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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 3580-3582 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A theoretical model to predict the gate tunnel current in metal–oxide–semiconductor structures has been developed by employing the nonparabolic E-k dispersion for describing the tunneling electron momentum. The tunnel electron effective mass mox and the Fermi energy in the gate have been used to fit the calculated tunnel current to the measured one. It is shown that in the direct tunneling regime the tunnel electron effective mass mox apparently increases with decreasing oxide thickness presumably due to the reduction of Si–O–Si bond angle in the compressively strained layer near the SiO2/Si interface, while in the Fowler–Nordheim tunneling regime mox remains constant at 0.50 m0. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Keywords: Key words: MCP-1 – Macrophage infiltration – Neutrophil infiltration – IL-8 – LPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To evaluate the mechanism whereby monocyte chemoattractant protein (MCP)-1 attracts monocytes in vivo.¶Subjects: New Zealand white rabbits (175 rabbits) were used.¶Treatment: LPS, MCP-1 or IL-8 was injected into knee joints. Antibodies against various cytokines or IL-1 receptor antagonist were injected to neutralize cytokine activities.¶Methods: The numbers of leukocyte populations, levels of cytokines in joints were estimated.¶Results: Partial inhibition of neutrophil influx with anti-IL-8 IgG (10 μg) suppressed LPS-induced macrophage influx by 43 ± 8.5% (p〈0.05) without affecting the MCP-1 level. Intraarticular injection of MCP-1 (1-30 μg) induced macrophage influx. The event was accompanied by a small num-ber of neutrophils in an early phase. Co-injection of IL-8 (1.0 μg) enhanced the MCP-1-induced macrophage infiltration (p〈0.01). In neutrophil-deplete d rabbits, LPS failed to induce macrophage influx even though the MCP-1 level was maintained, and macrophage influx following exogenously administered MCP-1 was also dramatically inhibited.¶Conclusions: Early events associated with neutrophil infiltration appear to be important for MCP-1 to induce a later macrophage influx in LPS-arthritis.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: EEG ; Evoked potentials ; Newborn ; Intracranial hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The EEG, visual and auditory evoked potentials (VEP, AEP) were evaluated in 16 full-term newborn infants who had intracranial hemorrhage documented by computerized tomography (CT). Three of them had supratentorial, three, supra- and infratentorial hemorrhage, while the other ten had infra- or peri-tentorial bleeding. Three died during the neonatal period. Eight of the 13 surviving infants were neurologically normal and five were abnormal at the time of the follow-up. Those who had normal or mildly abnormal background EEGs all developed normally, while those whose neonatal EEG was severely abnormal subsequently developed neurological sequelae irrespective of the extent of intracranial hemorrhage. The EEG, VEP or AEP is of little value in the diagnosis of intracranial bleeding but the EEG is valuable in assessing the degree of associated parenchymatous damage and is of great prognostic significance.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1076
    Keywords: Infantile spasms ; Etiological factors ; Clinical aspects ; Long term prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The etiological factors, clinical aspects and long term prognosis were studied in 200 patients with infantile spasms. Forty-eight (24.0%) died and the rest were aged 6 years or more at the time of final follow-up. In 73 (36.5%) the etiology was prenatal, in 44 (22.0%) perinatal, and in 17 (8.5%) postnatal: 18 cases (9.0%) were cryptogenic. The remaining 48 (24.0%) patients were doubtful cases. The mortality of the pre-and perinatal cases at 35.6% and 34.1% respectively was significantly higher than that in the other etiologic groups (P〈0.001). With regard to the onset of spasms, these were very carly in the pre-and perinatal groups, whereas in the postnatal group the onset was late. The onset in the doubtful and cryptogenic groups was in between. Some 44.4% of the cryptogenic cases showed normal mental and physical development after the age of 6 years, whereas less than 10% of the prenatal and perinatal group did so. Almost all of the doubtful cases became mentally subnormal. The incidence of a family history of epilepsy or other convulsive disorders in the first, second and third degree relatives was highest in the cryptogenic cases (40.0%), and lowest in the perinatal cases (9.3%) (P〈0.01). The incidence of laughing attacks was highest in the postnatal cases (42.9%), against no such attacks in cryptogenic cases (P〈0.01). The attacks seemed to be linked with organic brain lesions. Among various factors related to the etiology of infantile spasms, genetic propensity seemed especially important in cryptogenic cases.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 44 (2000), S. 24-30 
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract  In this research, we hypothesized that, in rats, adaptation to high altitude (2500 m) plus training at low altitude (610 m), ”living high–training low”, improves physical performance at low altitude more than living and training at low altitude (610 m). Rats were divided into four groups: (1) living at low altitude (LL, n=12), (2) living and training at low altitude (LLTL, n=13), (3) living at high altitude (LH, n=12), (4) living at high altitude and training at low altitude (LHTL, n=13). The program for living at high altitude involved raising rats under hypobaric hypoxia (equivalent to 2500 m), and the training program consisted of running on a tread-mill at low altitude. All groups were raised at each altitude and trained to run at 35 m/min for 40 min/day, 6 days/week for 6 weeks. During this program, we measured heart rates both at rest and during exercise, and performed running-time trials. The mean heart rate during exercise was lower in groups with training than in groups without training, and the groups receiving training could run longer than the untrained groups. The LHTL group especially showed the lowest mean heart rate during exercise and the longest running time among all groups. After 6 weeks of the training program, all rats had a catheter implanted into the carotid artery, and the mean systemic arterial pressure was continuously measured during treadmill running. The rate of increase of this pressure as the running intensity increased was lower in groups with training than in groups without training, especially in the LHTL group. Finally, we anesthetized all the rats and extracted both the right and left ventricles, and the triceps surae and liver. Training increased the weight of the left ventricle, triceps surae, and liver. The increase in weight of the left ventricle and triceps surae was higher in the LHTL group than in the LLTL group in particular. It appeared that living high– training low may be an effective strategy to improve performance ability at low altitude.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0584
