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  • 1
    Electronic Resource
    Electronic Resource
    The allergens of nail polish (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nail polish that has completely dried on the fingernails contains water-soluble components that attain the skin during extensive but transient contact. This was proven by water extraction of thin layers of nail polish that had been painted onto glass plates and allowed to dry for 3 days. Comparing the isolated fractions and compounds with known nail polish ingredients revealed that the water-soluble substances are para- and ortho-toluenesulfonamide. Dihuty1 phthalate and 3 constituents of toluenesulfonamide-formaldehyde resin (TS-F-R), which is the basic material of almost all nail polishes sold worldwide. 12 female patients with proven nail polish allergy were patch tested with 21 nail polish components, including those isolated. Only 2 fractions were positive. These contained a monomer and a dimer created during condensation of TS-F-R. Their structures were elucidated. The 3rd compound, a trimer, remained negative, except in 1 case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb00537.x
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  • 2
    Electronic Resource
    Electronic Resource
    Structure-activity relationships in allergic contact dermatitis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Primin (2-methoxy-6-pentyl-1,4-benzoquinone)is a naturally-occurring strong sensitizer from Primula obconica (Primulaceae), To determine the effect of side-chain length on senstizing potency 15 analogues with linear side chains from to from C1, to C15 and 4 C6- analogues with branched side chains were prepared synthetically and devoted to experimental sensitization in guinea pigs The results showed an increase of the sensitizing capacity with increasing length of the alkyl side chain from C1 to C10, reaching a maximum at C11 and C12. On further elongation the senstizing potency decreased beyond C13 reaching values which finally were as low as those of the C1 and C3 derivatives. The results mirror finding which finally were as low as those of the C1 and C3 derivatives. The results mirror findings which formerly have been obtained with other non-quinonoid compounds like catechols, phenols hydroquinones and gallates. In the plant kingdom. Compound approximating an “ideal allergen” consisting of a quinonoid ring with a 10 or 11 carbon-remarkably strong sensitizer found in Wigandia caracasana (Hydrophyllaceae)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1995.tb00440.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549) (1999)
    Oxford BSL : Blackwell Science Ltd
    Clinical & experimental allergy 29 (1999), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cetirizine, a H1-receptor antagonist, exerts besides its well-known anti-allergic potential an array of anti-inflammatory activities. In particular epithelial cells activated in the presence of cetirizine showed a reduced ICAM-1 cell surface expression and a diminished release of sICAM-1.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveWe wondered whether cetirizine might influence the release of interleukin-8 (IL-8) from human epithelial cells activated with agonists distinct from histamine.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsWe used the human lung epithelial cell line A549 for our in vitro studies. IL-8 release was determined by IL-8 enzyme immunoassay, the intracellular staining for IL-8 and NF-kB was analysed by FACS analysis and IL-8 mRNA steady state level was studied by Northern blot analysis. Confluent epithelial cell monolayer were pre-incubated with cetirizine (0.01 −1.0 μmol/L) for 30 min and afterwards activated with pro-inflammatory cytokines (TNF-α IL-1β, IL-6, IFN-γ) or different agonists (PMA, NaF, respiratory syncytial virus [RSV]) for 24 h.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsEpithelial cells stimulated with TNF-α IL-1β, PMA and RSV, respectively, showed a significantly increased release of IL-8. Pre-incubation with cetirizine diminished the IL-8 release from cells activated with TNF-α or PMA in a significant manner. The reduced IL-8 release coincided with a diminished percentage of cells expressing IL-8. Northern blot analysis revealed a reduced steady state level of IL-8 mRNA in cells pretreated with cetirizine and stimulated with TNF-α. Furthermore, a decreased amount of accessible DNA-binding sites of the nuclear factor kappa B (NF-kB) was determined by FACS analysis.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsThese results suggest that cetirizine reduced the release of IL-8 from A549 cells stimulated with PMA and TNF-α, respectively, by lowering IL-8 gene expression. Therefore, cetirizine might exert anti-inflammatory effects beyond its H1-receptor antagonistic activity in the course of inflammatory respiratory tract disorders such as bronchial asthma and allergic rhinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.1999.00630.x
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  • 4
    Electronic Resource
    Electronic Resource
    G-proteins in allergy (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1997.tb02576.x
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  • 5
    Electronic Resource
    Electronic Resource
    Weak e+e− lines from internal pair conversion observed in collisions of 238U with heavy nuclei (1998)
    Springer
    The European physical journal 1 (1998), S. 27-37 
    Details
    ISSN: 1434-601X
    Keywords: PACS:14.60.Cd Electrons and positrons – 23.20.Ra Internal pair production – 25.70.Bc Elastic and quasielastic scattering – 25.70.De Coulomb excitation – 25.70.Hi Transfer reaction – 29.30.Aj Charged-particle spectrometers: electric and magnetic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We present the results of a Doppler-shift correction to the measured e+e−–sum-energy spectra obtained from e+e−–coincidence measurements in 238U +206Pb and 238U +181Ta collisions at beam energies close to the Coulomb barrier, using an improved experimental setup at the double-Orange spectrometer of GSI. Internal-Pair-Conversion (IPC) e+e− pairs from discrete nuclear transitions of a moving emitter have been observed following Coulomb excitation of the 1.844 MeV (E1) transition in 206Pb and neutron transfer to the 1.770 MeV (M1) transition in 207Pb. In the collision system 238U +181Ta, IPC transitions were observed from the Ta-like as well as from the U-like nuclei. In all systems the Doppler-shift corrected e+e−–sum-energy spectra show weak lines at the energies expected from the corresponding γ–ray spectra with cross sections being consistent with the measured excitation cross sections of the γ lines and the theoretically predicted IPC coefficients. No other than IPC e+e−–sum-energy lines were found in the measured spectra. The transfer cross sections show a strong dependence on the distance of closest approach (Rmin), thus signaling also a strong dependence on the bombarding energy close to the Coulomb barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500050028
