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  • 1
    Electronic Resource
    Electronic Resource
    Uric Acid in Nonhuman Primates with Special Reference to Its Renal Transport (1974)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 14 (1974), S. 355-364 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.14.040174.002035
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  • 2
    Electronic Resource
    Electronic Resource
    Role of conformational and linear epitopes in the achievement of tolerance in cow's milk allergy (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Cow's milk (CM) is one of the leading causes of food allergy in children. However, approximately 85% of milk-allergic children become clinically tolerant to CM within the first 3 years of life. The mechanisms involved in the achievement of tolerance remain unknown.Objective To study whether IgE antibodies from children with persistent cow's milk allergy (CMA) differ from children who become clinically tolerant in their ability to recognize linear and conformational epitopes of αs1- and β-casein.Methods Thirty-six milk-allergic children were included in the study: 11 of the children became clinically tolerant, and 25 had persistent CMA. Blood was obtained from all patients during the time they showed clinical reactions to milk challenge. Six non-milk-allergic children served as controls. Specific IgE antibodies against linear (denatured) as well as conformational (native) milk proteins were determined by probing dot-blots with patients' sera. In addition, selected decapeptides from αs1- and β-casein, previously found to be suggestive of persistent CMA, were synthesized on a cellulose-derivatized membrane and probed with individual sera from 10 patients who outgrew CMA and from 10 patients with persistent CMA.Results Analysis of immunodot-blots showed that, in comparison to tolerant patients, milk-allergic children with persistent symptoms had a significantly higher ratio of specific IgE antibodies to linearized than to native α- and β-casein (P 〈 0.005 and P 〈 0.02, respectively). Comparing the selected decapeptides, six of the 10 patients with persistent allergy recognized the peptide corresponding to amino acids 69–78 from αs1-casein while none of the patients who outgrew CMA had IgE binding to this epitope.Conclusion Patients with persistent milk allergy possess higher detectable levels of IgE antibodies to linear epitopes from αs1- and β-casein than children who have achieved tolerance. Specific IgE binding to particular linear epitopes in αs1-casein may be a predictive factor for persistence of CMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01218.x
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of IgE and IgG binding epitopes on β- and κ-casein in cow's milk allergic patients (2001)
    Oxford, UK : Blackwell Science, Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Cow's milk allergy (CMA) affects 2.5% of children aged less than 2 years of age. Although β- and κ-casein are considered among the major allergens responsible for CMA, no data are available on their allergenic epitopes in humans.Objective The aim of the study was to identify IgE- and IgG-binding epitopes on β- and κ-casein and to determine whether the pattern of epitope recognition is associated with the natural history of CMA.Methods Overlapping decapeptides representing the entire length of β- and κ-casein, respectively, were synthesized on a cellulose-derivatized membrane. Sera from 15 milk-allergic children, 4–18 years of age, with high levels of specific IgE antibodies to cow's milk were used to identify IgE- and IgG-binding epitopes. In addition, IgE epitopes were screened with pooled or individual sera from younger patients aged less than 3 years and who had low levels of specific serum IgE, who are likely to outgrow CMA.Results Six major and three minor IgE-binding epitopes, as well as eight major and one minor IgG binding regions, were identified on β-casein. Eight major IgE-binding epitopes, as well as two major and two minor IgG-binding epitopes, were detected on κ-casein. Three of the IgE binding regions on β-casein and six on κ-casein were recognized by the majority of patients in the older age group, but not by the younger patients.Conclusion Information regarding the immunodominant epitopes in β- and κ-casein may be important for understanding the pathophysiology and natural history of CMA. Differences in epitope recognition may be useful in identifying children who will have persistent milk hypersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01167.x
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  • 4
    Electronic Resource
    Electronic Resource
    Escapees of potentially invasive fishes from an ornamental aquaculture facility: the case of topmouth gudgeon Pseudorasbora parva (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Accidental escapees from aquacultural facilities are an ongoing problem facing scientists, conservationists, policy makers and naturalists throughout the world. The topmouth gudgeon Pseudorasbora parva, a small cyprinid native to Southeast Asia, was introduced to Romanian waters in 1960 via the aquaculture trade and has since spread throughout Europe. It first appeared in England in an ornamental fish farm near Romsey in Hampshire. The aim of the present study was to quantify the dispersal of this potentially highly invasive species from an ornamental fish farm into the wild. In order to measure the dispersal of escapees, intensive electrofishing surveys were carried out between June and September 2003 in the catchment downstream of the fish farm. The distribution of topmouth gudgeon in the catchment was found to be limited and patchy. The presence of small individuals suggests that the species has successfully established itself in the wild, but this remains to be confirmed. The results were examined in light of invasion theory principles of biological resistance and ecological fitness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2004.00559ac.x
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  • 5
    Electronic Resource
    Electronic Resource
    Die quantitative bestimmung des diquat in biologischem material (1973)
    Springer
    Archives of toxicology 30 (1973), S. 111-114 
    Details
    ISSN: 1432-0738
    Keywords: Diquat ; Reglone® ; Herbicide-Analytics ; Diquat ; Reglone® ; Herbicid-Analytik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Diquat wird durch den stark sauren Kationenaustauscher Permutit R S 40 aus dem Untersuchungsmaterial isoliert und anschlißend mit gesättigter Ammoniumchloridlösung eluiert. Die spektrophotometrische Gehaltsbestimmung erfolgt nach Reduktion der Verbindung zum grün gefärbten Radikal bei 379 nm.
