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  • 1
    Electronic Resource
    Electronic Resource
    Magnetic field dependence of spin-glass freezing temperature in a diluted antiferromagnet Mn0.55Mg0.45TiO3 (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 7053-7055 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In order to examine magnetic properties of a spin-glass Mn0.55Mg0.45TiO3 under magnetic fields, dc magnetization, ac susceptibility, muon spin relaxation (μSR), and neutron scattering measurements have been performed. A freezing temperature observed by the dc magnetization and the ac susceptibility strongly depends on magnetic field, H. But for the latter, the H dependence becomes weak, as the measuring frequency increases. In the μSR and the neutron scattering measurements, no significant field dependence is observed. These results demonstrate that the field dependence of the freezing temperature becomes weaker, as the time scale of measurements shortens. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1358341
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  • 2
    Electronic Resource
    Electronic Resource
    Dystrophic scrotal calcinosis originating from benign eccrine epithelial cysts (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Scrotal calcinosis has been classified as a form of idiopathic calcinosis cutis. However, the pathogenesis of the calcified nodules has not been fully elucidated: it is still unclear whether the condition is truly idiopathic, or the result of breakdown of calcified epithelial cysts. We describe a 29-year-old Japanese patient with scrotal calcinosis originating from epithelial cysts. Light microscopy revealed a large epithelial cyst containing von Kossa-positive material and several small dilated ductal structures beside the cyst. The epithelia of the cyst and ductal structures were connected, showing similar eccrine duct differentiation on immunohistochemical staining and electron microscopy. In the cyst lumen, calcium was present as needle-shaped crystals. The pathogenetic mechanism of calcium deposition seemed to be due to excessive production and discharge of matrical debris and sulphated mucopolysaccharides, which derived from luminal cells, and their accumulation in the lumina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.03965.x
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  • 3
    Electronic Resource
    Electronic Resource
    Chronic glomerulonephritis remarkably improved after surgery for acne conglobata of the buttocks (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04362.x
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  • 4
    Electronic Resource
    Electronic Resource
    Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  To demonstrate the antitumour effects of nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone), a citrus flavonoid extracted from Citrus depressa Hayata, on human gastric cancer cell lines TMK-1, MKN-45, MKN-74 and KATO-III.Materials and methods:  3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the TdT-mediated dUTP biotin nick-end labelling (TUNEL) method and cell-cycle analysis revealed that nobiletin acted on these cells in several ways, namely by direct cytotoxicity, induction of apoptosis and modulation of cell cycle. The efficacy of combined treatment of nobiletin with a conventional anticancer drug, CDDP, was also examined. Treatment with nobiletin 24 h prior to CDDP administration showed a synergistic effect compared to the control.Conclusions:  Although the effective dose and administration route of nobiletin require further investigation, our study represents a potential successful linking of this compound with the treatment of gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.02082.x
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  • 5
    Electronic Resource
    Electronic Resource
    A unique case of sarcoidosis: coexistence of sarcoidal granuloma and histological changes consistent with dermatomyositis (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05448.x
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  • 6
    Electronic Resource
    Electronic Resource
    On the high energy proton spectrum measurements (1977)
    Springer
    Astrophysics and space science 52 (1977), S. 415-427 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Résumé L'accroissement avec l'énergie de l'albedo dû au calorimètre peut expliquer l'augmentation de la pente du spectre primaire de protons au-delà de 1000 GeV et la croissance des sections efficaces inélastiques entre 20 et 600 GeV observés lors des expériences en satellite PROTON 1, 2 et 3.
