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  • 1
    Electronic Resource
    Electronic Resource
    Personality traits of anaesthetists and physicians: an evaluation using the Cloninger Temperament and Character Inventory (TCI-125) (1999)
    Oxford : Blackwell Science Ltd
    Anaesthesia 54 (1999), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The personality profiles of Specialist Anaesthetists, Trainee Anaesthetists and Specialist Physicians were examined using Cloninger's Temperament and Character Inventory. These were compared with validated Community Sample ‘average values’ and a historical Norwegian Physician sample. Completed forms were returned from 364 doctors (Specialist Anaesthetists 222, Trainee Anaesthetists 75, Physicians 67), an overall response rate of 71%. Specialist Anaesthetists were more Cooperative, Harm Avoidant and Self-Directed than the Community Sample but less Reward Dependent, Novelty Seeking and Persistent than the Community Sample. Physicians were more Cooperative than their Specialist Anaesthetist colleagues, but both more so than were the general population. Trainee anaesthetists appear to be more Novelty Seeking and Reward Dependent than the Specialist Anaesthetists, this factor being predominately age related. Extreme/Mild personality traits were identified in 33% of Specialists, 41% of Trainees and 33% of Physicians, whilst personality disorders were found at the expected rates (Specialist Anaesthetists 9%, Trainee Anaesthetists 10%, Physicians 2%). Personality assessment has implications for recruitment, crisis management and professional development within anaesthesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1999.01112.x
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  • 2
    Electronic Resource
    Electronic Resource
    Malignant hyperthermia—a large kindred linked to the RYR1 gene (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Malignant hyperthermia susceptibility is genetically heterogeneous. The ryanodine receptor gene on the long arm of chromosome 19 represents an important candidate gene but not all families with malignant hyperthermia demonstrate ryanodine receptor mutations or linkage to this region of 19q. Linkage to chromosome 17 in the region of the adult muscle sodium channel α subunit gene has been suggested in some families; others are not linked to either of these loci. For most families the in vitro muscle contracture test remains the only reliable method of predicting susceptibility to malignant hyperthermia. We have performed linkage analysis in a large family group with malignant hyperthermia in which the in vitro muscle contracture test had been carried out using the procedure standardised by the European Malignant Hyperthermia Group. None of the published ryanodine receptor gene mutations associated with malignant hyperthermia susceptibility were detected in affected individuals but linkage to intragenic ryanodine receptor markers strongly suggest that this gene is involved in malignant hyperthermia susceptibility in this family. This enabled accurate predictive testing by DNA analysis in 11 untested subjects at 50% risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1996.tb07647.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of cytomorphological and architectural heterogeneity in mammographically-detected ductal carcinoma in situ (1996)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 28 (1996), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Many classification schemes have been proposed for ductal carcinoma in situ. Architectural heterogeneity is widely recognized. Cytonuclear grade appears to have greater prognostic significance than architectural pattern. This study assesses heterogeneity using a classification based on cytological grade and compares this to architectural heterogeneity in mammographically detected ductal carcinoma in situ. One hundred and twelve cases were classified according to architectural subtypes and the carcinoma nuclei were graded. Necrosis and micro- calcification were assessed. Eighty-four percent of ductal carcinomas in situ had a single nuclear grade, whereas only 39% showed a single architectural pattern. High grade nuclei were present in 87% of cases. Necrosis was associated with high nuclear grade. In contrast to architectural heterogeneity, this study shows little ductal carcinoma in situ heterogeneity when classification is based on nuclear grade. Thus, a cytomorphological classification should have the advantage of consistency and reproducibility in comparison to architecture-based classification systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1996.322365.x
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  • 4
    Electronic Resource
    Electronic Resource
    Prediction of infusion rates of rocuronium using the bolus test dose technique (1997)
    Oxford : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-four patients were given a loading dose of rocuronium 1.0 mg.kg−1 intravenously followed by boluses of 20 mg (n = 19) and 10 mg (n = 24) after return of T1 of the train-of-four to 5% of control. Neuromuscular function was assessed using a Relaxograph. The time was recorded for the return of T1 to 5% after the administration of the boluses and subsequently an infusion of rocuronium was started. The aim was to maintain T1 between 3% and 7% of control for at least 40 min without a change of infusion rate. The correlations between the duration of the test doses and the infusion rates were −0.94 (10 mg) and −0.86 (20 mg). The predictive accuracy of the 10 mg bolus was assessed in a further 10 patients. At the termination of the infusion three patients had a T1% that was outside the desired range of 3–7%. A 10 mg bolus that lasts 6 min indicates a need for an infusion of at least 60 mg.h−1, 8 min (50 mg.h−1), 10 min (40 mg.h−1), 15 min (30 mg.h−1), 24 min (20 mg.h−1) and 34 min (15 mg.h−1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1997.001-az004.x
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  • 5
    Electronic Resource
    Electronic Resource
    INSTRUMENTAL AND SENSORY MEASUREMENT OF BEEF PATTY AND SAUSAGE TEXTURE (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of muscle foods 10 (1999), S. 0 
    Details
    ISSN: 1745-4573
