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  • 1995-1999  (5)
  • 1970-1974
  • Gadolinium  (3)
  • Analytical Chemistry and Spectroscopy  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 39 (1997), S. 446-449 
    ISSN: 1432-1920
    Keywords: Key words Arachnoid diverticula ; Spine ; Magnetic resonance imaging ; Gadolinium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our goal was to find MRI signs of use for identifying a spinal arachnoid diverticulum. Three cases of spinal arachnoid diverticula, one extradural and two intradural, were examined on a 1.5 T imager. There was obvious mass effect on the adjacent structures in one case and increased signal intensity in the diverticulum on proton density- and T2-weighted images in two cases. Signal changes due to turbulent movement of the spinal fluid inside the diverticula were seen in all cases on sagittal fast spin-echo (FSE) proton density- and T2-weighted images; it was difficult to tell whether these signal changes imply a communication or are simply FSE artefacts. On contrast-enhanced studies, all cases showed partial enhancement inside the diverticula. There thus are four signs of diverticula: mass effect, the increased signal, signal void sign and partial enhancement; the last of these, the most reliable, has never been reported before.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 38 (1996), S. S114 
    ISSN: 1432-1920
    Keywords: Key words Spine ; haemorrhage ; Gadolinium ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous spinal epidural haematoma (SSEH) is uncommon, but central gadolinium (Gd) enhancement of the haematoma is even rarer. To our knowledge, only one case has been reported, but no explanation was given concerning the mechanism of this enhancement. We present a case of SSEH with unusual central Gd enhancement which we believe is due to oozing from the injured posterior internal venous plexuses. Therefore, although rare, central Gd enhancement of an epidural mass should not rule out the possibility of a haematoma.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 38 (1996), S. S114 
    ISSN: 1432-1920
    Keywords: Spine, haemorrhage ; Gadolinium ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spontaneous spinal epidural haematoma (SSEH) is uncommon, but central gadolinium (Gd) enhancement of the haematoma is even rarer. To our knowledge, only one case has been reported, but no explanation was given concerning the mechanism of this enhancement. We present a case of SSEH with unusual central Gd enhancement which we believe is due to oozing from the injured posterior internal venous plexuses. Therefore, although rare, central Gd enhancement of an epidural mass should not rule out the possibility of a haematoma.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1315-1320 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Matrix-assisted laser desorption/ionization (MALDI) was used for several small proteins (such as insulin) and for peptides. It was found that the detection efficiencies of MALDI for the insulin B chain and the insulin A chain are drastically different. Similar phenomena were also observed for various types of peptides. The positive-ion signal of MALDI in detecting proteins or peptides was found to be greatly enhanced by the presence of a basic amino acid in their chains. The experimental results indicate that this enhancement may arise from proton transfer in solution by an acid-base reaction between the protein/peptide and matrix molecule. This pre-protonated mechanism provides a low energy barrier for the ionization of peptides in a MALDI process, and greatly reduces the energy threshold of MALDI. Matrix effects on the ionization mechanism are discussed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The most common mutation of the cystic fibrosis gene is characterized by the deletion of three nucleotides that code phenylalanine in the 508 position of the cystic fibrosis transmembrane conductance regulator. We report the first measurements by matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry for the ΔLF508 mutation in cystic fibrosis carriers and patients. Furthermore, in a blind test, results from the normal and ΔLF508 mutant alleles in 30 clinical samples based on MALDI mass spectrometry and on conventional gel analysis of the DNA were in total agreement. These results demonstrate the utility of MALDI mass spectrometry in the molecular diagnosis of mutant alleles and point to its potential use for ultra-fast detection in large-scale screening of DNA mutations.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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