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  • 1995-1999  (8)
  • 1990-1994  (10)
  • 1975-1979  (5)
  • Organic Chemistry  (17)
  • Amphetamine  (4)
  • Embolisation  (2)
  • 1
    ISSN: 1432-1920
    Keywords: Key words Arterial aneurysm ; Guglielmi detachable coil ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report 28 patients with nonsurgical intracranial aneurysms referred by neurosurgeons for endovascular treatment using platinum detachable coils (GDC, Target Therapeutics, Fremont, Calif., USA). Because of unfavourable anatomical features or failed hyperselective catheterisation, 4 patients were not treated. In the other 24 patients (26 aneurysms) embolisation was successful. No manufacturing defect was detected in the coils used. Complete occlusion of the sac was obtained in 22 of the 26 aneurysms (85 %) regardless of their size. The glasgow outcome score was good on discharge in 20 of the 24 patients (83 %). The Karnovski score at 3 months after embolisation revealed that 20 patients (83 %) lead a normal life, with minor neurological signs. Morbidity related directly to treatment occurred in 2 cases (8 %): a superior hemianopia due to mass effect on the optic nerve from a carotid-ophthalmic aneurysm, and hemiparesis due to an embolus. Five transient deficits lasting hours to a few days were related to proven or suspected emboli. No death occurred. Anatomical, technical and clinical data are reported; the mean cost of materials (catheters and coils) per patient and aneurysm was FF 13 500. The mean hospitalisation time was 6.5 days in the neurosurgical department with 2.8 days of intensive care.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Arterial aneurysm ; Guglielmi detachable coil ; Embolisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report 28 patients with nonsurgical intracranial aneurysms referred by neurosurgeons for endovascular treatment using platinum detachable coils (GDC, Target Therapeutics, Fremont, Calif., USA). Because of unfavourable anatomical features or failed hyperselective catheterisation, 4 patients were not treated. In the other 24 patients (26 aneurysms) embolisation was successful. No manufacturing defect was detected in the coils used. Complete occlusion of the sac was obtained in 22 of the 26 aneurysms (85 %) regardless of their size. The glasgow outcome score was good on discharge in 20 of the 24 patients (83 %). The Karnovski score at 3 months after embolisation revealed that 20 patients (83 %) lead a normal life, with minor neurological signs. Morbidity related directly to treatment occurred in 2 cases (8 %): a superior hemianopia due to mass effect on the optic nerve from a carotid-ophthalmic aneurysm, and hemiparesis due to an embolus. Five transient deficits lasting hours to a few days were related to proven or suspected emboli. No death occurred. Anatomical, technical and clinical data are reported; the mean cost of materials (catheters and coils) per patient and aneurysm was FF 13 500. The mean hospitalisation time was 6.5 days in the neurosurgical department with 2.8 days of intensive care.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 102 (1990), S. 221-226 
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Norfenfluramine ; Amphetamine ; Pentobarbital ; Session-to-criterion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 42 (1975), S. 185-193 
    ISSN: 1432-2072
    Keywords: Amphetamine ; Dopamine ; Haloperidol ; State-Dependent Behavior ; Apomorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-Β-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas α- and Β-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 101 (1990), S. 126-131 
    ISSN: 1432-2072
    Keywords: Cathinone ; Amphetamine ; Cathine ; Drug discrimination ; Dopamine ; CGS 10746B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kgd-amphetamine or 0.8 mg/kgl-cathinone to generalize to 2.4–6.0 mg/kg of the active cathinone metabolited-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n=6) trained with cathinone (ED50=3.03 mg/kg) and in rats (n=8) trained with amphetamine (ED50=2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2072
    Keywords: Aggression ; Morphine ; Naloxone ; Apomorphine ; Amphetamine ; Narcotic Withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aggression, which is normally seen during withdrawal from narcotics, could not be produced in morphine-dependent rats by the administration of naloxone at doses which cause other signs of withdrawal. Apomorphine injected instead of naloxone was capable of producing aggression, without other withdrawal signs. Naturally occurring aggression (72-hr withdrawal) was enhanced by apomorphine and unaffected by naloxone.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 320 (1978), S. 877-877 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 336 (1994), S. 283-284 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 164-165 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 164-164 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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