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  • 2000-2004  (1)
  • 1975-1979  (2)
  • 1950-1954
  • Computational Chemistry and Molecular Modeling  (1)
  • Dopamine-receptor agonist/antagonist  (1)
  • Nerve, optic  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Psychopharmacological studies on (-)-nuciferine and its Hofmann degradation product atherosperminine (1978)
    Springer
    Psychopharmacology 59 (1978), S. 29-33 
    Details
    ISSN: 1432-2072
    Keywords: Aporphine alkaloid and derived arylethylamine ; Nuciferine ; Neuroleptic ; Atherosperminine ; Dopamine-receptor agonist/antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (-)-Nuciferine and its Hofmann degradation product atherosperminine showed divergent psychopharmacological effects. Because nuciferine has been reported to be a neuroleptic and atherosperminine has some chemical resemblance to dopamine, they were investigated for their dopamine-receptor activities. Nuciferine had a pharmacologic profile of action associated with dopamine-receptor blockade; i.e., it induced catalepsy, inhibited spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. On the other hand, atherosperminine produced effects associated with dopamine receptor stimulation, i.e., stereotypy, increase in spontaneous motor activity and amphetamine toxicity, reversal of haloperidol-induced catalepsy and inhibition of conditioned avoidance response, inhibition of morphine analgesia, and potentiation of the anticonvulsant action of diphenylhydantoin. The results are discussed on the basis of the chemical configuration of the two compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428026
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    MRI of the intraorbital optic nerve in patients with autosomal dominant optic atrophy (2000)
    Springer
    Neuroradiology 42 (2000), S. 180-183 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Nerve, optic ; Optic atrophy, dominant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Measurements of the intraorbital optic nerve were made using high-resolution coronal MRI in 10 adults with autosomal dominant optic atrophy. Comparisons were made with previous studies of 10 normal adult subjects. The cross-sectional diameters of the optic nerve and the perineural subarachnoid space were measured and a ratio of there diameters at anterior, mid and posterior positions along the optic nerve was determined. We found a statistically significant difference in the mean optic nerve: sheath ratio between the control group and patients with autosomal dominant optic atrophy. At anterior, mid and posterior locations along the optic nerve it is significantly smaller in patients with optic atrophy. We have demonstrated that the loss of ganglion cells, previously documented in dominant optic atrophy, is associated with a significant loss of optic nerve tissue and thinning of the nerve along its length.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050041
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Orbital optimization techniques: Comparative study in a semiempirical framework (1978)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 14 (1978), S. 289-297 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this paper, MC-SCF and CI methods have been explored for the calculation of ground- and excited-state energies of some aromatic heterocycles in the PPP framework. A new algorithm for solving the orbital equations in MC-SCF theory has been suggested and its performance has been compared with the conventional gradient optimization technique. Energies of first few transitions have been calculated and compared with rather extensive CI results.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560140307
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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