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Beef sausages and beef patties of different texture were produced by varying the fat content in the raw mix over the range 5–30%. Batter shear stress and strain increased linearly with increased fat level (P〈0.09 and 0.001, respectively). Although batter shear stress was not related to sensory scores, shear strain was directly related to moistness and inversely related to grittiness scores (P〈0.05). Batter sensory moistness increased and firmness and grittiness deceased linearly with fat content (P〈0.001). Changes in fat content did not affect the peak force of cooked patties, and there were poor correlations between patty peak force and sensory scores. Patty juiciness and softness increased and patty cohesiveness and chewiness decreased with fat content (P〈0.001). Batter cook yield increased and patty cook yield decreased with increasing fat level (P〈0.001). Sensory scores, using trained panelists, were more sensitive to the effect of fat content on patty and sausage texture than instrumental measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4573.1999.tb00384.x
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  • 6
    Electronic Resource
    Electronic Resource
    Thomas, Huw; Krishnarayan, Vijay: Race Equality and Planning: Policies and Procedures : Avebury, Aldershot, 1994 (1995)
    Cambridge : Cambridge University Press
    Journal of social policy 24 (1995), S. 156-156 
    Details
    ISSN: 0047-2794
    Source: Cambridge Journals Digital Archives
    Topics: Political Science , Sociology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0047279400024788
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  • 7
    Electronic Resource
    Electronic Resource
    Odontogenic myxoma in an adolescent with tuberous sclerosis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 26 (1997), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tuberous sclerosis is a hamarloneoplastic syndrome characterised by early onset of convulsive seizures with mental retardation. Oral abnormalities, including enamel hypoplasia and mucosal fibromas, have been previously reported. We report here a 17-year-old girl with this disorder who had received repeated dental trauma. She presented with a swelling associated with a traumatised maxillary central incisor that suggested a diagnosis other than the Odontogenic myxoma found at operation. Odontogenic myxoma has not previously been reported in this condition; it may represent an unusual phenotypic expression of the genetic defect understood to determine tuberous sclerosis, or it may be an unrelated coincidental finding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1997.tb00226.x
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  • 8
    Electronic Resource
    Electronic Resource
    The assessment of postmortem brain volume; a comparison of stereological and planimetric methodologies (1999)
    Springer
    Neuroradiology 41 (1999), S. 493-496 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Stereology ; Planimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We compared two methods of estimating the volume of 10 formalin-fixed brains using MRI. MRI was performed and total brain volume was then assessed using two distinct techniques: a stereological point-counting technique based on the Cavalieri principle, and an edge-tracing technique. The total brain volumes obtained using these two techniques were similar and correlated closely with each other (r = 0.97). Both methods could be optimised to a similar degree while maintaining the coefficient of error at an acceptably low level. However, the stereological assessment of brain volume required between 20 min and 30 min per brain, depending on the number of points per sampling grid, compared with 1 h per brain using the planimetric method. Thus, while planimetric and stereological approaches yield very similar results, the stereological method has the advantage of greater speed and, therefore, efficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050789
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  • 9
    Electronic Resource
    Electronic Resource
    A cDNA from the arbuscular mycorrhizal fungus Glomus versiforme with homology to a cruciform DNA-binding protein from Ustilago maydis (1998)
    Springer
    Mycorrhiza 7 (1998), S. 301-306 
    Details
    ISSN: 1432-1890
    Keywords: Key words Arbuscular mycorrhiza ; Differential screening ; Gv1 ; HMP1 ; Roots
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A cDNA clone (Gv1) was isolated from a Medicago truncatula/Glomus versiforme root cDNA library by a differential screening technique. Gv1 represents a full-length G. versiforme mRNA encoding a 99-amino-acid polypeptide. This shares regions of identity with HMP1, a non-histone, cruciform DNA-binding protein from Ustilago maydis. Northern blot analysis indicated that Gv1 transcripts were present in mycorrhizal roots of M. truncatula and M. sativa (alfalfa), but absent in uncolonized roots of both species. A reverse transcription/polymerase chain reaction (RT-PCR) technique detected transcripts in the roots of the M. sativa non-mycorrhizal genotype MN NN-1008 colonized with G. versiforme, as well as in external hyphae collected from the roots of M. sativa colonized with G. versiforme. A genomic copy of Gv1 was detected by PCR in DNA isolated from the roots of M. truncatula colonized with G. versiforme and in DNA isolated from spores of G. versiforme. The PCR product identified in the mycorrhizal DNA preparation was identical in sequence to the cDNA, except for the presence of two introns. A homologue of Gv1 was detected in a second arbuscular mycorrhizal fungus, Glomus intraradices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005720050196
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  • 10
    Electronic Resource
    Electronic Resource
    High magnetic susceptibility coatings for visualisation of optical fibres on a specialised interventional MRI system (1997)
    Springer
    European radiology 7 (1997), S. 1341-1342 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Magnetic resonance imaging (MRI) ; Interventional MRI ; Fibre optics ; Laser therapy ; MR-guided therapy ; Specialised MRI systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to develop methods of visualising optical fibres on MRI scans for monitoring interstitial laser therapy. Scans were performed on a specialised MRI extremity scanner at 0.17 T. Optical fibres of 0.4 mm diameter used for delivering laser energy were coated with iron particles from a superferromagnetic contrast agent. MR images of the fibres were acquired using gradient echo sequences (TR/TE = 300/10, 1 mm in-plane, 3 mm slice) and assessed for fibre visibility. Coated fibres could be resolved as lines 2 ± 1 mm wide using the gradient echo sequence. Uncoated fibres were invisible on the sequences used for in vivo therapy monitoring due to partial volume averaging. It is concluded that optical fibre visualisation by MRI may be improved by coating with ferromagnetic particles. Biocompatibility requires further assessment, but direct coating appears to be a promising method for fibre visualisation in MR-guided laser therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050300
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