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  • 1
    Electronic Resource
    Electronic Resource
    Schlußwort zur vorstehenden Diskussionsbemerkung (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 556-556 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468731
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intensive short-term chemotherapy in patients with advanced breast cancer (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 317-323 
    Details
    ISSN: 1432-1440
    Keywords: Breast cancer ; Complete remission ; Remission maintenance ; Intensive short-term chemotherapy ; Medroxyprogesterone acetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Aiming at a high complete remission rate with an intensive induction regimen, 27 patients with advanced breast cancer were given three cycles of VAC chemotherapy consisting of vinde-sine 3 mg/m2 i.v. on days 1 and 12, adriamycin 40 mg/m2 i.v. on days 1 and 12, and cyclophosphamide 200 mg/m2 p.o. on days 3–6 and 14–17 together with medroxyprogesterone acetate (MPA) 1,500 mg p.o. daily during the induction phase and 1,000 mg p.o. thereafter until relapse. These VAC double cycles were repeated twice with 3-weekly intervals for a total induction period of 15 weeks. In responders, including no change, the chemotherapy was discontinued thereafter, and the patients were observed until relapse with a maintenance therapy of MPA 1,000 mg p.o. daily. A complete remission (CR) was achieved in 8 (29.6%) and a partial remission (PR) in 13 (48.2%) of the 27 patients (CR + PR 77.8%). A no change (NC) status was found in 6 patients (22.2%). There were no nonresponders. The median duration of the CR was 20 (5–42) months with two patients still in CR at 33 and 36 months, of the PR 8.3 (4–13.5) months, and of the NC 6.7 (2–13) months. The treatment was tolerated without life-threatening toxicity or interval prolongation by all patients. No dose-limiting cardiac toxicity was observed in these patients regularly controlled by left ventricular ejection fraction (LVEF). The high response rate of this intensive induction regimen warrants further investigation. Complete remission was achieved only in patients without previous chemotherapy, with marked tumor regression after the first chemotherapy cycle and when there was no extensive bone involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745385
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  • 3
    Electronic Resource
    Electronic Resource
    Osteoporose-Diagnostik mit einem125J-Profilscanner bei renaler Osteopathie (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 767-768 
    Details
    ISSN: 1432-1440
    Keywords: Osteoprosis ; Transmission profile scanning ; Renal insufficiency ; Chronic ; Osteoporose ; Profilscanner ; chronische Niereninsuffizienz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die quantitative Bestimmung der Absorption einer125J-Strahlenquelle durch die Mittelphalanx eines Fingers soll die frühzeitige Erkennung und Verlaufskontrolle von Skeletkalksalzminderungen gestatten. Der vorläufige Normalwertbereich von 86 Probanden deckt sich mit den Angaben in der Literatur, während die Reproduzierbarkeit der Einzel- als auch der wiederholten Messungen deutlich abweicht. Die radiologische Osteoporose bei chronisch niereninsuffizienten Patienten konnte nur in 33% durch die Messung der Absorption am Finger bestätigt werden.
    Notes: Summary Quantitative transmission profile scanning of the middle phalanx of the left forefinger was performed using the method of Börneret al. Normal ranges, different for sex and age, were established by the investigation of 86 patients showing no evidence of bone disease. The evaluation of this method's reproducibility in 5 normal subjects gave the following results: S. D. at five different days 7–35% S. D. at five continuous determinations 3.5–9.0%. Of 47 patients with severe chronic renal insufficiency, 33 showed signs of osteoporosis evidenced by radiological examination. Only in 13 of them were the absorption coefficients significantly decreased. Of the 14 patients without radiological evidence of osteoporosis 7 had normal and 7 other decreased values. It is concluded that the reproducibility of the method is not sufficient for follow-up studies and that the forefinger might not be representative for bone decalcification caused by chronic renal insufficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468283
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  • 4
    Electronic Resource
    Electronic Resource
    Reno-kardiale Wechselwirkungen bei Niereninsuffizienz (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1043-1050 
    Details
    ISSN: 1432-1440
    Keywords: Kidney disease ; Uremia ; Hypertension ; Cardiovascular system ; Cardiac glycosides ; Nierenerkrankung ; Urämie ; Hypertonie ; Herzgefäßsystem ; Herzglykoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Häufung kardialer Komplikationen bei terminaler Niereninsuffizienz ist nicht nur Folge einer chronischen Druckbelastung des linken Ventrikels, obwohl sich der Anteil der Hypertoniker mit fortschreitender renoparenchymatöser Erkrankung von 53 auf 81% erhöht. Andere Faktoren wie Anämie, Hyperparathyreoidismus, autonome Neuropathie und Retention von Elektrolyten, Stoffwechselprodukten oder Toxinen können das Herz schädigen. Ob die Urämie selbst eine Kardiomyopathie verursacht, ist noch nicht geklärt. Befunde über eine verminderte Ca++-Aufnahme während β-adrenerger Stimulation und über eine verminderte Reaktion der Membran-(Na+, K+)-ATPase auf Digitalis lassen eine tiefgreifende Änderung des myokardialen Membranstoffwechsels vermuten. Eine Retention von “endogenem Digitalis” bei Niereninsuffizienz könnte eine Reihe widersprüchlicher Befunde erklären.
