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  • 1995-1999  (3)
  • 1985-1989  (1)
  • 1980-1984
  • clozapine  (2)
  • Behavioral sensitization  (1)
  • ERF (EREBP)  (1)
Source
Material
Years
  • 1995-1999  (3)
  • 1985-1989  (1)
  • 1980-1984
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 227-240 
    Details
    ISSN: 1435-1463
    Keywords: Neuroleptics ; dopamine ; prolactin ; hypothalamus ; clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two atypical neuroleptic agents, clozapine and fluperlapine, produced rapid elevations in plasma PRL concentrations that were similar in magnitude to those produced by haloperidol. However, the PRL response to clozapine or fluperlapine was of much shorter duration than that elicited by haloperidol. Clozapine, but neither fluperlapine nor haloperidol, produced a rapid increase in the activity of tuberoinfundibular dopamine (TIDA) neurons, as evidenced by an enhanced accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after the inhibition of DOPA decarboxylase. The clozapine-induced increase in DOPA accumulation was evident within 30 minutes after its administration and persisted for at least 4 hours. The clozapine-induced increase in the activity of TIDA neurons may account, in part, for the abbreviated PRL response to this neuroleptic. In addition, ability to produce a short-lived increase in PRL secretion in the rat appears to be common to the atypicl neuroleptic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02098500
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Constitutive expression of the neutral PR-5 (OLP, PR-5d) gene in roots and cultured cells of tobacco is mediated by ethylene-responsive cis-element AGCCGCC sequences (1998)
    Springer
    Plant cell reports 18 (1998), S. 173-179 
    Details
    ISSN: 1432-203X
    Keywords: Key words Callus ; ERF (EREBP) ; Osmotin-like protein ; Root ; Tobacco
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The constitutive accumulation of tobacco neutral PR-5 (osmotin-like protein; OLP, PR-5d) in roots and cultured cells was studied in transgenic tobacco plants harboring the OLP promoter::GUS gene. This construct showed strong β-glucuronidase expression in vascular tissues and cortex of roots as well as in cultured cells. Analysis using a mutated promoter showed that ethylene-responsive elements (AGCCGCC) were necessary for constitutive expression in roots and cultured cells. An electrophoretic mobility shift assay indicated that ERF3 (EREBP3), an ethylene-responsive-element-binding factor that was reported to be expressed in roots and in cultured cells as well as in ethephon-treated leaves, could bind to the AGCCGCC sequences of the OLP gene. These findings suggest that AGCCGCC sequences and ERFs mediate the constitutive expression of the OLP gene in roots and cultured cells of tobacco.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050552
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Scopolamine prevents augmentation of stereotypy induced by chronic methamphetamine treatment (1995)
    Springer
    Psychopharmacology 121 (1995), S. 158-163 
    Details
    ISSN: 1432-2072
    Keywords: Methamphetamine ; Behavioral sensitization ; Scopolamine ; Acetylcholine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether scopolamine, a muscarinic cholinergic antagonist, would also block augmentation of stereotypy induced by chronic methamphetamine (MA) treatment. Rats treated with MA (2.5 mg/kg, SC) for 10 days indicated significantly enhanced stereotyped behavior when tested with MA (2.5 mg/kg) after a 7-to 8- day withdrawal. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the augmentation of stereotypy. Rats treated with scopolamine alone showed no difference in MA-induced stereotypy compared to those treated with saline. Scopolamine methylbromide, a derivative of scopolamine that does not easily cross the blood-brain barrier, had no effect on the augmentation of stereotypy. These results suggest that stimulation of central muscarinic cholinergic receptors plays a role in the development of sensitization to the stereotypy stimulating effect of methamphetamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245625
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Long-term treatment with haloperidol or clozapine does not affect dopamine D4 receptors in rat frontal cortex (1995)
    Springer
    Journal of neural transmission 101 (1995), S. 231-235 
    Details
    ISSN: 1435-1463
    Keywords: [3H]clozapine ; dopamine D4 receptor ; frontal cortex ; haloperidol ; clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the effects of long-term treatment with haloperidol and clozapine on dopamine D4 receptors in rat frontal cortex. Dopamine D4 receptor binding sites were indirectly determined from the displacement experiments of [3H]clozapine binding using nemonapride. Three-weeks administration of haloperidol (0.5mg/kg) or clozapine (10mg/kg) did not significantly affect the D4 receptors in the frontal cortex. The density of D2 receptors, determined by [3H]spiperone binding to striatum, was increased by long-term treatment with haloperidol, but it was not significantly changed by that with clozapine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01271560
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    Paper (German National Licenses)
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