ISSN:
1432-1106
Keywords:
Sympathetic ganglion
;
Amino acid metabolism
;
Amino acid transport
;
Postganglionic transection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary One week after sectioning of the postganglionic nerve of the cervical sympathetic ganglion of the rat, most of the nerve cell bodies have degenerated and disappeared from the tissue and have been replaced by Schwann cell elements. Free glutamic and aspartic acid contents in the operated ganglia remain unchanged from the control values. 14C-Labeling of free amino acids from 14C-glucose during incubation of excised ganglia was the same in operated and control ganglia, the major labeling being in free glutamate and aspartate in both cases. After section of the postganglionic nerve, ganglia still accumulated L- or D-glutamate from the surrounding medium for a short period, but for longer incubation time the degree of accumulation was relatively less. The operated ganglia lost the stereospecificity for glutamate transport which was found in normal ganglia. Speculations concerning the biochemical characteristics of amino acid metabolism in neuronal and Schwann cells are presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00238664
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