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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 50 (1985), S. 4360-4362 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 390-391 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 2027-2028 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 8 (2001), S. 3724-3733 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This article describes 250, 280, and 350 eV drive temperature copper-doped Be [Be(Cu)] two-dimensional (2-D) capsule-hohlraum designs for the National Ignition Facility (NIF) [Paisner et al., Laser Focus World 30, 75 (1994)]. These capsule-hohlraum designs are a follow-on to the previous one-dimensional capsule designs of Bradley and Wilson [Phys. Plasmas 6, 4293 (1999)]. It is shown that a 2-D 350 eV capsule-hohlraum design scaled from the successful 330 eV design does not ignite, mostly due to poor symmetry. In addition, the 350 eV capsule hohlraum design requires the full 500 TW of the NIF design and 1.66 MJ of the maximum 1.8 MJ designed energy output. It is possible to design a capsule-hohlraum combination that achieves ignition and burn with peak radiation temperatures of 250, 280, and 330 eV. These designs use from 1.3 to 1.6 MJ of laser energy and the successful designs have yields of 16–20 MJ. Changes in symmetry and yield due to changing the focal point of the inner and outer laser cones were examined. The 280 eV capsule can tolerate pointing changes of 40–100 μm before the yield drops by 50%, while even a 40 μm pointing change for the 250 eV capsule causes the yield to drop by a factor of 2 to 100. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 6 (1999), S. 4293-4303 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This article describes a suite of 250, 280, and 350 eV copper-doped Be [Be(Cu)] capsule designs for the National Ignition Facility [Paisner et al., Laser Focus World 30, 75 (1994)] and compare these to previous Be(Cu) and bromine-doped CH plastic [CH(Br)] capsule designs for 300 and 330 eV drives. These capsule designs are constrained to have the same deuterium-tritium (DT) fuel mass as the 300 and 330 eV designs so that differences in yield are due to differences in capsule compression before ignition. The one-dimensional (1-D) calculations show that the fuel ρr reaches a maximum value when about 20–30 μm of ablator material is left behind, and this amount of ablator material provides the best trade-off between maximizing the fuel ρr, the implosion velocity, and the calculated clean yield. The results of this paper add optimized 1-D capsule designs that operate at drive temperatures of 250, 280, and 350 eV and they complement the established 300 eV CH(Br) ablator and the 330 eV Be(Cu) ablator designs.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The National Ignition Facility (NIF), currently under construction at the Lawrence Livermore National Laboratory, will provide unprecedented opportunities for the use of nuclear diagnostics in inertial confinement fusion experiments. The completed facility will provide 2 MJ of laser energy for driving targets, compared to the approximately 40 kJ that was available on Nova and the approximately 30 kJ available on Omega. Ignited NIF targets are anticipated to produce up to 1019 DT neutrons. In addition to a basic set of nuclear diagnostics based on previous experience, these higher NIF yields are expected to allow innovative nuclear diagnostic techniques to be utilized, such as neutron imaging, recoil proton techniques, and gamma-ray-based reaction history measurements. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Pinhole imaging of the neutron production in laser-driven inertial confinement fusion experiments can provide important information about the performance of various capsule designs. This requires the development of systems capable of spatial resolutions on the order of 5 μm or less for source strengths of 1015 and greater. We have initiated a program which will lead to the achievement of such a system to be employed at the National Ignition Facility (NIF) facility. Calculated neutron output distributions for various capsule designs will be presented to illustrate the information which can be gained from neutron imaging and to demonstrate the requirements for a useful system. We will describe the lines-of-sight available at NIF for neutron imaging and explain how these can be utilized to reach the required parameters for neutron imaging. We will describe initial development work to be carried out at the Omega facility and the path which will lead to systems to be implemented at NIF. Beginning this year, preliminary experiments will be aimed at achieving resolutions of 30–60 μm for direct-drive capsules with neutron outputs of about 1014. The main thrust of these experiments will be to understand issues related to the fabrication and alignment of small diameter pinhole systems as well as the problems associated with signal-to-background ratios at the image plane. Subsequent experiments at Omega will be described. These efforts will be aimed at achieving resolutions of about 10 μm. Proposed developments for new imaging systems as well as further refinement of pinhole techniques will be presented. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 10 (2002), S. 0 