    Notes: Abstract The steepening of the proton spectrum beyond 1000 GeV and the rise in inelastic cross sections between 20 and 600 GeV observed by the PROTON 1-2-3 satellite experiments may be explained by systematic effects of energy dependent albedo (back-scatter) from the calorimeter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01093876
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  • 7
    Electronic Resource
    Electronic Resource
    A major metabolite of aceclofenac, 4′-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells (2000)
    Springer
    Inflammation research 49 (2000), S. 133-138 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Aceclofenac — 4′-Hydroxy aceclofenac — Pro-matrix metalloproteinase 1 — Pro-matrix metalloproteinase 3 — Rheumatoid synovial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We examined the effects of aceclofenac and its metabolites on the production of pro-collagenase-1/pro-matrix metalloproteinase-1 (proMMP-1), pro-gelatinase A/proMMP-2, pro-stromelysin-1/proMMP-3 and tissue inhibitor of metalloproteinases-1 (TIMP-1) by rheumatoid synovial cells.¶Materials: Synovial cells were obtained from patients with rheumatoid arthritis.¶Treatment: Cultures of confluent cells were treated with interleukin-1β (IL-1β)(1 ng/ml) and/or test drugs (0.3-30 μM) for 48 h.¶Methods: Production of proMMPs and TIMP-1 was monitored by Western blotting or gelatin zymography. Prostaglandin E2 (PGE2) was measured by an enzyme immunoassay.¶Results: 4′-Hydroxy aceclofenac, a major metabolite of aceclofenac, down-regulated both basal and IL-1β-induced production of proMMP-1 and proMMP-3 at a concentration sufficient to suppress PGE2 production without modulating proMMP-2 or TIMP-1, whereas aceclofenac itself had no marked effect on the production of proMMPs.¶Conclusions: Down-regulation of proMMP-1 and proMMP-3 production by 4′-hydroxy aceclofenac may contribute to the therapeutic effect of aceclofenac on rheumatoid arthritis and osteoarthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050571
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  • 8
    Electronic Resource
    Electronic Resource
    The definition of “Cheyne-Stokes rhythms” (1978)
    Springer
    Acta neurochirurgica 43 (1978), S. 61-76 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The review of the literature on Cheyne-Stokes respiratory periods reveals enormous variation of the opinions expressed. The original description concerned periodicity characterized by rhythmic changes of respiratory phases and respiratory pauses in a relation of 60 ∶ 15 seconds. In the respiratory phase there were 30 respirations of increasing depths and frequency at the beginning of the phase and decreasing depths and frequency at the end of the phase. Literature data about Cheyne-Stokes respiration comprise a multiplicity of all rhythmic forms. The duration of respiratory cycles varies between 12 and 130 seconds. The relation of the respiratory phase and respiratory pause between 6 ∶ 4 or 75 ∶ 70 seconds, and the number of breaths between 3 and 30 during one respiratory phase. Cheyne-Stokes periods were observed in healthy subjects as well as in patients with neurological, neurosurgical, cardiac, pulmonary and paediatric diseases. Cheyne-Stokes periods were explained as sequel of prolongation of circulation time between pulmonary alveoli and respiratory centre, through increased sensitivity of the respiratory centre to CO2, diminished sensitivity of the respiratory centre to CO2 and O2-deficit, local blood flow disturbances, section of pathways in the brain stem with disinhibition of basic rhythms, brain immaturity, alterations of consciousness, and respiratory obstructions. Rhythmic changes of the heart beat, of excitability of the heart muscle, of blood pressure, of EEG and of neurological and mental signs were observed. In spite of numerous observations detailed analysis of the respiratory cycle was performed in only a few cases. Major studies are lacking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809226
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  • 9
    Electronic Resource
    Electronic Resource
    Duration of the respiratory periods of uniform respiratory rhythms in 35 patients with neurosurgical diseases (1978)
    Springer
    Acta neurochirurgica 43 (1978), S. 77-91 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Analysis of uniform respiratory rhythms in 35 neurosurgical patients showed that the mean duration of respiratory periods was between 8.60 and 71.51 seconds. The scatter around the mean value increases with the increase of the duration of the respiratory period. For an individual patient there is a one-peak distribution of the duration of respiratory periods. The duration of respiratory periods increases with age. There is a group of patients in whom the respiratory periods last over 40 seconds. This group is difficult to classify. There are no correlations between the acid-base values, blood gas values, and the duration of respiratory periods. Analysis of 10 autopsy cases showed lesions in the brain stem without any particular prevalence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809227
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  • 10
    Electronic Resource
    Electronic Resource
    Variability of the respiratory phase, respiratory pause, and numbers and durations of respirations during periodic breathing (1978)
    Springer
    Acta neurochirurgica 43 (1978), S. 263-274 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The analysis of cycles of periodic breathing (Cheyne-Stokes rhythms) in 35 patients showed wide variability of mean values of respiratory phases. The respiratory pauses are usually shorter and the scatter of the mean values is smaller. Only in four cases were respiratory pauses longer than respiratory phases. The duration of the respiratory phase becomes extended through the increase of number of single respirations. The latter also shows a very small scatter. The respiratory rate in 32 out of 35 patients was higher than normal and is to be considered as tachypnoea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01587961
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