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  • 1
    Electronic Resource
    Electronic Resource
    Reno-kardiale Wechselwirkungen bei Niereninsuffizienz (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1043-1050 
    Details
    ISSN: 1432-1440
    Keywords: Kidney disease ; Uremia ; Hypertension ; Cardiovascular system ; Cardiac glycosides ; Nierenerkrankung ; Urämie ; Hypertonie ; Herzgefäßsystem ; Herzglykoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Häufung kardialer Komplikationen bei terminaler Niereninsuffizienz ist nicht nur Folge einer chronischen Druckbelastung des linken Ventrikels, obwohl sich der Anteil der Hypertoniker mit fortschreitender renoparenchymatöser Erkrankung von 53 auf 81% erhöht. Andere Faktoren wie Anämie, Hyperparathyreoidismus, autonome Neuropathie und Retention von Elektrolyten, Stoffwechselprodukten oder Toxinen können das Herz schädigen. Ob die Urämie selbst eine Kardiomyopathie verursacht, ist noch nicht geklärt. Befunde über eine verminderte Ca++-Aufnahme während β-adrenerger Stimulation und über eine verminderte Reaktion der Membran-(Na+, K+)-ATPase auf Digitalis lassen eine tiefgreifende Änderung des myokardialen Membranstoffwechsels vermuten. Eine Retention von “endogenem Digitalis” bei Niereninsuffizienz könnte eine Reihe widersprüchlicher Befunde erklären.
    Notes: Summary The high incidence of cardiac complications in endstage renal failure is not only related to the chronic pressure load of the left ventricle, although the proportion of patients with elevated blood pressure increases from 53 to 81% as reno-parenchymal disease progresses. Other factors as anemia, hyperparathyroidism, autonomic neuropathy and retention of electrolytes, metabolic products or toxins may cause damage to the heart. It is a matter of discussion whether uremia itself causes cardiomyopathy. Findings of a reduced Ca++-uptake during β-adrenergic stimulation and a reduced reaction of (Na+, K+)-ATPase to digitalis suggest a basic change of myocardial membrane metabolism. Retention of an “endogenous digitalis” could help to explain some contradictory results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476875
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cardiac phase-synchronized myocardial thallium-201 single-photon emission tomography using list mode data acquisition and iterative tomographic reconstruction (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 276-280 
    Details
    ISSN: 1619-7089
    Keywords: Myocardium ; Coronary artery disease ; Myocardial contraction ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to determine whether data acquisition in the list mode and iterative tomographic reconstruction would render feasible cardiac phase-synchronized thallium-201 single-photon emission tomography (SPET) of the myocardium under routine conditions without modifications in tracer dose, acquisition time, or number of steps of the a gamma camera. Seventy non-selected patients underwent201Tl SPET imaging according to a routine protocol (74 MBq/2 mCi201Tl, 180° rotation of the gamma camera, 32 steps, 30 min). Gamma camera data, ECG, and a time signal were recorded in list mode. The cardiac cycle was divided into eight phases, the end-diastolic phase encompassing the QRS complex, and the end-systolic phase the T wave. Both phase- and non-phase-synchronized tomograms based on the same list mode data were reconstructed iteratively. Phase-synchronized and non-synchronized images were compared. Patients were divided into two groups depending on whether or not coronary artery disease had been definitely diagnosed prior to SPET imaging. The numbers of patients in both groups demonstrating defects visible on the phase-synchronized but not on the non-synchronized images were compared. It was found that both postexercise and redistribution phase tomograms were suited for interpretation. The changes from end-diastolic to end-systolic images allowed a comparative assessment of regional wall motility and tracer uptake. End-diastolic tomograms provided the best definition of defects. Additional defects not apparent on non-synchronized images were visible in 40 patients, six of whom did not show any defect on the non-synchronized images. Of 42 patients in whom coronary artery disease had been definitely diagnosed, 19 had additional defects not visible on the non-synchronized images, in comparison to 21 of 28 in whom coronary artery disease was suspected (P〈0.02; χ2). It is concluded that cardiac phase-synchronized201Tl SPET of the myocardium was made feasible by list mode data acquisition and iterative reconstruction. The additional findings on the phase-synchronized tomograms, not visible on the non-synchronized ones, represented genuine defects. Cardiac phase-synchronized201Tl SPET is advantageous in allowing simultaneous assessment of regional wall motion and tracer uptake, and in visualizing smaller defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728763
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cardiac phase-synchronized myocardial thallium-201 single-photon emission tomography using list mode data acquisition and iterative tomographic reconstruction (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 276-280 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Myocardium ; Coronary artery disease ; Myocardial contraction ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to determine whether data acquisition in the list mode and iterative tomographic reconstruction would render feasible cardiac phase-synchronized thallium-201 single-photon emission tomography (SPET) of the myocardium under routine conditions without modifications in tracer dose, acquisition time, or number of steps of the a gamma camera. Seventy non-selected patients underwent 201Tl SPET imaging according to a routine protocol (74 MBq/2 mCi 201Tl, 180° rotation of the gamma camera, 32 steps, 30 min). Gamma camera data, ECG, and a time signal were recorded in list mode. The cardiac cycle was divided into eight phases, the end-diastolic phase encompassing the QRS complex, and the end-systolic phase the T wave. Both phase- and non-phase-synchronized tomograms based on the same list mode data were reconstructed iteratively. Phase-synchronized and non-synchronized images were compared. Patients were divided into two groups depending on whether or not coronary artery disease had been definitely diagnosed prior to SPET imaging. The numbers of patients in both groups demonstrating defects visible on the phase-synchronized but not on the non-synchronized images were compared. It was found that both postexercise and redistribution phase tomograms were suited for interpretation. The changes from end-diastolic to end-systolic images allowed a comparative assessment of regional wall motility and tracer uptake. End-diastolic tomograms provided the best definition of defects. Additional defects not apparent on non-synchronized images were visible in 40 patients, six of whom did not show any defect on the non-synchronized images. Of 42 patients in whom coronary artery disease had been definitely diagnosed, 19 had additional defects not visible on the non-synchronized images, in comparison to 21 of 28 in whom coronary artery disease was suspected (P〈0.02; χ2). It is concluded that cardiac phase-synchronized 201Tl SPET of the myocardium was made feasible by list mode data acquisition and iterative reconstruction. The additional findings on the phase-synchronized tomograms, not visible on the non-synchronized ones, represented genuine defects. Cardiac phase-synchronized 201Tl SPET is advantageous in allowing simultaneous assessment of regional wall motion and tracer uptake, and in visualizing smaller defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728763
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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