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  • 11
    Electronic Resource
    Electronic Resource
    Schweizer Komitee für Optik (1948)
    Springer
    Cellular and molecular life sciences 4 (1948), S. 283-283 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02164415
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  • 12
    Electronic Resource
    Electronic Resource
    Cell wall polymers in Archaea (Archaebacteria) (1998)
    Springer
    Cellular and molecular life sciences 54 (1998), S. 305-308 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Archaea (Archaebacteria); cell walls; pseudomurein; methanochondroitin; glutaminylglycan; S-layers; chemical structure; biosynthesis; antibiotics; evolution.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The distribution of the various cell wall and cell envelope (S-layer) polymers among the main lineages of the domain Archaea (Archaebacteria) and the chemical composition and primary structure of polymers forming rigid cell wall sacculi is described. Differences between bacteria and archaea in their sensitivity to antibiotics which inhibit cell wall synthesis in bacteria are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050156
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  • 13
    Electronic Resource
    Electronic Resource
    Strukturierte Abbildung radiologischer Leistungen im Kontext eines Krankenhausinformationssystems Bietet der DICOM-Standard hierfür die notwendigen Voraussetzungen? (1998)
    Springer
    Der Radiologe 38 (1998), S. 872-882 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Datenmodell ; DICOM ; Systemintegration ; Key words Data model ; DICOM ; System integration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Problem: The data model given in the DICOM standard is examined unter the aspect of system integration. Semantic properties of the IODs (information object definitions) and their relationships are investigated. Method: Starting from the entities defined in Part 3 of the DICOM standard, we explored how the classes defined there can be integrated into a common data model of the electronic patient record implemented by the HIS (Hospital Information System). Based on the IODs we investigated the definitions and semantics of entities being relevant for structured recording of image data. Results: Because semantic definitions are incomplete, a proposal is made for the core domain of structured radiologic service recording. Its definition of semantics goes beyond the application domain of radiologic imaging to avoid structural conflicts during HIS/ RIS/PACS integration. Differentiation between treatment and billing provides an independent temporal mapping of services concerning medical and billing aspects. Two groups of radiologic services are distinguished: radiologic imaging and additional services. Conclusion: The incomplete definition of IOD semantics leads to potential conflicts during system integration. Complete covering of this topic is necessary for implementation of the electronic patient record.
    Notes: Zusammenfassung Hintergrund: Das im DICOM-Standard vorgegebene Datenmodell wird unter dem Aspekt der Systemintegration betrachtet. Hierbei werden Semantik und Beziehungen innerhalb der Hierarchie der IODs (Information Object Definitions) untersucht. Methodik: Ausgehend von dem im DICOM-Standard (Teil 3) definierten Entitäten wurde überprüft, wie die dort definierten Klassen in ein gemeinsames Datenmodell der im KIS (Krankenhaus Informationssystem) implementieren elektronischen Patientenakte zu integrieren sind. Anhand der IOD untersuchten wir, wie die für die strukturierte Ablage von Bildinformationen relevanten Entitäten definiert sind und ob deren Semantik adäquat ist. Ergebnisse: Da die Semantik nicht eindeutig festgelegt ist, wird für den Kernbereich der radiologischen Leistungserfassung ein Vorschlag zur Strukturierung der Daten unterbreitet. Dieser geht in der Definition der Semantik über den Anwendungsbereich der Bildgebung hinaus, um strukturelle Konflikte bei der KIS/RIS/PACS-Integration zu vermeiden. Durch die Unterscheidung in Behandlungs- und Abrechnungsfall wird die zeitliche Zuordnung der erbrachten Leistungen unter medizinischen und abrechnungsrelevanten Gesichtspunkten gewährleistet. Radiologische Leistungen werden in bildgebende Untersuchungen und Zusatzleistungen unterteilt. Schlußfolgerungen: Durch fehlende Angaben zur Semantik der im DICOM-Standard definierten Entitäten ergeben sich potentielle Konflikte im Rahmen der Systemintegration. Die Behandlung des Themas ist im Hinblick auf die Implementierung der elektronischen Krankenakte notwendig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050437
