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  • 1
    Electronic Resource
    Electronic Resource
    Non-Hodgkin's lymphoma in pediatric patients with chromosomal breakage syndromes (AT and NBS): Experience from the BFM trials (2000)
    Springer
    Annals of oncology 11 (2000), S. 141-145 
    Details
    ISSN: 1569-8041
    Keywords: AT ; ataxia teleangiectasia ; Nijmegen-Breakage Syndrome (NBS) ; non-Hodgkin's lymphoma (NHL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Lymphoma and leukemia are the commonest malignantdiseases in patients with chromosomal breakage syndromes and immunodeficiency(Ataxia teleangiectasia (AT) and Nijmegen breakage syndrome (NBS)). Withimproved management of infections, malignant disease is more frequentlydiagnosed and has become one of the commonest causes of death in pediatric ATand NBS. Patients and methods:In three consecutive multicenter therapytrials for pediatric non-Hodgkin's lymphoma (NHL) (NHL-BFM), 1569 patientswith newly diagnosed NHL have been registered between 1986 and 1997. Ninepatients with AT (n = 5) and NBS (n = 4) were identified andanalysed. Results:Median age of patients with AT and NBS at diagnosis ofNHL was nine years. NHL-entities differed from non-AT/NBS-patients: diffuselarge B-cell lymphomas, n = 7 (78%); ALCL, n = 1;lymphoblastic T-cell lymphoma, n = 1. Cervical nodes, paranasalsinuses and epipharynx were the sites most frequently involved. Stages were:I and II in three patients, III in five and IV in one patient. All patientsreceived polychemotherapy according to tumor-entity and stage, none receivedradiation. Dose reductions according to individual tolerance concerned mainlyethotrexate, alkylating agents and epipodophyllotoxines. One patient died oftoxic complications, two patients relapsed and died, one patient suffered fromsecond malignancy. Five of nine patients are in 1. CCR after a medianfolluow-up of five years. Conclusions:Patients with AT and NBS suffer from rare entitiesof pediatric NHL. Curative treatment is possible and should be attempted.Intensity of therapy should be adjusted to individual risk factors andtolerance. Alkylating agents, epipodophyllotoxines should be omitted, dose ofMTX should be limited to 1 g/m2. Further cooperative trials usingstandardized approaches are required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008391923792
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  • 2
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    Ferenc Tökei: Zur marxistischen Geschichtstheorie (Book Review) (1978)
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 26:11 (1978) 1438 
    Details
    ISSN: 0012-1045
    Topics: Philosophy
    Notes: REZENSIONEN
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1978-026-11-000013
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  • 3
    Electronic Resource
    Electronic Resource
    Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 1-7 
    Details
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Preoperative chemo-therapy ; Limb salvage ; High dose methotrexate ; Interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuvant situation, therapy-limiting clinical conditions, or inadequate diagnosis. One hundred and fifty-one patients have been randomized to receive either the drug combination bleomycin+cyclophosphamide+dactinomycin (BCD) or cisplatinum (CPL) within a course of sequential multidrug chemotherapy including adriamycin (ADR) and high dose methotrexate (HDMTX). After exclusion of 51 patients with some deviation in history and/or management 100 selected patients were randomized once more to receive in addition or not fibroblast interferon after preoperative chemotherapy and surgical removal of the primary tumor. Patients were stratified for age and sex and for site and extension of tumor as well in both randomizations. Median follow up is now 12 (1–16) months. The expected 2-year disease free survival (DFS) rate of the total doubly randomized group is 78% and of the single randomized group 76%. No difference could be discerned between recombined groups receiving BCD vs CPL or interferon vs no interferon. The effect of preoperative chemotherapy on the tumor was evaluated clinically and by histopathologic grading; 66/85 (78%) patients were judged clinically as responders with pathohistologic verification of this finding in 71% of these cases. No adverse effect arose from delaying definite surgery for preoperative chemotherapy, but initial application of chemotherapy as well as planning, preparing, and performing of the surgical procedure have been facilitated. The majority of patients received some kind of limb-salvage treatment without local recurrences so far. A statistically insignificant but intriguing tendency for a slightly higher incidence of pulmonary metastases after resection as opposed to amputation could be detected. Similar to observations in the previous study COSS-77.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00625042
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  • 4
    Electronic Resource
    Electronic Resource
    Slight impairment of psychomotor skills in children after treatment of acute lymphoblastic leukemia (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 189-197 
    Details
    ISSN: 1432-1076
