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  • 1
    Electronic Resource
    Electronic Resource
    Topical treatment of common warts in an HIV-positive patient with imiquimod 5% cream (2003)
    Oxford, UK : Blackwell Publishing
    Clinical and experimental dermatology 28 (2003), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Human immunodeficiency virus (HIV) infects and destroys crucial components of the immune system, leaving patients susceptible to a number of viral, bacterial and fungal diseases. Viral warts are caused by human papillomavirus infection and are a common skin disease that afflicts HIV-infected patients. Treatment modalities currently rely on destruction of the infected tissue or interruption of cell division; however, frequent recurrence is a particular challenge in HIV-infected patients. We report the case of a 41-year-old HIV-positive man with multiple common warts located on his hands and feet. Following 5 months of treatment with imiquimod, an immune response modifier, as a 5% cream, complete clearance of all warts was achieved. Mild erythma, itching and burning at the application site was observed in the early stages of treatment. The patient showed no relapse of warts at the 30-month follow-up visit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.28.s1.16.x
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  • 2
    Electronic Resource
    Electronic Resource
    Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background  Matrix metalloproteinases (MMPs) contribute to matrix remodelling in venous leg ulcers. Extracellular MMP inducer (EMMPRIN; CD147) has been reported to increase MMP expression, and membrane type 1 MMP (MT1-MMP) has been implicated in the activation of MMPs. Objectives  To examine whether and to what degree EMMPRIN, MMP-2, MT1-MMP and membrane type 2 MMP (MT2-MMP) are expressed in venous leg ulcers as well as the association with MMP activity. Methods  EMMPRIN, MMP-2, MT1-MMP and MT2-MMP were analysed by zymography and immunohistochemistry in biopsies from healthy skin and lesional tissue from venous leg ulcers. Results  Zymography provided direct evidence of increased proteolytic activity of MMP-2 in lesional skin in comparison with healthy controls. Immunostaining showed intense expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP in dermal structures of venous leg ulcers, whereas only EMMPRIN and MMP-2 showed elevated expression in perivascular regions. Our findings indicate that venous leg ulcers are characterized by elevated expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP. The immunohistological findings of skin alterations reflect the dynamic process of activation of soluble and membrane-bound MMPs, which may be highly induced by EMMPRIN. Conclusions  These data suggest for the first time that membrane-bound MMPs may favour enhanced turnover of the extracellular matrix and support unrestrained MMP activity in venous leg ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.05025.x
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  • 3
    Electronic Resource
    Electronic Resource
    Inanspruchnahme medizinischer Versorgungsleistungen bei Patienten mit Fibromyalgiesyndrom (FMS) (2000)
    Springer
    Der Schmerz 14 (2000), S. 77-83 
    Details
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Fibromyalgiesyndrom ; Versorgungssituation ; Inanspruchnahme ; Patientenzufriedenheit ; Keywords Fibromyalgia syndrome ; Health care utilization ; Treatment satisfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: The purpose of the study was to examine the pain related health care utilization in patients with fibromyalgia syndrome. Methods: In a multicenter study six rheumatological hospitals associated in the rheumatological center of Heidelberg participated. All consecutive patients which fulfilled the ACR-criteria of fibromyalgia were assessed. Data about pain and related treatments were available from n=259 patients. Results: Patients suffered from chronic generalized pain on average for 5 years before being diagnosed as fibromyalgia. In most of the cases longlasting localized pain symptoms preceeded generalized pain. The spectrum of pain related treatments seems to be wide and arbitrary: 87% took questionable or excessive medication. 86% had some form of physiotherapy and 41% already experienced psychological treatment. 28% of the patients consulted dental surgeons including teeth extraction and 20% underwent multiple orthopaedic surgery. A mean of five different health care professionals were consulted regarding the pain problem. Treatment statisfaction rated by the patients was lowest with pharmacological and highest with psychological treatment and physiotherapy. Conclusions: The health care-seeking behavior of fibromyalgia-patients seems to be characterized by a multitude of different treatment attempts. Treatment was often invasive and focused on localized symptoms rather than on the generalized pain syndrome. An early confirmation of the diagnosis and a more evidence based treatment is strongly indicated.
