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  • 2000-2004  (3)
  • 1975-1979  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Induction of Suppressor Activity on B-Cell Differentiation in Human T-Cell Subset without Fc(IgG) Receptors by Levamisole Administration (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 10 (1979), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A single oral dose of 150 mg levamisole was administered to five healthy adults. Circulating Fc(IgG) receptor-bearing T cells (Tγ cells) increased for 5 days after levamisole intake, but total E rosette-forming cells showed no significant alterations. The generation of immunoglobulin-producing cells in the peripheral blood lymphocytes (PBL), which was induced in the in vitro pokeweed mitogen (PWM)-stimulated cultures, was significantly suppressed for 5 days after levamisole administration. Suppressor T-cell activity on B-cell differentiation, which was induced by levamisole intake, was evaluated by co-culturing with allogeneic untreated adult PBL in the PWM system in six other volunteers. A seemingly dose-dependent suppression on B-cell differentiation was exerted by T cells isolated on day 3 of levamisole treatment, but not by T cells which were isolated before or on day 14 of the experiment. When T cells were fractionated into two subsets with regard to the presence or absence of Fc(IgG) receptors, suppressor T-cell activity appeared to be generated by levamisole largely in T cells lacking Fc(IgG) receptors, but not in Tγ cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1979.tb01387.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transient Increase of IgG Fc Receptor-Bearing T Lymphocytes following Positive PPD Skin Testing (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In tuberculin-sensitive individuals, IgG Fc receptor (FcR)-hearing lymphocytes in the peripheral blood increased transiently following PPD-tuberculin skin test. This rise in circulating FcR-bearing cells appeared to peak about 36–48 h after the intradermal inoculation of PPD and seemed to occur largely in the T cell population. Skin test-negative individuals showed no significant changes in their circulating FcR-bearing cells following PPD inoculation. Peripheral blood lymphocytes from PPD-sensitive individuals were fractionated into non-T cell and T cell-enriched populations by E rosette sedimentation technique. FcR-bearing cells in the T cell-enriched population were eliminated by EA rosette sedimentation: i. e. FcR-negative T cells. Then, equal numbers (1 × 105 cells each) of non-T cells and unfractionated or FcR-negative T cells were recombined in culture. Prior to PPD inoculation, there was no significant difference between these two cell mixtures in the in vitro cellular response to PPD or mitogens. When these cell populations were obtained. 16–48 h after PPD inoculation, however, the combination of non-T tells and FcR-negative T cells responded to PPD much better than the combination of non-T cells and unfractionated T cells, whereas the mitogen-induced cellular proliferation of these two cell mixtures did not differ from each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1978.tb00510.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Heterosis for neonatal survival in the guppy (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 60 (2002), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Neonatal survival rate ranged from 91.8 to 100.0% in 12 populations of the guppy Poecilia reticulata, and was higher in naturalized Japanese stream populations than in domestic strains. Mean heterozygosity at five allozyme and four microsatellite loci varied between 0.112 and 0.430 and was significantly correlated with neonatal survival rate among populations, suggest ing that inbreeding decreases neonatal survival. Diallel and reciprocal crosses among four domestic strains demonstrated heterosis for neonatal survival. These results indicate that neonatal survival is genetically affected by heterosis and its antithesis, inbreeding depression. The relationship between neonatal survival and the mean heterozygosity suggests that overall heterozygosity is important for neonatal survival of the guppy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.2002.tb01695.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: evidence for early involvement of glycation in motoneuron diseases (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 63-66 
    Details
    ISSN: 1432-0533
    Keywords: Key words Glycation ; Amadori product ; Amyotrophic lateral sclerosis ; Spinobulbar muscular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glycation is a series of non-enzymatic reactions initiated by addition of reducing sugars to ɛ-amino group of lysine residues and α-amino group of the N terminus of proteins, leading to the formation of advanced glycation end products (AGE). It is thought to be involved in aging and various neurodegenerative conditions. In the present study using anti-1-hexitol-lysine (1-HL) antibody, Amadori product, an early glycation product, was detected in axonal spheroids in the anterior horn of amyotrophic lateral sclerosis and in atrophic neurons of spinobulbar muscular atrophy (SBMA, Kennedy disease with abnormally expanded triplet repeats in androgen receptor gene) but not in other regions of the central nervous system. Furthermore, Amadori product was undetectable in the tissues from age-matched controls. Thus, 1-HL formation could not reflect physiological aging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007407
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Particle image velocimetry and planar laser-induced fluorescence measurements on lobed jet mixing flows (2000)
    Springer
    Experiments in fluids 29 (2000), S. S141 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  An experimental investigation of the vortical and turbulent structures in lobed jet mixing flows was conducted. The techniques of planar laser-induced fluorescence (PLIF) and particle image velocimetry (PIV) were used to accomplish flow visualisation and velocity filed measurements of the lobed jet mixing flows. Compared with a conventional circular jet flow, the lobed jet mixing flows were found to have a shorter laminar region, a smaller scale of spanwise Kelvin–Helmholtz vortices, quicker transition to turbulence and earlier appearance of small-scale vortical and turbulent structures. The intensive mixing of the core jet flow with ambient flow was found to concentrate within the first two nozzle diameters in the lobed jet mixing flow. More rapid growth of the shear layer at the near field and quicker decay of the central line velocity were also found in the lobed jet mixing flow. All these indicated a better mixing enhancement performance of the lobed nozzle compared with the conventional circular nozzle in the near-field region. Based on the PLIF and PIV results, two aspects of the mechanism of mixing enhancement in a lobed jet mixing flow were suggested. One is that a lobed nozzle can cause big azimuthal perturbations in the jet flow due to its special geometry, and the streamwise vortices produced by the lobed nozzle can enhanced the azimuthal perturbations. The “cut and connect” process of the large-scale spanwise Kelvin–Helmholtz vortex rings was accelerated. This is responsible for the avalanche of three-dimensional and smaller-scale motions and the generation of high turbulence. Another is that the “stretch effect” of streamwise vortices generated by the lobed nozzle on the spanwise Kelvin–Helmholtz vortical rings reduced the scale of the spanwise Kelvin–Helmholtz vortices, which also results in the creation of much small-scale intense turbulence and enhances the mixing of the core jet flow with the ambient flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003480070016
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    Paper (German National Licenses)
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