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  • 14
    Electronic Resource
    Electronic Resource
    Differential enumeration and in situ localization of microorganisms in the hindgut of the lower termite Mastotermes darwiniensis by hybridization with rRNA-targeted probes (1999)
    Springer
    Archives of microbiology 172 (1999), S. 407-416 
    Details
    ISSN: 1432-072X
    Keywords: Key words Freeze sectioning ; Fluorescent ¶oligonucleotide probes ; In situ hybridization ; Intestinal microorganisms ; Mastotermes darwiniensis ; Oxygen microsensors ; rRNA ; Termites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We examined the abundance and spatial distribution of major phylogenetic groups of the domain Bacteria in hindguts of the Australian lower termite Mastotermes darwiniensis by using in situ hybridization with group-specific, fluorescently labeled, rRNA-targeted oligonucleotide probes. Between 32.0 ± 7.2% and 52.3 ± 8.2% of the DAPI-stained cells in different hindgut fractions were detected with probe EUB338, specific for members of the domain Bacteria. About 85% of the prokaryotic cells were associated with the flagellates of the thin-walled anterior region (P3a) and the thick wall of the posterior region (P3b/P4) of the hindgut, as shown by DAPI staining. At most, half of the EUB338-detected cells hybridized with one of the other probes that targeted a smaller assemblage within the bacterial domain. In most fractions, cells were found in varying numbers with probe ALF1b, which targeted members of the α-Proteobacteria, whereas substantial amounts of sulfate-reducing bacteria, gram-positive bacteria with a high DNA G+C content and members of the Cytophaga-Flavobacterium cluster of the Cytophaga-Flavobacterium-Bacteroides (CFB) phylum could be detected only in the wall fraction of P3b/P4. This clearly indicates that the hindgut microhabitats differ in the composition of their microbial community. In situ hybridization of cryosections through the hindgut showed only low numbers of bacteria attached to the P3a wall. In contrast, the wall of P3b was densely colonized by rod- and coccus-shaped bacteria, which could be assigned to the Cytophaga-Flavobacterium cluster of the CFB phylum and to the group of gram-positive bacteria with a high DNA G+C content, respectively. Oxygen concentration profiles determined with microelectrodes revealed steep oxygen gradients both in P3a and P3b. Oxygen was consumed within 100 μm below the gut surface, and anoxic conditions prevailed in the central portions of both gut regions, indicating that oxygen consumption in the hindgut does not depend on the presence of a biofilm on the hindgut wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050778
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  • 15
    Electronic Resource
    Electronic Resource
    Anforderungsdefinition und -spezifikation für PAC-Systeme (Picture Archiving and Communications System) Ein Leistungsverzeichnis in Anlehnung an den Standard„IEEE Recommended Practice for Software Requirements Specifications” (1999)
    Springer
    Der Radiologe 39 (1999), S. 269-275 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter PACS ; Anforderungen ; Checkliste ; Key words PACS ; Requirements ; Checklist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Problem: The formulation of requirements is necessary to control the goals of a PACS project. Furthermore, in this way, the scope of functionality necessary to support radiological working processes becomes clear. Method: Definitions of requirements and specification are formulated independently of systems according to the IEEE standard ’’Recommended Practice for Software Requirements Specifications’’. Definitions are given in the Request for Information, specifications in the Request for Proposal. Functional and non-functional requirements are distinguished. The solutions are rated with respect to scope, appropriateness and quality of implementation. Results: A PACS checklist was created according to the methods described above. It is published on the homepage of the ’’Arbeitsgemeinschaft Informationstechnologie’’ (AGIT) within the ’’Deutsche Röntgengesellschaft’’ (DRG) (http://www.uni-marburg. de/mzr/agit). Conclusion: The checklist provides a discussion forum which should contribute to an agreement on accepted basic PACS functionalities.