    Notes: Zusammenfassung Fragestellung: Ziel der vorliegenden Studie ist die Analyse der Inanspruchnahme medizinischer Versorgungsleistungen von Fibromyalgiepatienten. Methode: Im Rahmen einer multizentrischen Erhebung in 6 Kliniken des Rheumazentrums Heidelberg wurden alle Patienten mit Fibromyalgiesyndrom (gemäß ACR 1990) hinsichtlich ihrer bisherigen Behandlungen befragt. Es liegen Daten von insgesamt n=259 Patienten vor. Ergebnisse: Im Durchschnitt hatten die Patienten bereits 5,4 Jahre vor der Diagnosestellung chronisch generalisierte Schmerzen (Diagnoselatenz). Dem Stadium der Schmerzgeneralisierung ging dabei ein über 10-jähriges Stadium lokalisierter Schmerzen voraus. Zahlreiche therapeutische Maßnahmen gegen die Schmerzsymptomatik wurden durchgeführt: 87% nahmen Medikamente – häufig eine fragwürdige Polymedikation. 86% erhielten aktive oder passive Physiotherapie und 41% wurden psychologisch behandelt. Bei 28% der Patienten wurde wegen der Schmerzen eine Zahnbehandlung durchgeführt. 20% wurden z. T. mehrfach orthopädisch operiert, nach der Schmerzgeneralisierung sogar signifikant mehr als vorher. Insgesamt wurden im Schnitt von den Patienten Ärzte in 5 verschiedenen Fachrichtungen konsultiert. Die Patienten selber beurteilten die medikamentöse Behandlung als am wenigsten hilfreich und passive Physiotherapie neben psychologischen Interventionen als am effektivsten. Schlussfolgerungen: Die Versorgungssituation der Patienten besteht aus einer Vielzahl unterschiedlicher Behandlungsversuche, welche jedoch eher auf lokalisierte Probleme als auf die generalisierte Schmerzsymptomatik abzielen. Eine frühzeitige Diagnosestellung und ein evidenzbasiertes Behandlungskonzept erscheinen dringend erforderlich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004820050225
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  • 4
    Electronic Resource
    Electronic Resource
    Changing hydrothermal activity in the Atlantis II Deep geothermal system (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 784-785 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We used the same instruments as for our previous temperature measurements7'8: first, a platinum high resistance thermo-probe as a semicontinuously recording instrument (Bathysonde T 83(3); and, second, deep-sea reversal thermometers. The reversal thermometers have been calibrated and their absolute ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274784a0
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  • 5
    Electronic Resource
    Electronic Resource
    Screening for and characterization of phospholipase A1 hypersecretory mutants of Tetrahymena thermophila (2000)
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 390-396 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract We have described a procedure for the isolation of mutants of Tetrahymena thermophila with hyperscretion of phospholipase A1 (PLA1). Using random chemical mutagenesis, uniparental cytogamy, genetic crossing and a new, fast and effective screening procedure, four PLA1-hypersecretory mutants were isolated. The screening procedure is based on the formation of a halo appearing around cylindrical holes in a lecithin-containing agar plate filled with cell-free supernatants. About 3,940 clones were tested with this procedure in primary screening for hypersecretory features, of which 60 putative hypersecretory mutants were isolated, subcloned and tested in a secondary screening. Of these, four selected mutants showed 1.8–2.2 more PLA1 activity in the cell-free supernatants compared to the wild-type strain CU 438.1. Hypersecretion was only observable for PLA1; no increased activity for two other lysosomal enzymes could be detected. These hypersecretory mutants of T. thermophila can be very useful for increasing the yield of PLA1 in fermentation processes. This is particularly relevant because, in contrast to other phospholipases, PLA1 is not available on the commercial market for fine chemicals and little is known about the role of PLA1 in cell signaling and metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530000405
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  • 6
    Electronic Resource
    Electronic Resource
    über das antigenetische Verhalten verschiedener Permanentzellstämme sowie über deren unterschiedliche Verwendbarkeit für die Gewinnung eines komplementbindenden Respiratory syncytial virus-Antigens (1970)
    Springer
    Medical microbiology and immunology 155 (1970), S. 275-282 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden Untersuchungen zur Gewinnung komplement-bindender RS-Virus-Antigene vorgelegt. Drei Problemstellungen wurden bearbeitet: 1. Das antigenetische Verhalten von Permanentzellstämmen. 2. Die Bestimmung von Antizelltitern in RS-Antiseren. 3. Die vergleichende Prüfung verschiedener RS-Virus-Antigene, die auf unterschiedlichen Zellstämmen präpariert wurden. Die günstigsten Resultate bezüglich der Präparation eines komplementbindenden RS-Antigens konnten bei Verwendung der ZellstämmeHelsi undFl in Kombination mit den VirusstämmenRandall undLong erzielt werden.
    Notes: Summary The preparation of the complement-fixing antigen of Respiratory syncytial virus (4 strains) from established cell lines (5 cell lines) is described. The following problems are discussed: 1. Determination of antigenic character of established cell lines. 2. Characterization of anticell titres from animal RS-antisera. 3. Comparative examination of different RS-virusantigens prepared on different established cell lines. The best results were obtained with the cell linesHelsi andFl in combination with the virus strainsRandall andLong.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02275113
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Boronierung von Polystyrol (1978)
    Springer
    Colloid & polymer science 256 (1978), S. 713-713 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784494
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  • 8
    Electronic Resource
    Electronic Resource
    Polymere mit dem Zentralatom eines Makrocyclus in der Hauptkette. 2. Mitt. Polykondensationsreaktionen mit Ge-Komplexen des Phthalocyanins und meso-Tetraphenylporphins (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 720-720 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550183
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  • 9
    Electronic Resource
    Electronic Resource
    Polymere mit dem Zentralatom eines Makrocyclus in der Hauptkette. 3. Mitt. Polykondensationsreaktionen mit Zn-Komplexen des meso-Tetraphenylporphins, Phthalocyanins und Hemiporphyrazins (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 829-829 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01664599
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  • 10
    Electronic Resource
    Electronic Resource
    Isotopieverschiebung der Bariumnuklide140Ba,138Ba,136Ba und134Ba in der Ba II-Resonanzlinie 6p 2 P 1/2-6s 2 S 1/2 (1974)
    Springer
    The European physical journal 267 (1974), S. 209-217 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The radioactive barium nuclide140Ba (T 1/2=12.8 d) has been separated chemically from fission products of uranium. The scheme of the carrier-free separation is described. The isotope shift in the barium II resonance line 6p 2 P 1/2-6s 2 S 1/2,λ=4934 Å has been measured by means of a pressure scanned Fabry-Pérot interferometer. The resultΔv(140Ba-138Ba)=−39.3 (3.2)mK has been used together with the remeasured isotope shift values of138Ba,136Ba, and134Ba to calculate the change of the mean square radius of the nuclear charge distributionδ〈r 2〉. The results are compared with data for isotonic nuclides of neighbouring elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01669222
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