    Keywords: Acute lymphoblastic leukemia ; Cognitive functions ; Psychomotor speed ; School achievements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several studies have reported a decline in intelligence and cognitive functions in survivors of childhood acute lymphoblastic leukemia (ALL). Other investigators, however, have found no intellectual impairment in these children. Fifty-one long-term survivors of ALL, having been treated according to the protocols of the BFM Study Group from 1970 to 1979, were assessed retrospectively using neurophysical methods. The results were compared with those obtained from 30 patients with other malignancies, who had received neither radiation therapy to the central nervous system (CRT) nor any methotrexate during chemotherapy. Additionally, neurological examinations and cranial computed tomography (CCT) were performed. Neuropsychological examinations included verbal functions, intelligence (performance), psychomotor speed, motor skills and sensory integration. The results of verbal tests and the IQs, tested by nonspeed-related measures, were within normal limits in both groups. About one-third of all patients showed mild disturbances of psychomotor speed and motor skills. Children with leukemia had lower scores than those with solid tumors for nearly all tasks, but only tests for sensory integration revealed significant differences between former ALL patients and tumor patients. Furthermore, the following results were obtained related to different therapeutic modalities: (1) The higher total radiation doses had been during CRT (maximum 24 GY), the more neuropsychological functions were impaired, particularly motor accuracy and sensory integration. (2) These disturbances improved with the length of survival. Widening of subarachnoidal space was found in 33% of the CCT obtained. There was no correlation between the intellectual functions of the survivors and the CCT abnormalities. Neurological findings mainly consisted of slight fine motor disturbances. The results of the study suggest that psychomotor functions are more likely to be affected by antineoplastic therapy than are higher cognitive functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442447
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  • 5
    Electronic Resource
    Electronic Resource
    Successful treatment of pulmonary and cerebral aspergillosis in an immunosuppressed child (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 263-265 
    Details
    ISSN: 1432-1076
    Keywords: Invasive aspergillosis ; CNS-leukemia ; amphotericin B-5 ; Fluorocytosine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A favourable outcome was observed in a 12 year-old boy who developed invasive pulmonary and cerebral aspergillosis during antineoplastic treatment for central nervous system relapse of acute lymphoblastic leukemia. Combination therapy with amphotericin B and 5-Fluorocytosine led to complete regression of pulmonary infiltrates. Despite enlargement of the cerebral lesion monitored by computerized tomography, no viable fungi were found in the completely resected abscess after a 4 weeks' course of antifungal treatment preceeding neurosurgery. Histological examination confirmed the diagnosis of an aspergillotic abscess. The initially severe neurological symptoms disappeared after successful surgery. Aspergillus fumigatus was detected in the soil of a potted ornamental plant in the mother's living room, suggesting that this might have been the source of the infectious agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441214
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  • 6
    Electronic Resource
    Electronic Resource
    Über die simultane Bestimmung von Selen und Tellur im unteren ppb-Bereich durch Cathodic-Stripping-Voltammetrie (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 1-6 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Selen neben Tellur ; Voltammetrie, cathodic stripping ; simultan, ppb-Bereich
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Ein Verfahren der »cathodicstripping«-Voltammetrie wird beschrieben zur simultanen Bestimmung von Selen und Tellur im Bereich von 0,2–20 ppb Selen und 0,2–50 ppb Tellur. Die elektrolytische Anreicherung erfolgt potentiostatisch bei −0,4V (SCE) aus (NH4)2SO4-haltiger Grundlösung (pH 4,5) in Gegenwart von ÄDTA und CuCl2 an einem hängenden Quecksilbertropfen. Das Verfahren ist weitgehend störungsfrei und ermöglicht auch die Einzelbestimmung des Selens bzw. Tellurs in Gegenwart eines 104-fachen Überschusses des anderen Partners.
    Notes: Summary A “cathodic-stripping” voltammetric procedure for the determination of selenium and tellurium in the range of 0.2–20 ppb and 0.2–50ppb, respectively, is described. The electrolytical preconcentration on a hanging Hg-droplet is effected potentiostatically at −0.4 V (SCE) from a supporting electrolyte containing (NH4)2SO4 (pH4.5), in the presence of EDTA and CuCl2. The procedure is substantially free of interferences and enables also the single determination of selenium and tellurium in the presence of a 104-fold excess of the corresponding concomitant element.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490939
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  • 7
    Electronic Resource
    Electronic Resource
    1.1 Grundlagen, Methoden, Apparate, Reagentien, Automation, Datenverarbeitung (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 315 (1983), S. 147-153 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00488887
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  • 8
    Electronic Resource
    Electronic Resource
    2.4 Umweltrelevante Matrices (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 315 (1983), S. 162-165 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00488890
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  • 9
    Electronic Resource
    Electronic Resource
    2. Spezielle produkte und Anwendungsgebiete (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 314 (1983), S. 708-713 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00487364
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  • 10
    Electronic Resource
    Electronic Resource
    3. Biochemische und klinische Analyse (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 314 (1983), S. 722-730 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00487366
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