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  • 2000-2004  (2)
  • 1955-1959
  • Key words Down syndrome  (1)
  • Key words: Kidney—Renal angiomyolipoma—Computed tomography—Tuberous sclerosis—Internal structure—Doubling time.  (1)
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Material
Years
  • 2000-2004  (2)
  • 1955-1959
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Overexpression of bcl-2 in transient abnormal myelopoiesis associated with Down syndrome (2000)
    Springer
    Annals of hematology 79 (2000), S. 319-321 
    Details
    ISSN: 1432-0584
    Keywords: Key words Down syndrome ; Transient abnormal myelopoiesis ; Apoptosis ; bcl-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transient abnormal myelopoiesis (TAM) is a haematological complication found in Down syndrome. To determine the mechanisms of sustained proliferation of TAM cells, we studied the expression of apoptosis-related proteins, such as bcl-2, Fas (APO-1/CD95) and p-53, in peripheral blood cells from a new-born infant with Down syndrome and TAM. Using flow cytometry, peripheral blood mononuclear cells (PBMCs), consisting mostly of blast cells, showed marked expression of bcl-2 protein but not of Fas or p-53 products. DNA gel electrophoresis of PBMCs, cultured in the absence of serum factors, revealed no marked fragmentation. Our findings suggest that bcl-2 overexpression may be associated with prolonged cell survival of TAM cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002779900138
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Renal angiomyolipoma: evolutional changes of its internal structure on CT (2000)
    Springer
    Abdominal imaging 25 (2000), S. 651-654 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Kidney—Renal angiomyolipoma—Computed tomography—Tuberous sclerosis—Internal structure—Doubling time.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: We evaluated interval changes of the internal structure of renal angiomyolipomas in relation to the doubling time on computed tomography (CT). Methods: A retrospective review of 42 renal angiomyolipomas in 10 patients who had been followed up for more than 5 months with CT was performed. The doubling time of each tumor was estimated. We classified the internal structures of the tumors into five types, based on the fat component percentage. We compared changes between initial and follow-up CT, and the relationship with the doubling time was evaluated. Results: The fat component increased more than the soft tissue component in 15 tumors (36%). The soft tissue component increased more than the fat component in only one tumor, in which an intratumoral hemorrhage occurred during the follow-up period. Twenty-six tumors (62%) showed no change. Most tumors with relatively long doubling times did not show a change in their internal structures. Conclusion: The growth of renal angiomyolipoma is due mainly to an increase in its fat component. An increase in the soft tissue component suggests the development of an intratumoral hemorrhage. RID="" ID="" 〈E5〉Correspondence to:〈/E5〉 S. Yamamoto
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002610000051
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    Paper (German National Licenses)
    Fulltext
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