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  • 1
    ISSN: 1432-0584
    Keywords: Amyloidosis ; Monoclonal protein ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 55 amyloidoses, the detection of a monoclonal protein (MP) led to the selection of 15 primary and 3 myeloma-associated types of amyloidosis. Therefore the presence of a MP gives evidence for an immunocytic amyloidosis. The λ-light-chain nature of MP and the abundant production of free light-chains are two of the factors predisposing to the production of amyloid deposits (AL) in the course of immunocyte dyscrasias.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 90 (1996), S. 139-159 
    ISSN: 1573-2878
    Keywords: Nonlinear parameter estimation ; associative memory ; adaptive training ; linear associative memory matrix ; weighted cost function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The method of linear associative memory (LAM), a notion from the field of artificial neural nets, has been applied recently in nonlinear parameter estimation. In the LAM method, a model response, nonlinear with respect to the parameters, is approximated linearly by a matrix, which maps inversely from a response vector to a parameter vector. This matrix is determined from a set of initial training parameter vectors and their response vectors, and can be update recursively and adaptively with a pair of newly generated parameter response vectors. The LAM advantage is that it can yield a good estimation of the true parameters from a given observed response, even if the initial training parameter vectors are far from the true values. In this paper, we present a weighted linear associative memory (WLAM) for nonlinear parameter estimation. WLAM improves LAM by taking into account an observed response vector oriented weighting. The basic idea is to weight each pair of parameter response vectors in the cost function such that, if a response vector is closer to the observed one, then this pair plays a more important role in the cost function. This weighting algorithm improves significantly the accuracy of parameter estimation as compared to a LAM without weighting. In addition, we are able to construct the associative memory matrix recursively, while taking the weighting procedure into account, and simultaneously update the ridge parameter α of the cost function further improving the efficiency of the WLAM estimation. These features enable WLAM to be a powerful tool for nonlinear parameter simulation.
    Type of Medium: Electronic Resource
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