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  • 2000-2004  (1)
  • 1970-1974  (1)
  • Karyotype  (1)
  • Scalds  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Tierexperimentelle Untersuchungen zur Verbrennungskrankheit. Auswirkung lokaler Kühlung nach Verbrühung (1972)
    Springer
    Research in experimental medicine 159 (1972), S. 114-123 
    Details
    ISSN: 1433-8580
    Keywords: Scalds ; Local cooling ; Rat ; Quantity of leucocytes ; Verbrühung ; Lokale Kühlung ; Ratte ; Verhalten der Leukocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Untersuchungen an Ratten ergaben folgende Befunde: 1. Sofortige lokale Kühlung nach der Verbrühung beeinflußt bei der Ratte im untersuchten Zeitraum von 15 Tagen den Verlauf der Erkrankung gemessen am Parameter der Leukocytenzahl. 2. Die Kühlungszeit muß ausreichend lang sein. 3. Die Kühlung muß früh genug einsetzen, beim Versuchstier Ratte innerhalb 5 min nach Verbrühung. 4. Bei verspätetem Kühlungsbeginn läßt sich auch durch Verlängerung der Kühlungsdauer das Verhalten der Leukocytenzahl im Ablauf des Krankheitsgeschehens nach Verbrühung nicht beeinflussen.
    Notes: Summary Following results are obtained in experiments with rats: Immediate local cooling after scald had a significant influence on progress of “burn-disease”. Time for local cooling must be long enough, onset of local cooling early enough. It is not possible to restore the consequences of a late onset by prolongation of cooling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856038
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term survival after induction therapy with idarubicin and cytosine arabinoside for de novo acute myeloid leukemia (2000)
    Springer
    Annals of hematology 79 (2000), S. 533-542 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Cytosine arabinoside ; Idarubicin ; Induction therapy ; Karyotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We treated 153 patients with de novo acute myeloid leukemia (AML) with two induction courses of conventional-dose cytosine arabinoside (ara-C) and idarubicin (AIDA) followed by either a third course of AIDA, high-dose ara-C or bone-marrow transplantation. The complete remission (CR) rate for all patients was 63.4%, with a higher CR rate for patients with a normal (versus unfavorable) karyotype (73.2% vs 52.5%;P=0.038). The probability of overall survival (OS) was 30.7% after 5 years (26.3% after 7 years). Improved OS at 5 years could be observed for patients up to 50 years old versus patients older than 50 years of age (37.6% vs 19.9%;P=0.001) and patients with a normal (versus unfavorable) karyotype (42.9% vs 14.1%;P=0.0016). Disease-free survival (DFS) after 5 years was 33.2% for all 97 CR patients and was significantly better for patients with a normal (versus unfavorable) karyotype (44.3% vs 12.3%;P=0.003). Multivariate analysis revealed that the age for OS (P〈0.02) and the karyotype for both OS (P〈0.03) and DFS (P〈0.05) were independent prognostic factors. In conclusion, AIDA is an effective and well-tolerated induction regimen (even in elderly patients) with a 5-year survival of more than 30% when combined with ara-C-containing postremission therapy. The karyotype is the most powerful prognostic factor for predicting the outcome of patients treated with this protocol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770000193
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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