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We propose that diabetic foot ulcers and diabetic mouse wounds have insufficient glutathione to maintain correct cellular redox potential. Therefore, tissue samples from the wound edge of diabetic foot ulcers, diabetic mice wounds and nondiabetic mice wounds were obtained. Levels of glutathione, cysteine, and mixed protein disulfide were determined and topical application of esterified glutathione in carboxymethylcellulose or carboxymethylcellulose alone was applied to the mice wounds. Diabetic foot ulcer mean glutathione levels were 150.6 pmol/mg in the controls and 53.4 pmol/mg at the wound edge (p 〈 0.05), while mean cysteine levels were 22.3 pmol/mg in the control and 10.5 pmol/mg at the wound edge (p 〈 0.05). The mixed protein disulfide levels were elevated in the wounds (14.6 pmol/mg), but not in the control (6.9 pmol/mg) (p 〈 0.05). The glutathione levels were lower in the diabetic mouse wounds (155 pmol/mg) than the nondiabetic mouse wounds (205 pmol/mg) (p=0.04). The diabetic mouse treated with carboxymethylcellulose alone healed slower (19.5 ± 2.2 days) than the nondiabetic mouse DM (11.5 ± 0.5 days) (p 〈 0.001). The diabetic mouse that received topical glutathione healed significantly faster (12.5 ± 0.8 days) than the carboxymethylcellulose-treated mice (19.5 ± 2.2 days) (p 〈 0.001). Glutathione levels in the diabetic mouse (26.0 pmol/mg) were lower than in the nondiabetic mouse (311.7 pmol/mg) (p 〈 0.05) after glutathione treatment. In the glutathione-treated diabetic mouse, the oxidized glutathione was higher (26.7%) than in the nondiabetic mouse (9.9%) (p=0.05). These data suggest that cellular redox dysfunction and lower glutathione levels are present in diabetic foot ulcers and diabetic mouse wounds.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Rat medullary brain segments containing primarily nucleus tractus solitarius (NTS) were used for superfusion studies of evoked transmitter release and for isotherm receptor binding assays. Isotherm binding assays with [3H]CGS-21680 on membranes prepared from NTS tissue blocks indicated a single high-affinity binding site with a KD of 5.1 ± 1.4 nM and a Bmax of 20.6 ± 2.4 fmol/mg of protein. The binding density for [3H]CGS-21680 on NTS membranes was 23 times less than comparable binding on membranes from striatal tissue. Electrically stimulated (1 min at 25 mA, 2 ms, 3 Hz) release of [3H]norepinephrine ([3H]NE) from 400-µm-thick NTS tissue slices resulted in an S2/S1 ratio of 0.96 ± 0.02. Superfusion of single tissue slices with 0.1–100 nM CGS-21680, a selective adenosine A2a receptor agonist, for 5 min before the S2 stimulus produced a significant concentration-dependent increase in the S2/S1 fractional release ratio that was maximal (31.3% increase) at 1.0 nM. However, superfusion of tissue slices with CGS-21680 over the same concentration range for 20 min before the S2 stimulus did not alter the S2/S1 ratio significantly from control release ratios. The augmented release of [3H]NE mediated by 1.0 nM CGS-21680 with a 5-min tissue exposure was abolished by 1.0 and 10 nM CGS-15943 as well as by 100 nM 8-(3-chlorostyryl)caffeine, both A2a receptor antagonists, but not by 1.0 nM 8-cyclopentyl-1,3-dipropylxanthine, the A1 receptor antagonist. Taken together, these results suggest that CGS-21680 augmented the evoked release of [3H]NE in the NTS via activation of presynaptic A2a receptors within the same concentration range as the binding affinity observed for [3H]CGS-21680. It was also apparent that this population of presynaptic adenosine A2a receptors in the NTS desensitized within 20 min because the augmenting action of CGS-21680 on evoked transmitter release was not evident at the longer interval.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ventricular Defibrillation and Cardiac Function. Introduction: The effect of implantable defibrillator shocks on cardiac hemodynamics is poorly understood. The purpose of this study was to test the hypothesis that ventricular defibrillator shocks adversely effect cardiac hemodynamics. Methods and Results: The cardiac index was determined by calculating the mitral valve inflow with transesophogeal Doppler during nonthoracotomy defibrillator implantation in 17 patients. The cardiac index was determined before, and immediately, 1 minute, 2 minutes, and 4 minutes after shocks were delivered during defibrillation energy requirement testing with 27- to 34-, 15-, 10-, 5-, 3-, or 1-J shocks. The cardiac Index was also measured at the same time points after 27- to 34-, and 1-J shocks delivered during the baseline rhythm. The cardiac index decreased from 2.30 ± 0.40 L/min per m2 before a 27- to 34-J shock during defibrillation energy requirement testing to 2.14 ± 0.45 L/min per m2 immediately afterwards (P= 0.001). This effect persisted for 〉4 minutes. An adverse hemodynamic effect of similar magnitude occurred after 15 J (P= 0.003) and 10-J shocks (P= 0.01), but dissipated after 4 minutes and within 2 minutes, respectively. There was a significant correlation between shock strength and the percent change in cardiac index (r = 0.3, P= 0.03). The cardiac index decreased 14% after a 27- to 34-J shock during the baseline rhythm (P 〈 0.0001). This effect persisted for 〈4 minutes. A 1- J shock during the baseline rhythm did not effect the cardiac index. Conclusion: Defibrillator shocks 〉9 J delivered during the baseline rhythm or during defibrillation energy requirement testing result in a 10% to 15% reduction in cardiac index, whereas smaller energy shocks do not affect cardiac hemodynamics. The duration and extent of the adverse effect are proportional to the shock strength. Shock strength, and not ventricular fibrillation, appears to be most responsible for This effect. Therefore, the detrimental hemodynamic effects of high-energy shocks may be avoided when low-energy defibrillation is used.
    Type of Medium: Electronic Resource
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