    Keywords: Keywords Immune thrombocytopenic purpura ; Intracranial hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We sent questionnaires to hospitals in Japan in order to study the incidence and conditions of intracranial hemorrhage (ICH) in children with immune thrombocytopenic purpura (ITP). From 1980 to 1995, 11 cases of ICH were reported in eight patients with ITP at 35 institutions. One patient had ICH four times, but only one patient died of the condition. From 1990 through 1995, ICH occurred in four (0.52%) of 772 patients with ITP. None of the patients died. The platelet count when ICH occurred was 5.2±3.7×109/l (mean±SD) (n=11). Four of the eight patients (1980–1995) had received active treatment [e.g. intravenous immunoglobulin G (i.v. IgG)] immediately before ICH occurred. In seven cases (1980–1995), possible causes of ICH, including menstruation (n=2) and viral infections (n=3), were identified. Systemic lupus erythematosus (SLE) later developed in three patients. Although the incidence of ICH in children with ITP has not decreased compared with the rates in earlier studies, the mortality rate has decreased markedly. Our results suggest that menstruation, infection, and risk factors for progression to SLE may help to predict ICH in children with ITP. Large-scale prospective trials are needed to identify risk factors for ICH.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 157 (2000), S. 2303-2322 
    ISSN: 1420-9136
    Keywords: Key Words: GPS, crustal deformation, the Japanese islands, data assimilation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —A GPS array with about 1,000 permanent stations is under operation in Japan. The GPS array revealed coseismic deformations associated with large earthquakes and ongoing secular deformation in the Japanese islands. Based on daily coordinate data of the GPS stations, strain rate distribution is estimated. Most regions with a large strain rate are related to plate boundaries and active volcanoes. In addition, the Niigata-Kobe Tectonic Zone (NKTZ) is recognized as a region of large strain rate along the Japan Sea coast and in the northern Chubu and Kinki districts. This newly found tectonic zone may be related to a hypothetical boundary between the Eurasian (or Amurian) and the Okhotsk (or North America) plates. Precise observation of crustal deformation provides important boundary conditions on numerical modeling of earthquakes and other crustal activities. Appropriate computation methods of continuous deformation field are directly applicable to data assimilation for such numerical simulations.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 21 (1983), S. 664-673 
    ISSN: 1741-0444
    Keywords: Clinical assessment ; Data processing ; Foot force ; Locomotion disability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A real need has existed for the development of simple, inexpensive, and yet functionally significant gait assessment systems that could be used in clinical practice. The paper describes a new scheme for the data processing of the output of a simple foot force measuring device previously reported by the authors. Only vertical forces exerted on the forefoot and the heel are measured continuously by the device. From these signals, the muscle moment acting on the ankle, the centre of pressure in one foot and the centre of pressure between both feet are calculated. Thus information on the muscle activities at the ankle and on the transfer of body weight in the progressional direction is derived. A brief description of the mathematical background is given first, and the clinical relevance of this method is discussed with several illustrations of preliminary results on normal and pathological subjects.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 22 (1984), S. 70-76 
    ISSN: 1741-0444
    Keywords: Correlation analysis ; Gait analysis ; Gait evaluation ; Pathological gait ; Quantitative indices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Although various methods have been proposed for quantitative evaluation of pathological gait, they are not yet widely used as routine clinical tools. The reasons are that measuring systems are too expensive and complicated and that the validity of the methods has not been fully examined in a statistical manner. In this paper, the validity of a new evaluation method based on a simple foot-force measuring device is investigated in terms of the correlation between quantitative indices and visually-rated grades. Forty-eight hemiparetic patients secondary to cerebral vascular accident walked on a 15 m straight level floor. Four people independently evaluated each subject in eight gait characteristics or items on a scale of 1–4 grades on the basis of visual inspection. These items include symmetry, variation, fluctuation, and dependence on the cane. At the same time, the vertical ground-reaction forces exerted on the right and left feet and on the cane were measured, and then quantitative indices representing these eight items were derived. All but one index shows a reasonably good correlation with the mean of the grades of the four observers. Thus, the feasibility of these indices is demonstrated. Statistical analysis also reveals several problems inherent in visual rating, such as inconsistency in the interpretation of evaluation criteria among observers, and a degradation of the independence of items owing to the observer’s subjectivity.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 22 (1984), S. 309-316 
    ISSN: 1741-0444
    Keywords: Capacitive transducer ; Error analysis ; Foot force ; Gait analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A capacitive transducer is developed which continuously measures the vertical component of foot forces during walking. The transducer is shaped like an insole and consists of two subtransducer units, the front and rear. The outputs of the two units are summed to give the total force exerted by the foot. Each unit has a multilayered structure. The basic layer is a 2 mm Neoprene sponge sheet sandwiched by two 50 μm copper foils. They as a whole form a capacitor. The other two layers are a driving shield and static shield, which minimise the effect of stray capacitance and power-line noise, respectively. The transducer is thin (3·8 mm), light (90 g) and flexible and so does not hinder the natural gait pattern. It can be attached to the sale of the shoe easily by elastic bands and Velcro straps. The accuracy of the transducer is well within ±10 per cent of the full scale. An error analysis is made to clarify the change in sensitivity owing to a localised foad. The results are used to compensate for the inherent nonlinearity of the transducer units.
    Type of Medium: Electronic Resource
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