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  • 1995-1999  (4)
  • 1975-1979
  • Bayesian inference  (2)
  • Bladder cancer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A Bayesian approach to validating STR multiplex databases for use in forensic casework (1997)
    Springer
    International journal of legal medicine 110 (1997), S. 244-250 
    Details
    ISSN: 1437-1596
    Keywords: Key words DNA profiling ; Forensic identification ; Bayesian inference ; Likelihood ratio ; Coancestry ; coefficient ; Probability ; Statistics ; PCR ; STR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract A previous paper in this journal has described the conventional statistical analysis of three databases (Caucasian, Afro-Caribbean and Asians from the Indian subcontinent) where individuals are typed at six short tandem repeat (STR) loci. This paper presents a Bayesian analysis of the same data and the approach is centred on the concept of estimating coancestry coefficients from mixed databases. Posterior distributions for the three databases are presented and discussed and the consequences of implementing bootstrap estimation procedures are also shown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004140050079
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Preclinical evaluation of copper-67 labelled anti-MUC1 mutin antibody C595 for therapeutic use in bladder cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 439-443 
    Details
    ISSN: 1619-7089
    Keywords: Radioimmunotherapy ; MUC1 mucin ; Monoclonal antibody ; Copper-67 ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transitional cell carcinoma of the bladder is the fifth commonest cause of death from cancer in men in the United Kingdom. Most patients present early with superficial disease, though with current treatment up to 20% progress to invasive disease, which has a poor prognosis. Better local treatments are required to limit this tumour progression. The ease of access to the bladder via a catheter provides the ideal opportunity for antibody (Ab) targeted therapy. We have previously shown that indium-111 labelled anti-MUCI mucin Ab C595 selectively localises to bladder tumours after intravesical administration. We have selected copper-67 as an alternative radiolabel with suitable physical characteristics for radioimmunotherapy. This communication demonstrates that C595 can be reproducibly labelled with67Cu and that the radioimmunoconjugate is both stable and maintains high immunoreactivity. Pilot studies on cystectomy specimens in a novel ex vivo system and in one patient confirmed the ability of this conjugate to localise to tumour after intravesical administration. On the basis of these studies we are now in a position to study the intravesical administration of67Cu-labelled C595 in patients with bladder cancer with a view to a therapeutic trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881818
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Preclinical evaluation of copper-67 labelled anti-MUC1 mucin antibody C595 for therapeutic use in bladder cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 439-443 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Radioimmunotherapy ; MUC1 mucin ; Monoclonal antibody ; Copper-67 ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Transitional cell carcinoma of the bladder is the fifth commonest cause of death from cancer in men in the United Kingdom. Most patients present early with superficial disease, though with current treatment up to 20% progress to invasive disease, which has a poor prognosis. Better local treatments are required to limit this tumour progression. The ease of access to the bladder via a catheter provides the ideal opportunity for antibody (Ab) targeted therapy. We have previously shown that indium-111 labelled anti-MUC1 mucin Ab C595 selectively localises to bladder tumours after intravesical administration. We have selected copper-67 as an alternative radiolabel with suitable physical characteristics for radioimmunotherapy. This communication demonstrates that C595 can be reproducibly labelled with 67Cu and that the radioimmunoconjugate is both stable and maintains high immunoreactivity. Pilot studies on cystectomy specimens in a novel ex vivo system and in one patient confirmed the ability of this conjugate to localise to tumour after intravesical administration. On the basis of these studies we are now in a position to study the intravesical administration of 67Cu-labelled C595 in patients with bladder cancer with a view to a therapeutic trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881818
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Bayesian analysis of contingency tables: a simulation and graphics-based approach (1996)
    Springer
    Statistics and computing 6 (1996), S. 277-287 
    Details
    ISSN: 1573-1375
    Keywords: Bayesian inference ; contingency tables ; Gibbs sampling ; graphical methods ; hypothesis testing ; independence ; intraclass tables ; model comparison ; predictive densities ; quasisymmetry ; simulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract In this paper we present a simulation and graphics-based model checking and model comparison methodology for the Bayesian analysis of contingency tables. We illustrate the approach by testing the hypotheses of independence and symmetry on complete and incomplete simulated tables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00140872
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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