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  • 1
    Electronic Resource
    Electronic Resource
    Dioxolenium ion trapping in the hydrolysis of cyclic ortho esters: the rate-determining step (1979)
    s.l. : American Chemical Society
    The @journal of organic chemistry 44 (1979), S. 619-622 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01318a028
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear diagnostics for the National Ignition Facility (invited) : Papers from the thirteenth topical conference on high temperature plasma diagnostics (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 773-779 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, will provide unprecedented opportunities for the use of nuclear diagnostics in inertial confinement fusion experiments. The completed facility will provide 2 MJ of laser energy for driving targets, compared to the approximately 40 kJ that was available on Nova and the approximately 30 kJ available on Omega. Ignited NIF targets are anticipated to produce up to 1019 DT neutrons. In addition to a basic set of nuclear diagnostics based on previous experience, these higher NIF yields are expected to allow innovative nuclear diagnostic techniques to be utilized, such as neutron imaging, recoil proton techniques, and gamma-ray-based reaction history measurements. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1319356
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  • 3
    Electronic Resource
    Electronic Resource
    Transformation of MCF-10A Human Breast Epithelial Cells by Zeranol and Estradiol-17β (2004)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 10 (2004), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Among the endocrine factors associated with breast cancer, estrogens are considered to play a central role in human breast carcinogenesis. Breast cancer risks are increased by long-term exposure to estrogens. Zeranol (Ralgro) is a nonsteroidal agent with estrogenic activity that is used as a growth promoter in the U.S. beef and veal industry. To determine whether zeranol and estradiol-17β play a role in the neoplastic transformation of human breast and to compare the estrogenic potency of zeranol to that of estradiol-17β in human breast, we treated human breast epithelial cell MCF-10A with different doses of zeranol or estradiol-17β for 10 repeated treatment cycles. By utilizing the doubling time assay, soft agar assay, and reverse transcriptase polymerase chain reaction (RT-PCR) assay, we showed that 10 repeated estradiol-17β or zeranol treatment cycles to MCF-10A cells decrease the doubling time of the cells by 30 to 40% and stimulate colony formation in soft agar and induce estrogen receptor β (ER-β) mRNA expression, all of which are not dose related in our tested dose range. Furthermore, we show that zeranol and estradiol-17β have a similar potency in the stimulation and inhibition of gene expressions in human breast cancer cell line MCF-7 by RT-PCR. These results indicate that both zeranol and estradiol-17β can induce human breast epithelial cell neoplastic transformation with similar potency in the long-term exposure through the oxidation-reduction (redox) pathway and/or ER-β-mediated pathway. 
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1075-122X.2004.21410.x
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  • 4
    Electronic Resource
    Electronic Resource
    Minocycline inhibits apoptotic cell death via attenuation of TNF-α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 91 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We attempted to ascertain the neuroprotective effects and mechanisms of minocycline in inflammatory-mediated neurotoxicity using primary neuron/glia co-cultures treated with lipopolysaccharide (LPS). Neuronal cell death was induced by treatment with LPS for 48 h, and the cell damage was assessed using lactate dehydrogenase (LDH) assays and by counting microtubule-associated protein-2 (MAP-2) positive cells. Through terminal transferase deoxyuridine triphosphate-biotin nick end labeling (TUNEL)-staining and by measuring caspase-3 activity, we found that LPS-induced neuronal cell death was mediated by apoptosis. We determined that pre-treatment with minocycline significantly inhibited LPS-induced neuronal cell death. In addition, LPS induced inducible nitric oxide synthase (iNOS) expression significantly, resulting in nitric oxide (NO) production within glial cells, but not in neurons. Both nitric oxide synthase (NOS) inhibitors (NG-monomethyl-l-arginine monoacetate (l-NMMA) and S-methylisothiourea sulfate (SMT)) and minocycline inhibited iNOS expression and NO release, and increased neuronal survival in neuron/glia co-cultures. Pre-treatment with minocycline significantly inhibited the rapid and extensive production of tumor necrosis factor-alpha (TNF-α) mediated by LPS in glial cells. We also determined that the signaling cascade of LPS-mediated iNOS induction and NO production was mediated by TNF-α by using neutralizing antibodies to TNF-α. Consequently, our results show that the neuroprotective effect of minocycline is associated with inhibition of iNOS induction and NO production in glial cells, which is mediated by the LPS-induced production of TNF-α.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02780.x
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of nitrate and nitrite in whey powder (1979)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 27 (1979), S. 1277-1279 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60226a043
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  • 6
    Electronic Resource
    Electronic Resource
    Prediction of Future Nitrate Concentrations in Ground Water (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 14 (1976), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Over the last few years rises in the nitrate content of ground water from wells and springs in the principal aquifers of the United Kingdom have been observed. In a number of cases the concentrations have exceeded the WHO lower recommended limit. In order to determine the reason for the rise, to assess whether it will continue and the eventual nitrate levels, the Water Research Centre has undertaken an extensive programme of drilling and sampling on the Chalk and Bunter Sandstone, and by August 1976, twenty-two sites had been examined. This work has established that high nitrate concentrations (peaks up to 60 mg/l NO3-N have been observed) are present in the unsaturated aquifers at fertilized arable/ley sites. At unfertilized grassland sites nitrate concentrations are low (less than 4 mg/l NO3-N) and below fertilized established grassland values are in the intermediate range. At one farm site near Winchester, models to predict the rate of movement of nitrate through the unsaturated and saturated Chalk have been developed. These suggest that the nitrate levels at this site will remain at an essentially constant value of about 4 mg/l NO3-N until the late 1970's when they will rise progressively to about 4 mg/l NO3-N. The models have been checked against tritium data and the approach is now being extended to other sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1976.tb03136.x
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  • 7
    Electronic Resource
    Electronic Resource
    EXTENSIVE MYCETOMA IN A BLACK SOUTH AFRICAN (1977)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 16 (1977), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1977.tb01898.x
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  • 8
    Electronic Resource
    Electronic Resource
    Gas-liquid critical properties of binary mixtures (1975)
    s.l. : American Chemical Society
    Chemical reviews 75 (1975), S. 119-175 
    Details
    ISSN: 1520-6890
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/cr60294a001
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  • 9
    Electronic Resource
    Electronic Resource
    Protein nutritional quality of Florunner peanut meal as measured by rat bioassay (1977)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 25 (1977), S. 653-657 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60211a051
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  • 10
    Electronic Resource
    Electronic Resource
    Isothermal binodal curves near a critical endpoint (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 933-950 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Thermodynamics in the vicinity of a critical endpoint with nonclassical exponents α, β, γ, δ, ... , is analyzed in terms of density variables (mole fractions, magnetizations, etc.). The shapes of the isothermal binodals or two-phase coexistence curves are found at and near the endpoint for symmetric and nonsymmetric situations. The spectator- (or noncritical-) phase binodal at T=Te is characterized by an exponent (δ+1)/δ ((similar, equals)1.21) with leading corrections of relative order 1/δ ((similar, equals)0.21), θ4/βδ ((similar, equals)0.34) and 1−(βδ)−1 ((similar, equals)0.36); in contrast to classical (van der Waals, mean field, etc.) theory, the critical endpoint binodal is singular with a leading exponent (1−α)/β ((similar, equals)2.73) and corrections which are elucidated; the remaining, λ-line binodals also display the "renormalized exponent," (1−α)/β but with more singular corrections. [The numerical values quoted here pertain to (d=3)-dimensional-fluid or Ising-type systems.] © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1373665
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