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Uteroglobin: a novel cytokine? (1999)

Mukherjee, A. B. ; Kundu, G. C. ; Mantile-Selvaggi, G. ; [et al.]

Springer

Cellular and molecular life sciences 55 (1999), S. 771-787

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ISSN: 1420-9071

Keywords: Key words. Blastokinin; uteroglobin; CC10; ECM; fibronectin; PLA2; receptor; cytokine.

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract. Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, multifunctional protein secreted by the mucosal epithelia of virtually all mammals. It is present in the blood and in other body fluids including urine. An antigen immunoreactive to UG antibody is also detectable in the mucosal epithelia of all vertebrates. UG-binding proteins (putative receptor), expressed on several normal and cancer cell types, have been characterized. The human UG gene is mapped to chromosome 11q12.2 – 13.1, a region that is frequently rearranged or deleted in many cancers. The generation of UG knockout mice revealed that disruption of this gene causes: (i) severe renal disease due to an abnormal deposition of fibronectin and collagen in the glomeruli; (ii) predisposition to a high incidence of malignancies; and (iii) a lack of polychlorinated biphenyl binding and increased oxygen toxicity in the lungs. The mechanism(s) of UG action is likely to be even more complex as it also functions via a putative receptor-mediated pathway that has not yet been clearly defined. Molecular characterization of the UG receptor and signal transduction via this receptor pathway may show that this protein belongs to a novel cytokine/chemokine family.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s000180050331

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Endgroup studies in poly (methyl methacrylate) initiated by redox systems containing reducing sulfoxy compounds in aqueous media (1966)

Mukherjee, A. R. ; Ghosh, P. ; Chadha, S. C. ; [et al.]

New York : Wiley-Blackwell

Die Makromolekulare Chemie 97 (1966), S. 202-208

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ISSN: 0025-116X

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: An Polymethylmethacrylaten, durch Redoxinitiierung in wäßriger Lösung dargestellt, wurden kolorimetrische Endgruppenbestimmungen durchgeführt. Die Redoxsysteme bestanden aus einer Sulfoxygruppe, HSO3-, SO2-3, S2O2-3, S2O2-4 oder S2O2-5 als Reduktionsmittel und einem der folgenden Aktivatoren: (a) Metallionen: Cu2+, Fe3+ und Ag+; (b) Kaliumchlorat und -bromat; (c) Wasserstoffperoxid und (d) Sauerstoff.Als Endgruppen werden im Falle (a) und (b) nur hydrolysebeständige Sulfoxygruppen eingebaut, bei (c) und (d) sowohl Sulfoxy- als auch Hydroxylgruppen.

Notes: Poly(methyl methacrylate) samples obtained by aqueous redox initiation with reducing sulfoxy compounds such as HSO3-, SO2-3, S2O2-3, S2O2-4, and S2O2-5 in conjunction with different activators are analysed for endgroup content by the application of dye techniques, and limiting conditions for polymerization are reported in specific cases. Activators used are: (a) metal ions such as Cu2+, Fe3+, and Ag+ ion; (b) KCIO3 and KBrO3; (c) H2O2, and (d) oxygen. Endgroups incorporated are only nonhydrolysable sulfoxy in case of (a) and (b), and both nonhydrolysable sulfoxy and hydroxyl in case of (c) and (d).

Additional Material: 3 Tab.