    Notes: Abstract Permutit R S 40, an acid ion exchange resin, can be used to determine the herbicide Diquat. This compound is eluated by the ion exchange column with a cold saturated NH4 Cl solution. The spectrophotometric determination is carried through after reduction to a green colored radical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425928
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  • 6
    Electronic Resource
    Electronic Resource
    Klinik, Toxikologie und Therapie einer schweren Carbromalvergiftung mit letalem Ausgang (1970)
    Springer
    Archives of toxicology 26 (1970), S. 149-160 
    Details
    ISSN: 1432-0738
    Keywords: Carbromal Poisoning ; Elimination ; Forced Diuresis ; Peritoneal Dialysis ; Carbromal-Vergiftung ; Elimination ; forcierte Diurese ; Peritonealdialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbromalvergiftung mit letalem Ausgang wurde in ihrem kimischen Verlauf beschrieben. Aufgrund fortlaufend durchgeführter chemisch-toxikologischer Untersuchungen konnten die Carbromalkonzentration im Serum und die eliminierten Carbromalmengen angegeben werden. Die Effektivität der einzelnen Eliminationsverfahren, insbesondere der forcierten Diurese und Peritonealdialyse, lie\ sich anhand der Aufzeichnungen näher untersuchen. Die Todesursache wurde von pathologisch-anatomischer und von chemischtoxikologischer Sicht besprochen.
    Notes: Summary The course of a lethal carbromal (bromdiethylacetylurea) poisoning is described. Continuous quantitation of carbromal levels in the serum and the amount excreted was performed. The effectiveness of several methods of elimination of the poison, in particular forced diuresis and peritoneal dialysis, could be compared. The cause of death is discussed from a pathological-anatomical and chemical-toxicological point of view.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577801
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  • 7
    Electronic Resource
    Electronic Resource
    Klinik, Toxikologie und Therapie einer schweren Carbamazepin-Vergiftung (1971)
    Springer
    Archives of toxicology 27 (1971), S. 193-203 
    Details
    ISSN: 1432-0738
    Keywords: Carbamazepin Poisoning ; Elimination ; Forced Diuresis ; Peritoneal Dialysis ; EEG in Carbamazepin Poisoning ; Carbamazepin-Vergiftung ; Elimination ; forcierte Diurese ; Peritonealdialyse ; EEG bei Carbamazepin-Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbamazepin-Vergiftung wurde in ihrem klinischen Verlauf beschrieben. Aufgrund fortlaufend durchgeführter chemischtoxikologischer Bestimmungen von Carbamazepin in Blut, Harn, Peritonealdialysat und Magenspülflüssigkeit konnte die Effektivität der einzelnen Eliminationsverfahren näher untersucht werden.
    Notes: Abstract The course of a severe Carbamazepin poisoning is described. By performing continuous quantitation of Carbamazepin in the blood urine, peritoneal dialysate and gastric washings, the effectiveness of the various modes of elimination of the poison could be compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315042
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  • 8
    Electronic Resource
    Electronic Resource
    Klinik und Toxikologie einer mit extrakorporaler Hämodialyse behandelten Carbromal-Vergiftung mit letalem Ausgang (1971)
    Springer
    Archives of toxicology 28 (1971), S. 149-158 
    Details
    ISSN: 1432-0738
    Keywords: Carbromal Poisoning ; Anuria ; Elimination of Brominated Mono-Ureides ; Hemodialysis ; Carbromal Vergiftung ; Anurie ; Elimination bromierter Monoureide ; Hämodialyse bei Carbromal Vergiftung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine schwere Carbromal-Intoxikation mit letalem Ausgang wurde in ihrem klinischen Verlauf beschrieben. Auf Grund fortlaufend durchgeführter chemisch-toxikologischer Bestimmungen von Bromid im Serum, Magenspülflüssigkeit, Harn und Hämodialyse-Waschlösung konnte die Elimination bromierter Harnstoffderivate näher untersucht werden.
    Notes: Abstract The clinical course of a case of severe Carbromal poisoning with lethal outcome is described. Bromide was serially determined in serum, urine, gastric washings and in the bath-fluid from hemodialysis to further characterize the elimination of brominated mono-ureides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330244
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  • 9
    Electronic Resource
    Electronic Resource
    Zur Klinik der schweren Carbromal-Intoxikation (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 39-49 
    Details
    ISSN: 1432-1440
    Keywords: Severe carbromal poisoning ; clinical course ; DIC-heparinization ; haemodialysis ; Schwere Carbromal-Intoxikation ; Klink ; DIC-Heparinisierung ; Hämodialyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 27 Fällen schwerer Carbromal-Intoxikation werden die klinischen Befunde, die wichtigsten Komplikationen und Verlaufsvarianten analysiert. Daraus ergeben sich differentialtherapeutische Richtlinien: Allgemeine Intensivtherapie, Detoxikation unter besonderer Berücksichtigung der Hämodialyse, Heparinisierung im Falle einer DIC.
    Notes: Summary This report deals with 27 cases of severe carbromal poisoning. The analysis of the clinical course, its prevalent varieties and complications forms the basis of detailed therapeutic guide-lines: general supportive care, measures of detoxication including haemodialysis, and heparinization in case of DIC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468521
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