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  • 1
    Electronic Resource
    Electronic Resource
    Oligodendrocyte abnormalities in shiverer mouse mutant are determined in primary chimaeras (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 357-359 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chimaeras were produced by the aggregation method10"13, which makes it possible to know the interactions among cells. To facilitate the judgement of mosaicism of different genotypes in the brain, C57BL/6N mouse strain (black coat colour) was used as wild-type control, as they have a different ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299357a0
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  • 2
    Electronic Resource
    Electronic Resource
    Human cartilage proteoglycans isolated from normally ossifying and congenitally malformed leg bones (1980)
    Springer
    Calcified tissue international 30 (1980), S. 183-189 
    Details
    ISSN: 1432-0827
    Keywords: Proteoglycans ; Glycosaminoglycans ; Epiphyseal cartilage ; Congenital limb defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Proteoglycans were extracted with 4 M guanidine HC1 solution containing protease inhibitors from various zones of human epiphyseal cartilages of the normally ossifying fibula and cartilaginous rudiment of the tibia of a 12-month-old boy with congenital absence of the tibia, when the knee disarticulation was performed. All the proteoglycan preparations from the epiphyseal cartilages were separated with a sucrose density gradient centrifugation into two components; a heavy, major component and a light one. The molecular size and the proportion of isomeric chondroitin sulfates of polysaccharides of the heavy component differed from those of the light one. The relative amounts of isomeric chondroitin sulfates in the polysaccharide moieties of the components also varied among these zones. The glycosaminoglycan content in the rudimentary tibia was equal to that of the epiphyseal cartilage of the fibula. However, proteoglycan preparations showed neither the normal sedimentation profile with two peaks nor the zonal differences as to the proportion of isomeric chondroitin sulfates. These results suggest that the alterations in proteoglycan metabolism might be involved in the pathogenetic mechanisms producing the congenital limb defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408626
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  • 3
    Electronic Resource
    Electronic Resource
    Increase or decrease of HDL-cholesterol concentrations during pravastatin treatment depending on the pre-treatment HDL cholesterol levels (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 461-463 
    Details
    ISSN: 1432-1041
    Keywords: Key words Pravastatin; hospital information system database ; high density lipoprotein cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The effect of pravastatin was evaluated using patient data accumulated in the data base of a hospital information system (HIS). Methods: We selected 130 patients treated with pravastatin 10 mg per day, for a minimum period of 4 weeks. Results: In the t test analysis, the reduction rates of total cholesterol (TC) and low-density lipoprotein (LDL) levels for pravastatin administration were 18%, and 27%, respectively. These values were similar to previous reports. The high-density lipoprotein (HDL) level, however, did not change significantly, although previous reports have shown an elevation of HDL levels. In an attempt to explain the origin of this difference, we studied the pretreatment value dependence of the cholesterol change using regression analysis. We found that pravastatin raised the HDL level in those cases where pretreatment values were lower than 58 mg · dl−1 and reduced it for higher values. We also showed that the reductions of TC, LDL and triglyceride (TG) levels correlated positively with their pretreatment values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050319
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of food restriction on serotonin metabolism in rat brain (1980)
    Springer
    Neurochemical research 5 (1980), S. 69-79 
    Details
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The brain concentration of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) increased in rats maintained on restricted volume of low-protein or normal-protein diet, whereas these two agents decreased in rats fed low-protein diet ad libitum. In these two food-restricted groups brain 5-HT and 5-HIAA concentrations were not correlated with brain tryptophan hydroxylase activity, but the concentrations correlated closely with cerebral tryptophan concentrations. The cerebral tryptophan concentration in the two food-restricted groups was not consistent with the total or free tryptophan concentration in plasma. In these restricted rats cerebral tryptophan concentration was elevated, and, unlike the plasma tryptophan, it showed no diurnal variation. These results suggested that tryptophan uptake into the brain from plasma was enhanced by limiting food volume intake. Tryptophan uptake was increased by glucagon injection without changing the plasma tryptophan level, but injection of hydrocortisone or insulin had little or no effect on tryptophan concentration in either the plasma or brain.d-Glucose injection elevated plasma tryptophan concentration but decreased brain tryptophan concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964461
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  • 5
    Electronic Resource
    Electronic Resource
    Study of the πpi-system with the GAMS-4000 spectrometer at 100 GeV/c (1998)
    Springer
    The European physical journal 3 (1998), S. 361-371 
    Details
    ISSN: 1434-601X
    Keywords: PACS:14.40.Cs Other mesons with S = C = 0, mass 〈2.5 GeV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The πpi-system produced in the charge exchange π−p-reaction at 100 GeV/c has been studied. The experiment was performed at the CERN SPS accelerator with the multiphoton hodoscope spectrometer GAMS-4000. A partial wave analysis was carried out in the mass range from 0.8 GeV to 3.0 GeV at −t 〈 0.2 (GeV/c)2 with the S, D, G and J waves. The S-wave exhibits rather complicated behaviour with a series of four bumps separated by three dips, at 1 GeV, 1.5 GeV and 2 GeV, which give the evidence for several scalar resonances. Clear peaks corresponding to the f2(1270), f4(2050) and f6(2510) mesons are seen in the higher waves. All the three mesons are produced via a dominating one pion t-channel exchange. The parameters and production cross sections of these mesons are measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500050190
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