    Notes: Summary The high incidence of cardiac complications in endstage renal failure is not only related to the chronic pressure load of the left ventricle, although the proportion of patients with elevated blood pressure increases from 53 to 81% as reno-parenchymal disease progresses. Other factors as anemia, hyperparathyroidism, autonomic neuropathy and retention of electrolytes, metabolic products or toxins may cause damage to the heart. It is a matter of discussion whether uremia itself causes cardiomyopathy. Findings of a reduced Ca++-uptake during β-adrenergic stimulation and a reduced reaction of (Na+, K+)-ATPase to digitalis suggest a basic change of myocardial membrane metabolism. Retention of an “endogenous digitalis” could help to explain some contradictory results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476875
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  • 5
    Electronic Resource
    Electronic Resource
    Measurement of the g-factor of the 90 keV state of Ru^9^9 by the spin rotation method
    Amsterdam : Elsevier
    Physics Letters 13 (1964), S. 330-332 
    Details
    ISSN: 0031-9163
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9163(64)90033-2
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  • 6
    Electronic Resource
    Electronic Resource
    Observation of dipole-octupole mixture in the gamma-decay of the 1174 keV isomeric state of Yb^1^7^2 and its magnetic moment
    Amsterdam : Elsevier
    Nuclear Physics 61 (1965), S. 65-86 
    Details
    ISSN: 0029-5582
    Keywords: Radioactivity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0029-5582(65)90936-3
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  • 7
    Electronic Resource
    Electronic Resource
    Kontrastverstärkung in Scintigrammen mit Hilfe von digitalen Filtern (1970)
    Springer
    Journal of cancer research and clinical oncology 74 (1970), S. 344-348 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Scintigraphie ist eine Methode zur Erkennung und Lokalisation von Tumoren und Metastasen. Zur Verbesserung der Frühdiagnostik ist es wichtig, die Detailerkennbarkeit im Scintigramm weiter zu steigern. Eine geeignete Methode dafür ist die digitale Erfassung und Speicherung der scintigraphischen Meßdaten und die anschließende Filterung der digitalen Scintigramme mit Dekonvolutionsfiltern. Die Möglichkeiten dieser Methode zur Kontrastverstärkung bei Scintigrammen werden untersucht und diskutiert.
    Notes: Summary Scintigraphy is an important method for recognizing and localizing tumors and metastasis. To improve the method it is necessary to improve the recognition of details in the scintigrams. A suitable method for that purpose is the digital registration and storage of the data of the scintigram and the processing of the scintigram by deconvolution filters. The possibilities and limits of such a method for contrast enhancement in scintigrams are examined and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00531216
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  • 8
    Electronic Resource
    Electronic Resource
    Cardiac phase-synchronized myocardial thallium-201 single-photon emission tomography using list mode data acquisition and iterative tomographic reconstruction (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 276-280 
    Details
    ISSN: 1619-7089
    Keywords: Myocardium ; Coronary artery disease ; Myocardial contraction ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to determine whether data acquisition in the list mode and iterative tomographic reconstruction would render feasible cardiac phase-synchronized thallium-201 single-photon emission tomography (SPET) of the myocardium under routine conditions without modifications in tracer dose, acquisition time, or number of steps of the a gamma camera. Seventy non-selected patients underwent201Tl SPET imaging according to a routine protocol (74 MBq/2 mCi201Tl, 180° rotation of the gamma camera, 32 steps, 30 min). Gamma camera data, ECG, and a time signal were recorded in list mode. The cardiac cycle was divided into eight phases, the end-diastolic phase encompassing the QRS complex, and the end-systolic phase the T wave. Both phase- and non-phase-synchronized tomograms based on the same list mode data were reconstructed iteratively. Phase-synchronized and non-synchronized images were compared. Patients were divided into two groups depending on whether or not coronary artery disease had been definitely diagnosed prior to SPET imaging. The numbers of patients in both groups demonstrating defects visible on the phase-synchronized but not on the non-synchronized images were compared. It was found that both postexercise and redistribution phase tomograms were suited for interpretation. The changes from end-diastolic to end-systolic images allowed a comparative assessment of regional wall motility and tracer uptake. End-diastolic tomograms provided the best definition of defects. Additional defects not apparent on non-synchronized images were visible in 40 patients, six of whom did not show any defect on the non-synchronized images. Of 42 patients in whom coronary artery disease had been definitely diagnosed, 19 had additional defects not visible on the non-synchronized images, in comparison to 21 of 28 in whom coronary artery disease was suspected (P〈0.02; χ2). It is concluded that cardiac phase-synchronized201Tl SPET of the myocardium was made feasible by list mode data acquisition and iterative reconstruction. The additional findings on the phase-synchronized tomograms, not visible on the non-synchronized ones, represented genuine defects. Cardiac phase-synchronized201Tl SPET is advantageous in allowing simultaneous assessment of regional wall motion and tracer uptake, and in visualizing smaller defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728763
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  • 9
    Electronic Resource
    Electronic Resource
