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Structural and transport properties of biaxially aligned YBa2Cu3O7−x films on polycrystalline Ni-based alloy with ion-beam-modified buffer layers (1993)

Iijima, Y. ; Onabe, K. ; Futaki, N. ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Journal of Applied Physics 74 (1993), S. 1905-1911

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ISSN: 1089-7550

Source: AIP Digital Archive

Topics: Physics

Notes: Biaxially aligned YBa2Cu3O7−x (YBCO) thin films were produced on polycrystalline Ni-based alloy, by using biaxial yttria-stabilized-zirconia (YSZ) intermediate layers formed by off-normal ion-beam-assisted deposition. Most explicit in-plane alignment was obtained when the YSZ layer formed with the beam-incident angle of 55° from substrate normal. Jc-B characteristics and angular dependence of Jc on the magnetic field were measured. 5.0×105 and 5.5×104 A/cm2 were obtained at 77 K with 0 and 8 T, respectively. The distribution of misorientation angles of in-plane a and b axes between YBCO grains was evaluated by both x-ray pole figure measurement and planar observations of transmission electron microscopy. 50% of the grains had the misorientation angles restricted within ±5°. From the image of dislocations, the elastic strains at grain boundaries were estimated to be relaxed with lower misorientation angle. The high-Jc properties are understood to be obtained by the current paths through low-angle grain boundaries.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.354801

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Selective inhibition of cyclooxygenase-2 by NS-398 in endotoxin shock rats in vivo (1997)

Futaki, N. ; Takahashi, S. ; Kitagawa, T. ; [et al.]

Springer

Inflammation research 46 (1997), S. 496-502

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ISSN: 1420-908X

Keywords: Key words: Cyclooxygenase-1 — Cyclooxygenase-2 — NSAIDs — Selective inhibition — NS-398

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract. Objective and Design: The role of cyclooxygenase (COX)-2 was examined using a rat endotoxin shock model and the potency and selectivity of NS-398, a COX-2 selective inhibitor in vitro, for COX-2 activity was examined in vivo.¶Material: Male Wistar rats (weighing 140–180 g) were used.¶Methods: Lipopolysaccharide (LPS, 1 mg/kg, i.v.) was administered to rats (LPS-treated rats) and expression of COX-1 mRNA and COX-2 mRNA in the aorta and peripheral blood leukocytes was examined by RT-PCR. COX activity was assessed by measuring the plasma 6-keto prostaglandin (PG) F1 α, PGE2 and thromboxane (TX) B2 30 s after administration of arachidonic acid (AA, 3 mg/kg, i.v.). NS-398 (0.3–100 mg/kg, p.o.) or indomethacin (0.3–3 mg/kg, p.o.) was administered 1 h before the AA injection.¶Results: COX-2 mRNA was detectable in the aorta and peripheral blood leukocytes at least from 3 to 9 h after the LPS injection but not in non-LPS-treated rats. Plasma 6-keto PGF1 α, PGE2 and TXB2 levels after AA injection into LPS-treated rats were significantly enhanced compared to findings in non-LPS-treated rats. NS-398 showed significant inhibition of the increase in PGs in LPS-treated rats, the ED50 values being 0.35 mg/kg for 6-keto PGF1 α, 1.5 mg/kg for PGE2 and 〈 0.3 mg/kg for TXB2. NS-398 even at 100 mg/kg did not significantly suppress the increased PGs levels in non-LPS-treated rats. In contrast, indomethacin significantly inhibited plasma PGs levels after AA injection into LPS-treated rats and non-LPS-treated rats. The ED50 values in LPS-treated rats, determined by 6-keto PGF1 α, PGE2 and TXB2 production, were 1.0, 1.3 and 2.3 mg/kg and those in non-LPS-treated rats were 0.42, 0.24 and 0.93 mg/kg, respectively.¶Conclusions: In a rat endotoxin shock model, expression of COX-2 plays a role in an increase in COX activity. NS-398 showed preferential inhibitory effects on COX-2 activity in vivo. This approach is useful to directly analyze the inhibitory activity of NSAIDs for COX-1 and COX-2 in vivo.