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  • 2000-2004  (2)
  • Micron-sized, monodispersed particle  (1)
  • cyclophosphamide  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Dose-escalation study of CHOP with or without prophylactic G-CSF in aggressive non-Hodgkin's lymphoma (2000)
    Springer
    Annals of oncology 11 (2000), S. 1241-1247 
    Details
    ISSN: 1569-8041
    Keywords: cyclophosphamide ; dose intensity ; doxorubicin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:CHOP is accepted as the gold standard for first linechemotherapy of aggressive non-Hodgkin's lymphoma (NHL). A dose-escalationstudy of CHOP was conducted to determine the maximal tolerated dose (MTD) andtoxicity profile of CHOP at three-week intervals with or without prophylacticrecombinant human granulocyte colony-stimulating factor (rHuG-CSF) in patientswith aggressive NHL. Patients and methods:The doses of drugs were escalated from 50mg/m2 to 70 mg/m2 for doxorubicin and from 750mg/m2 to 2250 mg/m2 for cyclophosphamide, withconventional doses of vincristine and oral prednisolone. After the MTD wasdetermined without rHuG-CSF, dose escalation was conducted with prophylacticrHuG-CSF. Results:Thirty-three patients with NHL were enrolled into thestudy. The MTD without prophylactic rHuG-CSF was 70 mg/m2 ofdoxorubicin and 1250 mg/m2 of cyclophosphamide, with neutropeniaas a dose-limiting toxicity. The MTD with prophylactic rHuG-CSF was 70mg/m2 of doxorubicin and 2250 mg/m2 of cyclophosphamide.The overall response rate was 100% (76% complete response and24% partial response). Progression-free survival and overall survivalat five years were 45% and 66%, respectively. Conclusions:Significant dose escalation of doxorubicin andcyclophosphamide was feasible with prophylactic rHuG-CSF. The efficacy ofdose-escalated CHOP should be compared with that of standard CHOP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008361513544
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of micron-sized, monodispersed, anomalous polymer particles by utilizing the solvent-absorbing/releasing method (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 919-926 
    Details
    ISSN: 1435-1536
    Keywords: Key words Anomalous shape ; Micron-sized, monodispersed particle ; Solvent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  About 2-μm-sized polystyrene (PS) particles having uneven surfaces were prepared by a posttreatment in which toluene-swollen PS particles were thrown into a methanol bath to release toluene therefrom rapidly. The posttreatment was named the “solvent-absorbing/releasing method”. The PS particle had large dents at the surface. The size of the dents was changed by the conditions of the posttreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960000339
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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