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  • 1
    Electronic Resource
    Electronic Resource
    Tolcapone increases maximum concentration of levodopa (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 113-119 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Tolcapone, levodopa, pharmacokinetics.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. No significant increase of the maximum concentration (Cmax) of levodopa after addition of catechol-O-methyltransferase inhibitor tolcapone occurred in previous pharmacokinetic studies predominantly on healthy volunteers. We compared pharmacokinetics of levodopa in plasma before and after addition of tolcapone in 13 treated parkinsonian subjects under standardized conditions. We found a significant increase of Cmax of levodopa after the addition of tolcapone. This may represent one cause for the occurrence of dyskinesia previously early in the course of treatment with tolcapone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050010
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Glutathione S-transferase polymorphism in Parkinson's disease (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 331-334 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinsons disease, glutathione S-transferase, GSTM1, GSTT1.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Glutathione S-transferases (GSTs) are involved in the detoxification of endogenous or exogenous toxins, which may play a role in the pathogenesis of Parkinson's disease. We genotyped the Glutathione-S-Transferase isoenzymes GSTM1 and GSTT1 by polymerase chain reaction in order to evaluate different gene polymorphisms of these isoenzymes in 149 parkinsonian and 99 control subjects. No differences appeared between both groups regarding the frequencies of the homozygous deletion of GSTM1 (odds ratio 1.021; 95% Cl [0.613; 1.699], p 〈 0.521 Fisher's exact test) and GSTT1 (odds ratio 1.514; 95% Cl [0.811; 2.824], p 〈 0.127). Age of onset of PD did notcorrelate to GSTM1 and GSTT1 polymorphisms. These results do not support the hypothesis of a possible impact of GSTM1 and GSTT1 detoxification activities in the pathogenesis of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050027
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The activity of Catechol-O-Methyltransferase in parkinsonian patients with "on-off fluctuations" (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 105-111 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: COMT, Parkinson disease, motor fluctuations.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Motor fluctuations complicate therapy in Parkinson's disease (PD). The mechanisms responsible for motor fluctuations such as the on-off type, are poorly understood. Differences of activity of various enzymes, such as Catechol-O-Methyltransferase (COMT, E.C.2.1.1.6.) may influence the appearance of motor fluctuations and the quantity of metabolic products of levodopa. Aim of this study was to compare erythrocyte COMT-activity in Parkinsonian patients without and with motor fluctuations from the on-off type. No significant differences in COMT-activity appeared in both groups. We conclude that activity differences in COMT-activity do not contribute to the appearance of motor fluctuations in Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050009
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Motor performance: normative data, age dependence and handedness (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 73-85 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Motor performance, normative data, age dependence, handedness.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Quantitative, apparatus-based assessment of motor performance is a useful tool when addressing questions of therapy evaluation, quality control and early detection of movement disorders. Until now, few such methods have been sufficiently standardised to allow their routine employment in the clinic. Before assessing the impaired performance of patients, the first stage of standardisation is the determination of criteria of normal performance in healthy subjects. We have standardised a multidimensional test battery for motor performance of the upper extremities (Schoppe's "motorische Leistungs-Serie" = MLS). On the basis of the performance of 80 healthy controls, normative algorithms which allow correction of performance with reference to age were calculated. Further, our investigation provided information concerning the complexity of normal motor performance and the question of laterality (handedness). Standardised apparatus-based quantification of performance promises to be a valuable supplement to rating scales in the evaluation of patient motor skills, particularly in the early stages of their illness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050006
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic analysis of immunomodulating factors in sporadic Parkinson's disease (2000)
    Springer
    Journal of neural transmission 107 (2000), S. 553-562 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Parkinson's disease, genetics, immunomodulation, tumor necrosis factor alpha.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, pc = 0.13, χ2 = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1−609 and TNFRI+36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, pc = 0.048, χ2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020070078
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    Paper (German National Licenses)
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