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  • 1
    ISSN: 1432-1238
    Keywords: Weaning CPAP ; BiPAP ; Extravascular lung water ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the effects of continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP) on extravascular lung water during weaning from mechanical ventilation in patients following coronary artery bypass grafting. Design Prospective, randomized clinical study. Setting Intensive care unit at a university hospital. Patients Seventy-five patients following coronary artery bypass grafting. Interventions After extubation of the trachea, patients were treated for 30 min with CPAP via face mask (n=25), with nasal BiPAP (n=25), or with oxygen administration via nasal cannula combined with routine chest physiotherapy (RCP) for 10 min (n=25). Measurements and results Extravascular lung water (EVLW), pulmonary blood volume index (PBVI) and cardiac index (CI) were obtained during mechanical ventilation (T1), T-piece breathing (T2), interventions (T3), spontaneous breathing 60 min (T4) and 90 min (T5) after extubation of the trachea using a combined dye-thermal dilution method. Changing from mechanical ventilation to T-piece breathing did not show any significant differences in EVLW between the three groups, but a significant increase in PBVI from 155±5 ml/m2 to 170±4 ml/m2 could be observed in all groups (p〈0.05). After extubation of the trachea and treatment with BiPAP, PBVI decreased significantly to 134±6 ml/m2 (p〈0.05). After treatment with CPAP or BiPAP, EVLW did not change significantly in these groups (5.5±0.3 ml/kg vs 5.0±0.4 ml/kg and 5.1±0.4 ml/kg vs 5.7±0.4 ml/kg). In the RCP-treated group, however, EVLW increased significantly from 5.8±0.3 ml/kg to 7.1±0.4 ml/kg (p〈0.05). Sixty and 90 min after extubation, EVLW stayed at a significantly higher level in the RCP-treated group (7.5±0.5 ml/kg and 7.4±0.5 ml/kg) than in the CPAP-(5.6±0.3 ml/kg and 5.9±0.4 ml/kg). No significant differences in CI could be observed within the three groups during the time period from mechanical ventilation to 90 min after extubation of the trachea. Conclusions Mask CPAP and nasal BiPAP after extubation of the trachea prevent the increase in extravascular lung water during weaning from mechanical ventilation. This effect is seen for at least 1 h after the discontinuation of CPAP or BiPAP treatment. Fuether studies have to evaluate the clinical relavance of this phenomenon.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Key words Weaning ; CPAP ; BiPAP ; Extravascular lung water ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the effects of continuous positive airway pressure (CPAP) and bi-level positive airway pressure (BiPAP) on extravascular lung water during weaning from mechanical ventilation in patients following coronary artery bypass grafting. Design; Prospective, randomized clinical study. Setting; Intensive care unit at a university hospital. Patients; Seventy-five patients following coronary artery bypass grafting. Interventions; After extubation of the trachea, patients were treated for 30 min with CPAP via face mask (n=25), with nasal BiPAP (n=25), or with oxygen administration via nasal cannula combined with routine chest physiotherapy (RCP) for 10 min (n=25). Measurements and results: Extravascular lung water (EVLW), pulmonary blood volume index (PBVI) and cardiac index (CI) were obtained during mechanical ventilation (T1), T-piece breathing (T2), interventions (T3), spontaneous breathing 60 min (T4) and 90 min (T5) after extubation of the trachea using a combined dye-thermal dilution method. Changing from mechanical ventilation to T-piece breathing did not show any significant differences in EVLW between the three groups, but a significant increase in PBVI from 155±5 ml/m2 to 170±4 ml/m2 could be observed in all groups (p〈0.05). After extubation of the trachea and treatment with BiPAP, PBVI decreased significantly to 134±6 ml/m2 (p〈0.05). After treatment with CPAP or BiPAP, EVLW did not change significantly in these groups (5.5±0.3 ml/kg vs 5.0±0.4 ml/kg and 5.1±0.4 ml/kg vs 5.7±0.4 ml/kg). In the RCP-treated group, however, EVLW increased significantly from 5.8±0.3 ml/kg to 7.1±0.4 ml/kg (p〈0.05). Sixty and 90 min after extubation, EVLW stayed at a significantly higher level in the RCP-treated group (7.5±0.5 ml/kg and 7.4±0.5 ml/kg) than in the CPAP-(5.6±0.3 ml/kg and 5.9±0.4 ml/kg) or BiPAP-treated groups (5.2±0.4 ml/kg and 5.2±0.4 ml/kg). No significant differences in CI could be observed within the three groups during the time period from mechanical ventilation to 90 min after extubation of the trachea. Conclusions: Mask CPAP and nasal BiPAP after extubation of the trachea prevent the increase in extravascular lung water during x weaning from mechanical ventilation. This effect is seen for at least 1 h after the discontinuation of CPAP or BiPAP treatment.Further studies have to evaluate the clinical relevance of this phenomenon.