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  • 1
    Electronic Resource
    Electronic Resource
    IgM antibodies to cytomegalovirus during pregnancy (1977)
    Springer
    Archives of virology 53 (1977), S. 177-184 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary IgM antibodies to cytomegalovirus (CMV) could be detected in about 7 per cent of 629 pregnant women, whereas in 225 nonpregnant control women of similar age distribution only 2.6 per cent showed CMV IgM antibodies. Intrauterine CMV infections were almost exclusively detected among the CMV IgM positive gravides. The high incidence of CMV IgM antibodies in pregnant women can be possibly explained by an increased rate of CMV reactivations during pregnancy. We were able to show that during CMV reactivation an intrauterine infection might occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314662
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neutralizing serum IgM antibodies in infections withHerpes simplex virus hominis (1976)
    Springer
    Medical microbiology and immunology 162 (1976), S. 183-192 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Forty-two patients with herpes simplex virus infections were tested for neutralizing serum IgM antibodies. A technique in which serum antibody fluorescein staining was combined with sucrose gradient centrifugation facilitated the isolation of the serum IgM fraction for the use in neutralization tests. In nearly all cases with primary infection, especially those presenting heavy clinical signs (encephalitis/meningitis) the IgM tests were positive. In one case we could detect the IgM antibodies for 11 weeks after the onset of the illness, in another case in cerebrospinal fluid samples for 6 weeks. In localized herpes infections, which were mostly due to reactivations, serum IgM antibodies could only rarely be demonstrated. Among the serologic tests used in this study (NT, CFT, IFT, ACIFT), only the CFT beside the NT (with certain reservations) can be applied for subtyping HSV serum antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02120996
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Envelope and nucleocapsid antigens of Cytomegalovirus (CMV) (1975)
    Springer
    Medical microbiology and immunology 161 (1975), S. 155-162 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method for the purification and concentration of Cytomegalovirus nucleocapsids and particles complete with envelope is described. Antibody to either nucleocapsid or envelope antigens can be detected in human sera. In patients with CMV disease the antibodies to the envelope antigen could not be detected before the 3rd week after the beginning of disease whereas antibodies to the nucleocapsid were detected earlier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121005
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Activity of Cellular Thymidine Kinase 1 in PBMC of HIV-1-Infected Patients: Novel Therapy Marker (2000)
    Springer
    Infection 28 (2000), S. 209-213 
    Details
    ISSN: 1439-0973
    Keywords: Key Words Cellular resistance ; TK1 activity ; HIV-1 ; Zidovudine ; Antiretroviral therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cellular cytoplasmatic thymidine kinase 1 (TK1) catalyzes the intracellular phosphorylation of anti-HIV-1 nucleoside analogs zidovudine (AZT) and stavudine (d4T) to the corresponding monophosphate form. In HIV-1-infected patients, treated with combination therapy including one of these compounds for more than 1 year, enzymatic activity of TK1 in peripheral blood mononuclear cells (PBMC) was determined by radioactive assay. TK1 activity in PBMC of HIV-1-infected patients correlated with CD4 cell count (r = 0.4, p 〈 0.05) and HIV-1 RNA copy number (r = 0.4, p 〈 0.05), being lower in patients with decreased CD4 cell count and high viral load. Furthermore, TK1 activity differs between HIV-1-infected individuals treated for more than 6 months (13.5 pmol/mg/h) compared to patients treated for less than 6 months (28.1 pmol/mg/h; p 〈 0.05) with chemotherapeutic agents including thymidine analogs. The results demonstrate that TK1 deficiency in PBMC of HIV-1 infected patients may develop due to continuous treatment with thymidine analogs and correlates with a more progressed stage of disease expressed as diminished CD4 cell count and increased viral load.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s150100070037
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Elevated Plasma Levels of 90K (Mac-2 BP) Immunostimulatory Glycoprotein in HIV-1-Infected Children (2000)
    Springer
    Journal of clinical immunology 20 (2000), S. 117-122 
    Details
    ISSN: 1573-2592
    Keywords: Human immunodeficiency virus type 1 (HIV-1) ; 90K (Mac-2BP) ; viral load ; progression markers ; immune system activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 μg/ml) were higher than in HIV-1 uninfected control group (6.3 μg/ml; P 〈 0.05). 90K levels of HIV-1-infected children classified as stage B and C (median, 15.0 μg/ml and 22.7 μg/ml, respectively) were higher compared to children with stage A disease (median, 7.0 μg/ml; P 〈 0.05). A positive correlation (r = 0.5; P 〈 0.05) was found between 90K levels and HIV-1 RNA levels in 137 plasma samples of 18 HIV-1-infected children collected during a period of 1 year. No correlation was found between 90K levels and CD4 cell counts. These results suggest that 90K plasma levels may represent a novel marker of disease progression in HIV-1-infected children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006634530672
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Simple method to detect virus-specific IgM antibodies in patients' serum samples after immunosorption of immunoglobulins G and A (1979)
    Springer
    Medical microbiology and immunology 167 (1979), S. 77-82 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract By absorption with protein A and specific immunosorption using insolubilized adsorbentia (CPG), a method was developed for rapid elimination of IgG and IgA from patients' serum samples. This test technique was examined in the diagnosis of rubella infections, i.e., rubella-specific IgM antibodies. The procedure has proven to be as reliable as determinations carried out with IgM fractions separated on a sucrose density gradient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123557
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    Paper (German National Licenses)
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