    Notes: Zusammenfassung Hintergrund: Die Formulierung von Anforderung bildet die Grundlage für die Kontrolle der Zielvorgaben in einem PACS-Projekt. Sie soll ferner Art und Umfang der PACS-Funktionalität klären, die zur Unterstützung radiologischer Arbeitsabläufe notwendig ist. Methodik: Anforderungsdefinitionen und -spezifikationen werden in Anlehnung an den IEEE-Standard „Recommended Practice for Software Requirements Specifications” systemunabhängig formuliert. Definitionen werden im Request for Information (Anforderung eines Lösungsvorschlags), Spezifikationen im Request for Proposal (Angebotsanforderung) festgelegt, wobei zwischen funktionalen und nicht-funktionalen Anforderungen unterschieden wird. Bewertet werden Umfang, Angemessenheit und Qualität der angebotenen Systemlösungen. Ergebnisse: Es wurde eine PACS-Checkliste erstellt, die die genannten Grundsätze berücksichtigt und auf den Webseiten der Arbeitsgemeinschaft Informationstechnologie (AGIT) der Deutschen Röntgengesellschaft veröffentlicht wird (http://www.uni-marburg. de/mzr/agit). Schlußfolgerungen: Mit der Checkliste wird ein Diskussionsforum angeboten, das zur Festlegung einer akzeptierten PACS-Basisfunktionalität beitragen soll.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050508
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  • 16
    Electronic Resource
    Electronic Resource
    $\mu\rightarrow e\gamma$ decay in the left-right supersymmetric model (1999)
    Springer
    The European physical journal 7 (1999), S. 135-139 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We calculate the dipole amplitude for the decay $\mu\rightarrow e\gamma$ and related processes in the left-right supersymmetric model when parity breaking occurs at a considerably large scale. The low-energy flavor violation in the model originates either from the nonvanishing remnants of the left-right symmetry in the slepton mass matrix or from the direct flavor changing lepton-slepton-neutralino interaction. The result is found to be large and already accessible with current experimental accuracy for supersymmetric masses not far above the electroweak scale. It also provides nontrivial constraints on the lepton mixing in the model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100529800966
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  • 17
    Electronic Resource
    Electronic Resource
    Progesterone as a neurosteroid: Actions within the nervous system (1996)
    Springer
    Cellular and molecular neurobiology 16 (1996), S. 143-154 
    Details
    ISSN: 1573-6830
    Keywords: steroids ; neurosteroids ; progesterone ; estradiol ; nerve regeneration ; myelin ; Schwann cells ; oligodendrocytes ; astrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Some progesterone is synthesized within both the central and the peripheral nervous systems, where it regulates neurotransmission and important glial functions, such as the formation of myelin. Progesterone can thus be designated a “neurosteroid.” 2. Steroids act not only on the brain, but also on peripheral nerves, which offer many advantages to study the biological significance of locally produced neurosteroids: their remarkable plasticity and regenerative capacity and their relatively simple structure. 3. By using the regenerating mouse sciatic nerve as a model, we have shown that progesterone synthesized by rat Schwann cells promotes the formation of new myelin sheaths. Progesterone also increases the number of myelinated axons when added at a low concentration to cocultures of Schwann cells and sensory neurons. 4. These findings show a function on myelination for locally produced progesterone and suggest a new pharmacological approach of myelin repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088173
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  • 18
    Electronic Resource
    Electronic Resource
    Isolated Renal Aspergillus Abscess in an AIDS Patient with a Normal CD4+ Cell Count on Highly Active Antiretroviral Therapy (1999)
    Springer
    European journal of clinical microbiology & infectious diseases 18 (1999), S. 137-141 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Isolated renal Aspergillus abscess is a very rare complication of HIV infection. It usually occurs in patients with severe immune deficiency. The case of a 29-year-old HIV-infected homosexual male, a nonintravenous drug abuser, who developed a right renal Aspergillus abscess despite normalization of the CD4+ cell count after highly active antiretroviral treatment is described. When antimicrobial treatment failed (amphotericin B followed by itraconazole), he was cured by right nephrectomy and remains in good health 3 months later with no recurrence. In cases of Aspergillus renal abscess in HIV-infected patients, surgery is the treatment of choice, especially in the current era of highly active antiretroviral therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050242
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  • 19
    Electronic Resource
    Electronic Resource
    Zur Chemie des Streptomycins (1949)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 61 (1949), S. 6-11 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19490610103
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  • 20
    Electronic Resource
    Electronic Resource
    Trennung von teilweise racemisiertem Phenylalanin in optisch aktive und optisch inaktive Form (1948)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 31 (1948), S. 183-188 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird ein Verfahren zur Trennung von optisch aktivem und optisch inaktivem Phenylalanin beschrieben, darauf beruhend, dass das Salz des optisch inaktiven Phenylalanins rnit 4′-Chlor-2-nitrodiphenylamin- 4-sulfosäure gegenüber den Salzen der optisch aktiven Komponenten mit dieser Sulfosäure in Wasser genügend grosse Löslichkeitsdifferenzen aufweist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19480310139
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