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  • 6
    Electronic Resource
    Electronic Resource
    Mikrowellenhyperthermie und Onkolyse durch Clostridien (1975)
    Springer
    Naturwissenschaften 62 (1975), S. 541-542 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609084
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  • 7
    Electronic Resource
    Electronic Resource
    Communication in the migratory termite-hunting ant Pachycondyla (= Termitopone) marginata (Formicidae, Ponerinae) (1996)
    Springer
    Journal of comparative physiology 178 (1996), S. 47-53 
    Details
    ISSN: 1432-1351
    Keywords: Recruitment trails ; Pheromones ; Pygidial gland ; Citronellal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Neotropical species Pachycondyla marginata conducts well-organized predatory raids on the termite species Neocapritermes opacus and frequently emigrates to new nest sites. During both activities the ants employ chemical trail communication. The trail pheromone orginates from the pygidial gland. Among the substances identified in the pygidial gland secretions, only citronellal was effective as a trail pheromone. Isopulegol elicited an increase in locomotory activity in the ants and may function as a synergist recruitment signal. The chemical signal is enhanced by a shaking display performed by the recruiting ant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189589
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  • 8
    Electronic Resource
    Electronic Resource
    Histamin in der Interstitialflüssigkeit der befallenen und klinisch nicht befallenen Haut bei chronisch rezidivierender Urticaria (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 269-276 
    Details
    ISSN: 1432-069X
    Keywords: Chronic urticaria ; Histamine ; Interstitial fluid ; Histamine determination with autoanalyzer technique ; Chronisch rezidivierende Urticaria ; Histamin ; Interstitialflüssigkeit ; Histamin-Bestimmung mit Autoanalyzer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 8 Patienten mit idiopathischer chronisch rezidivierender Urticaria wurden in der Periumbilicalregion Saugblasen gleichzeitig auf frischen urticariellen Herden und der unveränderten Haut daneben produziert und Histamin in der Blasenflüssigkeit bestimmt. Hierzu wurde die von Siraganian entwickelte Methode der Autoanalyzer-Technik in modifizierter Form verwendet. Die Histaminspiegel lagen bei diesen Patienten in unveränderter Haut in derselben Größenordnung wie bei 10 Normalpersonen, während alle 8 Urticaria-Patienten höhere Histamin-Werte in den Urticae verglichen mit der nicht befallenen Haut aufwiesen; bei 4 der Patienten waren diese Unterschiede jedoch nur gering ausgeprägt.
    Notes: Summary In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60–120 min. The blister fluid histamine was determined with a modified autoanalyzer technique developed by Siraganian. In this method the extraction of histamine, the condensation of o-phthaldialdehyde with histamine and the measurement of the fluorochrome is automated. With the described method it is possible to measure values less than 0.5 ng/ml. Histamine levels in perilesional skin were nearly in the same range as in the periumbilical skin of 10 normal persons. The range of the normal tissue fluid histamine levels was 0–15 ng/ml and they did not differ significantly from the plasma levels. In all 8 patients with chronic urticaria the histamine values were higher in lesional than in perilesional skin. In 1 patient the lesional blister fluid histamine value reached 35.5 ng/ml. Four of the patients showed only low differences (less than 3 ng/ml).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418572
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  • 9
    Electronic Resource
    Electronic Resource
    (S)-2-Methyl-1-hexanol, characteristic mandibular gland substance of ants of theCataglyphis bicolor group (1996)
    Springer
    Chemoecology 7 (1996), S. 57-60 
    Details
    ISSN: 1423-0445
    Keywords: mandibular glands ; chemotaxonomy ; chirality ; synthesis ; 2-methyl-1-hexanol ; Hymenoptera ; Formicidae ; Formicinae ; Cataglyphis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In all the species of theCataglyphis bicolor group examined yet, i.e.C. bicolor, C. diehli, C. isis, C. nodus, andC. viaticus, 2-methyl-1-hexanol is the characteristic substance and almost the only substance found in the mandibular glands. Its chirality has been determined inC. bicolor and shown to be exclusively (S)-2-methyl-1-hexanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240638
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  • 10
    Electronic Resource
    Electronic Resource
    Stoffwechselprodukte von Mikroorganismen (1976)
    Springer
    Archives of microbiology 107 (1976), S. 143-160 
    Details
    ISSN: 1432-072X
    Keywords: New nucleoside-peptide antibiotic ; Chitin biosynthesis ; Structure elucidation ; Mass spectrometry ; Streptomyces tendae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Der Streptomycet Tü 901, Streptomyces tendae, bildet ein antifungisch wirkendes Nukleosid-Antibioticum, Nikkomycin. Als Angriffsort kommt die Chitinsynthese in Frage. Mit Hilfe der Massenspektrometrie und des chemischen Abbaus konnten Uracil, eine Aminohexuronsäure und eine neue, einen Pyridinring enthaltende Aminosäure nachgewiesen werden.
    Notes: Abstract From the fermentation broth of Streptomyces tendae Tü 901 a substance was isolated, which inhibits the growth of several fungi. The new antibiotic affects the chitchin biosynthesis. Its structure was identified by mass spectrometry of the products obtained after chemical degradation. Nikkomycin is a nucleoside-peptide antibiotic consisting of uracil, an amino hexuronic acid and a new amino acid containing a pyridin ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446834
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