    Fever of unknown origin: prospective comparison of [18F]FDG imaging with a double-head coincidence camera and gallium-67 citrate SPET (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1617-1625 
    Details
    ISSN: 1619-7089
    Keywords: Fever of unknown origin Gallium-67 citrate [18F]2'-deoxy-2-fluoro-D-glucose Double-head coincidence camera Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Gallium-67 citrate is currently considered as the tracer of first choice in the diagnostic workup of fever of unknown origin (FUO). Fluorine-18 2'-deoxy-2-fluoro-D-glucose (FDG) has been shown to accumulate in malignant tumours but also in inflammatory processes. The aim of this study was to prospectively evaluate FDG imaging with a double-head coincidence camera (DHCC) in patients with FUO in comparison with planar and single-photon emission tomography (SPET) 67Ga citrate scanning. Twenty FUO patients underwent FDG imaging with a DHCC which included transaxial and longitudinal whole-body tomography. In 18 of these subjects, 67Ga citrate whole-body and SPET imaging was performed. The 67Ga citrate and FDG images were interpreted by two investigators, both blinded to the results of other diagnostic modalities. Forty percent (8/20) of the patients had infection, 25% (5/20) had auto-immune diseases, 10% (2/20) had neoplasms and 15% (3/20) had other diseases. Fever remained unexplained in 10% (2/20) of the patients. Of the 20 patients studied, FDG imaging was positive and essentially contributed to the final diagnosis in 11 (55%). The sensitivity of transaxial FDG tomography in detecting the focus of fever was 84% and the specificity, 86%. Positive and negative predictive values were 92% and 75%, respectively. If the analysis was restricted to the 18 patients who were investigated both with 67Ga citrate and FDG, sensitivity was 81% and specificity, 86%. Positive and negative predictive values were 90% and 75%, respectively. The diagnostic accuracy of whole-body FDG tomography (again restricted to the aforementioned 18 patients) was lower (sensitivity, 36%; specificity, 86%; positive and negative predictive values, 80% and 46%, respectively). 67Ga citrate SPET yielded a sensitivity of 67% in detecting the focus of fever and a specificity of 78%. Positive and negative predictive values were 75% and 70%, respectively. A low sensitivity (45%), but combined with a high specificity (100%), was found in planar 67Ga imaging. Positive and negative predictive values were 100% and 54%, respectively. It is concluded that in the context of FUO, transaxial FDG tomography performed with a DHCC is superior to 67Ga citrate SPET. This seems to be the consequence of superior tracer kinetics of FDG compared with those of 67Ga citrate and of a better spatial resolution of a DHCC system compared with SPET imaging. In patients with FUO, FDG imaging with either dedicated PET or DHCC should be considered the procedure of choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000341
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Cardiac phase-synchronized myocardial thallium-201 single-photon emission tomography using list mode data acquisition and iterative tomographic reconstruction (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 276-280 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Myocardium ; Coronary artery disease ; Myocardial contraction ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to determine whether data acquisition in the list mode and iterative tomographic reconstruction would render feasible cardiac phase-synchronized thallium-201 single-photon emission tomography (SPET) of the myocardium under routine conditions without modifications in tracer dose, acquisition time, or number of steps of the a gamma camera. Seventy non-selected patients underwent 201Tl SPET imaging according to a routine protocol (74 MBq/2 mCi 201Tl, 180° rotation of the gamma camera, 32 steps, 30 min). Gamma camera data, ECG, and a time signal were recorded in list mode. The cardiac cycle was divided into eight phases, the end-diastolic phase encompassing the QRS complex, and the end-systolic phase the T wave. Both phase- and non-phase-synchronized tomograms based on the same list mode data were reconstructed iteratively. Phase-synchronized and non-synchronized images were compared. Patients were divided into two groups depending on whether or not coronary artery disease had been definitely diagnosed prior to SPET imaging. The numbers of patients in both groups demonstrating defects visible on the phase-synchronized but not on the non-synchronized images were compared. It was found that both postexercise and redistribution phase tomograms were suited for interpretation. The changes from end-diastolic to end-systolic images allowed a comparative assessment of regional wall motility and tracer uptake. End-diastolic tomograms provided the best definition of defects. Additional defects not apparent on non-synchronized images were visible in 40 patients, six of whom did not show any defect on the non-synchronized images. Of 42 patients in whom coronary artery disease had been definitely diagnosed, 19 had additional defects not visible on the non-synchronized images, in comparison to 21 of 28 in whom coronary artery disease was suspected (P〈0.02; χ2). It is concluded that cardiac phase-synchronized 201Tl SPET of the myocardium was made feasible by list mode data acquisition and iterative reconstruction. The additional findings on the phase-synchronized tomograms, not visible on the non-synchronized ones, represented genuine defects. Cardiac phase-synchronized 201Tl SPET is advantageous in allowing simultaneous assessment of regional wall motion and tracer uptake, and in visualizing smaller defects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728763
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    Paper (German National Licenses)
    Fulltext
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