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  • 1995-1999  (3)
  • 1985-1989
  • subarachnoid haemorrhage  (2)
  • Keywords: Acute subarachnoid haemorrhage; sympathetic nerve activity; intracranial pressure; cerebral blood flow; α-blockers.  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Anti-phospholipid antibodies and cerebral vasospasm following subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 191-197 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral vasospasm ; subarachnoid haemorrhage ; lupus anticoagulant ; anti-cardiolipin antibodies ; platelet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Delayed ischaemic deficits due to cerebral vasospasm contribute to the high morbidity and mortality rates associated with subarachnoid haemorrhage. We evaluated the usefulness of measuring anti-phospholipid antibodies (aPLs) for prediction of the occurrence of symptomatic vasospasm and the outcome after subarachnoid haemorrhage. 32 consecutive patients with subarachnoid haemorrhage due to ruptured cerebral aneurysms were studied. They were admitted and operated on within 72 hours after the onset of subarachnoid haemorrhage. aPLs such as lupus anticoagulants, anti-cardiolipin IgG and anti-cardiolipin IgM were measured repeatedly after admission. Furthermore, platelet count, platelet aggregability and plasma platelet factor 4 were also measured. Eleven among the 32 patients (34.4%) showed positive in the examination for aPLs. Although aPLs could not predict symptomatic vasospasm, once symptomatic vasospasm occurred, patients with aPLs frequently demonstrated cerebral infarction and there-fore their outcome was worse. aPLs were associated with a severe initial clinical grade and SAH grade on CT scan. Therefore it may explain the association of aPLs with worse outcome. aPLs were detected between 1 and 7 days. Four of 6 patients (67%) with aPLs became negative between 7 and 13 days after subarachnoid haemorrhage. The mechanism of transient aPLs is unclear but it is more likely to occur in the severer grade patients. The reduction in platelet count, the increased platelet aggregability, and the increased plasma platelet factor 4 concentration were also observed in aPLs-positive patients with symptomatic vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187767
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The use of computed tomography in the prediction of delayed cerebral infarction following acute aneurysm surgery for subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 9-13 
    Details
    ISSN: 0942-0940
    Keywords: Acute aneurysmal surgery ; cerebral infarction ; cerebral vasospasm ; computed tomography ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to predict the occurrence of cerebral infarction after aneurysmal surgery in patients with subarachnoid haemorrhage, we measured the amount of subarachnoid blood on initial and on post-operative computed tomograms. We used a reliable grading method to estimate the amount of blood on computed tomograms in 24 patients with infarction due to vasospasm and 45 patients without cerebral infarction, all of whom underwent aneurysmal surgery within 48 hours after the ictus. The total amount of subarachnoid blood on admission and on the day after operation was more in the cerebral infarction group than in the non-infarction group. The clearance rate of subarachnoid blood by surgery was lower in patients with cerebral infarction than in patients without infarction and the predominant site of subarachnoid blood corresponded with the site of the infarct. Of 24 patients with cerebral infarction, 22 (92%) belonged to the group whose initial total blood score was more than 10 on admission and whose clearance rate by surgery was less than 50%. Therefore, we propose this range to be an indication for the occurrence of cerebral infarction in postoperative patients due to cerebral vasospasm. The presence of intracerebral haematoma and the amount of ventricular blood and their clearance by surgery were also estimated for the prediction of delayed cerebral infarction after aneurysmal surgery. However, they had no relation to the occurrence of cerebral infarction due to vasospasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404841
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Related Changes in Sympathetic Activity, Cerebral Blood Flow and Intracranial Pressure, and Effect of an α-Blocker in Experimental Subarachnoid Haemorrhage (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 415-424 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Acute subarachnoid haemorrhage; sympathetic nerve activity; intracranial pressure; cerebral blood flow; α-blockers.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  We investigated the changes in sympathetic nerve activity (SNA) and cerebral blood flow (CBF) with or without increase in intracranial pressure (ICP) in the acute stage of experimental subarachnoid haemorrhage (SAH). ICP was increased or controlled by rapid or slow injection of blood and saline, and the effect of an α-blocker, phentolamine, was also investigated in each condition. Following marked increase in ICP induced by rapid injection of blood or saline, increase in intracranial and general SNA and decrease in CBF were observed. Both changes were significantly decreased in magnitude by prior administration of phentolamine. When increase in ICP was not induced, by slow injection of blood, both SNA and CBF decreased, and these changes were alleviated by phentolamine. However, when increase in ICP was not induced by saline, neither SNA nor CBF significantly changed. These findings suggest that marked increase in ICP is the primary cause of the pathological changes occurring immediately after SAH, and that the decrease in CBF in mild SAH without increase in ICP is caused by blood itself. Administration of an α-blocker may be effective in improving the abnormal sympathetic nervous system induced by marked increase in ICP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050318
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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