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Deactivation Behaviour of Arenes and Heteroarenes. XXXVI. The Solvent and Temperature Dependence of Deactivation Behaviour of 9, 9′-Bis(acridizinium-yl) at High ConcentrationAt room temperature the geometrical structure of the fluoresceing singlet state of 9, 9′-bis(acridizinium-yl) is determined by the solvent. In solvents of the type A (water, methanol, acetonitril) a plain S1-state emits, in the case of the solvent type B (ethanol, propanol-(2)) the S1-state is twisted. Both excited states have different emission spectroscopical properties.At high concentration (c ≥ 10-4 mol l-1) in the case of the solvent type B a new emission band is observed, and the monomer emission is quenched. This new band is interpreted as a fluorescence from a molecular associate in the excited state. The intensity of this associate band is increasing with decreasing temperature. It is shown that this band is the result of molecular association in the ground state. From the photochemical irradiation it follows that only in the case of the solvent type B a photocycloaddition is possible. The plain S1-state does not react.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 339 (1997), S. 482-484 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On the Mass Spectrometric Characterization of ω-Chloralkylphenylphosphines
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 2 (1955), S. 196-202 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Viskosität von Lösungen des sogenannten KURROLschen Kaliumsalzes (KPO3)x ist nicht nur abhängig von den Herstellungsbedingungen, insbesondere der Temperaturführung, sowie vom genauen Molverhältnis K2O:P2O5 des Ausgangsmaterials und  -  hierdurch bedingt  -  vom Grad der Vernetzung der Polyphosphatketten, sondern auch von der Anwesenheit geringer Verunreinigungen. So läßt sich der höchstviskose Typ nur aus völlig arsenfreien Ausgangsprodukten darstellen. Arsen (V) wird in die Polyphosphatanionen eingebaut. Beim Behandeln mit Wasser hydrolysiert Arsen (V) momentan als Orthoarsenat heraus, wodurch Kettenbruch eintritt, und man erhält Lösungen von geringerer Viskosität, was schon merklich ist, wenn auf 106 Atome P 1 Atom Arsen kommt. Hieraus wird geschlossen, daß der durchschnittliche Kondensationsgrad der Polyphosphatanionen im höchstviskosen KURROLschen Kaliumsalz mindestens von der Größenordnung 106 sein muß.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 155 (1940), S. 129-162 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 313 (1971), S. 956-968 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Addition verschiedener elektrophiler Agenzien an ω-Methoxyolefine wurde untersucht, um Aufschluß über eine Methoxygruppenbeteiligung zu erhalten. Eine derartige Beteiligung konnte bei der Addition von Chlor und Brom an 5-Methoxypenten-(1) nachgewiesen werden; hier entstehen zu 10-15% die entsprechenden 2-Halogenmethyltetrahydrofurane, und zu 50-60% tritt Umlagerung unter Verschiebung der Methoxygruppe ein. Die Addition von Chlor oder Brom an 6-Methoxyhexen-(1) liefert zu 15-20% die entsprechenden 2-Halogenmethyltetrahydropyrane, eine Methoxylgruppenwanderung ist nicht nachweisbar. Die Reaktion von Chlor oder Brom mit 4-Methoxybuten-(1) und mit 7-Methoxyhepten-(1) liefert ausschließlich 1, 2-Additionsprodukte.Bei der Anlagerung von Chlor an Allyl-methyl-äther erhält man außer 73% 2,3-Dichlor-1-methoxypropan infolge nebenher ablaufender Dreikomponentenreaktionen 12% 1,2,3-Trichlorpropan, 7% 1,3-Dimethoxy-2-chlorpropan und 8% 1, 2-Dimethoxy-3-chlorpropan. Bei der Addition von 2,4-Dinitrophenylsulfenylchlorid und von Quecksilberacetat an ω-Methoxyolefine tritt weder Umlagerung noch Ringschluß ein. Mit 2, 4-Dinitrophenylsulfenylchlorid entstehen nebeneinander Markownikow- und anti-Markownikow-Produkte, der Anteil des Markownikow-Produktes steigt mit wachsender Kettenlänge vom Allyl-methyl-äther bis zum 7-Methoxyhepten-(1).
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 312 (1970), S. 622-634 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Elektrophile Additionen an Cyclooctadien-(1,5) können unter transannularer Beteiligung der zweiten Doppelbindung zu Bicylo [3,3,0] octanderivaten führen. Diese entstehen allerdings nur, wenn starke Protonsäuren, starke Lewis-Säuren oder Chlor als elektrophile Agenzien angewandt werden.Elektrophile Additionen in Methanol oder in Essigsäure als Lösungsmittel führen im ersten Reaktionsschritt vorzugsweise zu nicht umgelagerten Dreikomponentenprodukten; der elektrophile Angriff auf die zweite Doppelbindung erfolgt dann unter transannularer Beteiligung der OMe- oder OAc-Gruppe und führt zu Gemischen aus 9-Oxa-bicyclo[3,3,1]-nonan- und 9-Oxa-bicyclo[4,2,1]nonan-Derivaten.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 319 (1977), S. 775-784 
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Chlorination of PentaneThe kinetics of the chlorination of pentane were studied and the concentration course of the mono- and dichlorpentanes calculated with the aid of an analog-computer. The relative reactivities of different C—H-bonds were determined from the rate constants. The structure of the diastereomeres formed is discussed.
    Notes: Die Kinetik der Pentanchlorierung wurde untersucht und der Konzentrationsverlauf der Mono- und Dichlorpentane am Analogrechner nachgebildet. Aus den erhaltenen Geschwindigkeitskonstanten wurden C—H-Reaktivitäten ermittelt. Die Struktur der auftretenden Diastereomeren wird diskutiert.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Geschwindigkeiten der Homodimerisierung von Cyclopentadien, Isopren, trans-Piperylen und cis-Piperylen verhalten sich bei 150° wie 1000: 1,3 : 0,9 : 0,09. Isopren liefert vorwiegend, trans-Piperylen ausschließlich Sechsringdimere; aus cis-Piperylen entstehen hauptsächlich Vierringdimere.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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