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  • 1995-1999  (1)
  • 1970-1974  (15)
  • 1
    Electronic Resource
    Electronic Resource
    Animal model of experimentally induced ectopic enchondral ossification in nude mice with xenograft of porcine epiphyseal cartilage (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 165-168 
    Details
    ISSN: 1432-1440
    Keywords: Key words Nude mice ; Transplantation ; Epiphyseal growth plate ; Ossification ; Development of long bones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a specific animal model the induction of heterologous enchondral ossification was examined in long term follow-up. Physiologically normal and devitalized frozen porcine epiphyseal cartilage as a control group were transplanted as s.c. xenograft into athymic nude mice (nu/nu). 15 weeks after transplantation the porcine growth plate cartilage showed the development of viable cartilage tissue in the recipients, further differentiating to juvenile longe bone with epiphysis, diaphysis and growth plate. Porcine growth plate cartilage increased s.c. in the recipient nude mice, showing enchondral ossification without any physiological load, and finally an unexpected development towards complete juvenile long bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050328
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of pancreas tumours by di-isopropanolnitrosamine (1974)
    Springer
    Naturwissenschaften 61 (1974), S. 328-328 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00599567
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  • 3
    Electronic Resource
    Electronic Resource
    Carcinogenicity ofβ-hydroxylated dipropylnitrosamine (1973)
    Springer
    Naturwissenschaften 60 (1973), S. 55-55 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591776
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Simultaneous tumors in the respiratory system and urinary bladder of syrian golden hamsters (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 153-158 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.
    Notes: Summary The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284500
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of intraperitoneal injections of dimethyl- and diethylnitrosamine, alone or simultaneously on Swiss mice (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 233-238 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
    Notes: Summary Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304061
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  • 6
    Electronic Resource
    Electronic Resource
    The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 98-107 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die kombinierte Verabreichung von Methylcholanthren (MCA) (intragastrisch) und Dimethylnitrosamin (DMN) (intraperitoneal) führte bei Swiss-Mäusen zu erhöhter Tumorrate bei verkürzter Latenzzeit im Vergleich zu Tieren, die jeweils nur mit einer der beiden Substanzen behandelt wurden. In der MCA+DMN-Gruppe fanden sich vermehrt Lungencarcinome, Neoplasmen der Nieren und Lymphome. Bei den Tieren der DMN-Gruppe zeigten sich gehäuft Gefäßtumoren. Die Befunde der MCA + DMN-Gruppe werden als syncarcinogene Wirkung der Substanzen diskutiert.
    Notes: Summary The combined application of MCA (i.g.) and DMN (i.p.) to Swiss mice resulted in an increased incidence of tumors and in a decreased tumor latency, compared with the animals treated with each compound alone. In the MCA+DMN group the rate of lung carcinomas and neoplasms of the kidney was found to be significantly enhanced, while the DMN group showed an increase of vascular tumors. In the MCA group malignant lymphomas were seen more frequently than in the other groups. The findings concerning the lung and kidney were interpreted as a syncarcinogenic effect of the combined application of MCA + DMN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284384
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative studies of neoplastic response to a single dose of nitroso compounds (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 85-89 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach einmaliger intraperitonealer, subcutaner oder intragastrischer Behandlung mit N-Dibutylnitrosamin (DBN) fanden sich bei Syrischen Goldhamstern vorwiegend papilläre Tumoren der Trachea. Die Untersuchungen zeigten die Abhängigkeit der Tumorrate von der Höhe der Carcinogendosis, jedoch nicht von der Art der Verabreichung. Neoplasmen der Harnblase, wie sie sich nach chronischer DBN-Gabe zeigten, wurden mit Einzeldosen (150–1600 mg/kg) nicht induziert.
    Notes: Summary After intraperitoneal, subcutaneous, and intragastric treatment with a single dose of dibutylnitrosamine (DBN), Syrian golden hamsters showed mainly papillary tumors of the trachea. The experiments have shown that tumor incidence was dependent upon the administered dose without regard to route of application. A single dose (150–1600 mg/kg) of DBN did not lead to the development of neoplasms in the urinary bladder, as was found after chronic application of the compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284382
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  • 8
    Electronic Resource
    Electronic Resource
    The carcinogenic effect of 2-oxo-propyl-propylnitrosamine in Sprague-Dawley rats (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 23-28 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chronische Wirkung von 2-Oxo-propyl-propylnitrosamin (2-OPPN) wurde an Sprague-Dawley Ratten untersucht. Die Tiere zeigten vorwiegend hepatocelluläre Carcinome, die Wirkung dieses Carcinogens war dosisabhängig. Die Ergebnisse wurden unter der Annahme diskutiert, daß 2-OPPN möglicherweise ein Metabolit des Di-n-propylnitrosamins ist.
    Notes: Summary The chronic effect of 2-oxo-propyl-propylnitrosamine (2-OPPN) was examined in Sprague-Dawley rats. The animals showed mainly hepatocellular carcinomata; the effect of the carcinogen was dose dependent. The findings are discussed under the assumption that 2-OPPN might be a metabolite of di-n-propylnitrosamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303597
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of nitrosamines on nursing syrian golden hamsters and their offspring (1972)
    Springer
    Journal of cancer research and clinical oncology 78 (1972), S. 73-77 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Syrische Goldhamster erhielten während der Säugeperiode Diäthylund Dibutylnitrosamin. Bei den behandelten Mutterund auch den Jungtieren entstanden Papillome im Respirationstrakt. Die Gesamtzahl der Tumoren in der F1-Generation zeigte abhängig von der Konzentration des den Muttertieren verabreichten Carcinogens eine Zunahme. Nach ersten Ergebnissen erscheint Diäthylnitrosamin unverändert in der Milch. Die Untersuchungen zeigen somit, daß die Carcinogene oder ihre Metaboliten nicht nur transplacentar, sondern auch über die Milch vom Muttertier ins Jungtier gelangen.
    Notes: Summary Syrian golden hamsters were treated while nursing. Mothers as well as offspring developed tumors of the respiratory system. Total number of neoplasms increased in the F1generation as doses given to the P-generation increased. Preliminary results have shown that DEN in measurable amounts appeared unchanged in the milk. The findings indicated that the lactating mammary gland transmitted the carcinogens or their metabolites as found previously for the placenta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284314
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  • 10
    Electronic Resource
    Electronic Resource
    Melanoma in the North of Thailand in the last ten years (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 31-35 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Gewebsproben der Melanomfälle der letzten 10 Jahre aus dem Pathologischen Institut der Universität Chiang Mai, Nord-Thailand, wurden nachuntersucht und soweit erhältlich, die Angaben der Krankengeschichten bei der Auswertung berücksichtigt. Unterschiede hinsichtlich der Lokalisation sowie der Häufigkeit der Melanome in bezug zum Alter und Geschlecht wurden beschrieben. Über 50% der Geschwülste zeigten sich im Bereich der unteren Extremitäten; Männer erkrankten häufiger als Frauen.
    Notes: Summary The cases of melanoma diagnosed at the Chiang Mai University Medical School in the last ten years were histologically re-examined and the case histories, when avalaible, were evaluated. The different anatomical locations of melanoma related to age and sex of the patients were analysed. More than 50% of the melanomas were found on the lower extremities. The frequency of the tumours was higher in males than in females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285312
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