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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Since we have recently shown that the β2-adrenoreceptor (β2-AR) expression of selected regions of the hair follicle (HF) epithelium as well as the number of adrenergic nerve fibers in murine skin change in a hair cycle-dependent manner, this has raised the possibility that adrenergic nerves may exert “trophic” functions during HF cycling. To further explore this concept, we have investigated the effect of neuro-pharmacological manipulations on hair growth (anagen) induction in quiescent telogen mouse skin in vivo. Here, we demonstrate that subcutaneous injections of the noradrenaline (NA)-depleting agent guanethidine, or of the neurotoxin 6-hydroxydopaine, but not of the β2-AR agonist isoproterenol induce a premature onset of anagen in the lower back skin of C57BL/6 mice. On day 20 after the start of treatment, more than 80% of the guanethidine-treated mice and ca. 65% of the 6-hydroxydopamine-treated (6-OHDA) mice exhibited premature skin darkening and hair growth at the site of drug application, whereas less than one-third of all control animals showed macroscopic signs of anagen developent. This was confirmed by histology, demonstrating mature anagen VI HFs only at the immediate site of treatment with guanethidine of 6-OHDA as opposed to resting telogen HFs in the neighboring untreated skin area. This observation further supports the concept that sympathetic nerves are intimately involved in hair growth control and invites one to explore the neuro-pharmacological manipulation of piloneural interactions as a novel therapeutic strategy for the management of hair growth disorders.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 25 (1995), S. 642-650 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract To better understand the electrochemistry of nickel electrowinning from nickel chloride solutions at the cathode-electrolyte interface, the cathode surface pH was measured using a flat-bottom combination glass pH electrode and a 500 mesh nickel-plated gold gauze as cathode. The cell was a modification of that designed by Romankiw and coworkers. The pH electrode was positioned at the back of, and in direct contact with, the gauze cathode. As expected, the cathode surface pH was always higher than the pH in the bulk electrolyte, and if the current density was sufficiently large, it could cause the precipitation of insoluble Ni(OH)2(5) on the cathode surface. Lower bulk pH, higher nickel concentration, higher temperature, and the additions of H3BO3 and NH4Cl effectively suppressed the rise of the cathode surface pH. The results provide further evidence of the buffering action of H3BO3 and NH4Cl and of the enhancement of nickel deposition by H3BO3. At current densities less than 240 A m−2 additions of NaCl and Na2SO4 suppressed the rise of the cathode surface pH but to a much smaller degree.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Social psychiatry and psychiatric epidemiology 34 (1999), S. 507-512 
    ISSN: 1433-9285
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: This study investigated whether, similarly to schizophrenia, there is an increased rate of schizotypy among African-Caribbeans in the general population compared with white people in the UK. Since social adversity has been associated with schizophrenia in a number of studies, social class as well as ethnicity was explored. In addition, any differences between the groups in neurotic pathology were investigated. Methods: Four groups of 12 participants (African-Caribbean, working-class; African-Caribbean, middle-class; white, middle-class; white, working-class) were interviewed using The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), The Peters et al. Delusions Inventory (PDI), The Delusions-Symptoms-State-Inventory (DSSI) and The Hospital Anxiety and Depression Scale (HADS). Results: As predicted, African-Caribbean participants scored higher than the white participants on the PDI. There was a significant interaction between ethnicity and class, with African-Caribbean, working-class participants scoring higher than the other three groups on the PDI as well as on the DSSI. There was an unexpected effect of class, with the middle-classes scoring higher than the working-classes on the O-LIFE category of `impulsive non-conformity'. Conclusions: These findings suggest that it is delusional ideation specifically, rather than general schizotypy, that is higher in the African-Caribbean population. However, whether this is a reflection of their social reality or their psychosis proneness is unclear. Furthermore, the results suggest that class is a significant factor in the expression of delusional ideation in African-Caribbeans.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-069X
    Keywords: Key words Mast cell ; Nerve fibers ; Avidin ; Neuropeptides ; Skin ; Hair cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling the nerve fibers. For this purpose, we developed the following triple-staining technique. After paraformaldehyde-picric acid perfusion fixation, cryostat sections of back skin from C57BL/6 mice were incubated with a primary rat monoclonal antibody to substance P (SP), followed by incubation with a secondary goat-anti-rat TRITC-conjugated IgG. A rabbit antiserum to CGRP was then applied, followed by a secondary goat-anti-rabbit FITC-conjugated IgG. MCs were visualized by incubation with AMCA-labelled avidin, or (for a more convenient quantification of close MC-nerve fiber contacts) with a mixture of TRITC- and FITC-labelled avidins. Using this simple, novel covisualization method, we were able to show that MC-nerve associations in mouse skin are, contrary to previous suggestions, highly selective for nerve fiber types, and that these interactions are regulated in a hair cycle-dependent manner: in telogen and early anagen skin, MCs preferentially contacted CGRP-immunoreactive (IR) or SP/CGRP-IR double-labelled nerve fibers. Compared with telogen values, there was a significant increase in the number of close contacts between MCs and tyrosine hydroxylase-IR fibers during late anagen, and between MCs and peptide histidine-methionine-IR and choline acetyl transferase-IR fibers during catagen.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 290 (1998), S. 574-578 
    ISSN: 1432-069X
    Keywords: Key words Hair growth ; C57BL/6 mice ; Denervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuropeptides produced, stored and secreted by the unusually dense sensory and autonomic innervation of hair follicles (HFs) can induce hair growth (anagen) and may be involved in hair growth control. To test the role of follicle innervation of HF cycling in vivo, we generated innervation-deficient HFs by unilateral surgical denervation of a defined region of back skin in C57BL/6 mice and assessed its effect on spontaneous and induced anagen development. Successful denervation was demonstrated by the absence of PGP 9.5+ or tyrosine hydroxylase+ nerves and nerve-associated neuropeptides (substance P, CGRP). By quantitative histomorphometry, no significant difference in spontaneous or cyclosporin A-induced anagen development could be detected between sham-operated control skin and denervated skin. Only after hair growth induction by depilation, a discrete, marginally significant retardation of anagen development was apparent in denervated HFs. Thus, even though cutaneous nerves may exert a minor modulatory role in depilation-induced hair growth, they are not essential for normal murine anagen development.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 54 (1998), S. 1102-1108 
    ISSN: 1420-9071
    Keywords: Key words. Prolactin; growth hormone; insulin-like growth factor; AIDS; ageing; pituitary adenoma; acromegaly.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Prolactin (PRL) and growth hormone (GH) qualify as lymphoid growth and differentiation factors. Yet, long-standing hyper- or hyposecretion of PRL or GH does not induce any significant alteration of the immune system. Subclinical changes in laboratory parameters (such as chemotaxis or phagocytosis by granulocytes or macrophages or natural killer cell activity) have been reported in some of these conditions. The GH-insulin-like growth factor (IGF)-I axis is dysregulated in ageing, in catabolic states and in critical illness. Immune parameters, such as infection rate, are being monitored during clinical trials with GH or IGF-I. Hyperprolactinaemia may play an aggravating role in systemic lupus erythematosus, in autoimmune thyroiditis and in other autoimmune diseases. The patient may benefit from increased alertness about interactions between the endocrine and immune systems.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Lung 54 (1923), S. 431-439 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 17 (1998), S. 591-592 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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