiveness analyses to aid resource allocation decisions. This chapter considers issues and controversies involved in using preference-based measures in economic evaluation in health care, with a particular emphasis on cost-utility analysis and the estimation of quality-adjusted life years. Topics considered include techniques for measuring preferences, the use of preference-based classification systems, the relationship between patient and community preferences, methods for obtaining utilities from clinical trials, mapping health status from health utilities, the development of "off-the-shelf" preference weights, and proposed alternatives to quality-adjusted life years. We also consider applications of cost-utility analyses to public health interventions. Although cost-utility analyses have become more popular recently, many challenges remain for the field. Widespread acceptance of the methodology likely awaits more consensus on measurement techniques, as well as educational efforts in the public health and medical communities on the usefulness of the approach.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 67 (1986), S. 0 
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Removal of the shoot above the primary node (detopping) of 3-week-old bean plants (Phaseolus vulgaris L. cv. Contender) altered the metabolism and development of the remaining leaves. An increase in levels of chlorophyll, protein, stomatal opening, photosynthesis and growth, i.e. rejuvenation of primary leaves, was established within 7 days of detopping. These levels were maintained while the primary leaves of equivalent intact plants senesced.The flux of xylem solution (mineral ions, cytokinins and water) into leaves is related to the leaf area to be supplied and root supply capacity; it has been suggested that detopping leads to an increased availability of root-supplied solutes and hence rejuvenation of the remaining leaves. This assumes however that root output of solutes is not decreased by the defoliation treatment.We found that root output of ions (electrical conductivity of passive xylem exudate) in detopped plants was 30% lower than in intact plants after 24 h and 60% lower after 7 days. The output of Ca2+, Mg2+ and K+ were similarly reduced 7 and 14 days after detopping as were fresh and dry weights of roots. Furthermore, neither the calculated xylem flux of ions nor directly measured levels of Ca2+, Mg2+ and K+ were significantly increased in leaves of detopped plants during their rejuvenation. We therefore conclude that root output is tightly coupled to shoot demand and that the apparent rejuvenation of primary leaves caused by detopping bean plants is not a consequence of increased xylem flux of mineral ions into the leaves.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillan Magazines Ltd.
    Nature 406 (2000), S. 474-475 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Home-site fidelity is well known in migratory animals, but not in social insects. Here we show that colonies of the giant honeybee Apis dorsata are able to find the same nest location even after seasonal migration. As worker bees do not have first-hand knowledge of the old nest site, the ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archive for mathematical logic 27 (1988), S. 189-192 
    ISSN: 1432-0665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 11 (1985), S. 194-197 
    ISSN: 1619-7089
    Keywords: Thyroid scintigraphy ; Computer-assisted scintigraphy ; Rectilinear scanning ; Image modulation ; Count density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared rectilinear scanning, analogous gamma-camera imaging and imaging using a gamma camera interfaced to a computer in order to determine which of these techniques is superior for thyroid scintigraphy. Forty patients with and without goitre and irregular activity distribution were imaged using each of the three techniques. The sets of three scintigrams per patient were rated by seven physicians. These ratings were statistically analysed using a new distribution-free test. Thyroid scintigraphy using a gamma camera interfaced to a computer turned out to be the best method, especially for detecting circumscribed areas of increased uptake. We conclude that this was due to a combination of the following factors: a computer matrix of 128x128 pixels in combination with an acquisition zoom of 1.5, the high count density of the scintigrams, computer-controlled documentation after data acquisition and the use of a continuous grey scale for documentation. The improved quality and information content of the scintigrams obtained using a gamma-camera/computer system could improve the diagnostic value of thyroid scintigraphy, especially when the scintigrams are also evaluated quantitatively.
    Type of Medium: Electronic Resource
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