Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ergebnis der Prüfung eines Pipetten-Sicherheitsaufsatzes (1952)
    Springer
    Medical microbiology and immunology 136 (1952), S. 85-87 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird der neue Pipetten-Sicherheitsaufsatz des Ing. K.Kammer beschrieben, der in den Laboratorien des Hygiene-Instituts Freiburg eingehend geprüft wurde und sich insbesondere wegen seiner einfachen Handhabung und guten Sterilisationsmöglichkeit als Sicherheitsvorrichtung beim Pipettieren und beim Saughebern gut bewährt hat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02152529
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of continuous (CPAP) and bi-level positive airway pressure (BiPAP) on extravascular lung water after extubation of the trachea in patients following coronary artery bypass grafting (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1345-1350 
    Details
    ISSN: 1432-1238
    Keywords: Key words Weaning ; CPAP ; BiPAP ; Extravascular lung water ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the effects of continuous positive airway pressure (CPAP) and bi-level positive airway pressure (BiPAP) on extravascular lung water during weaning from mechanical ventilation in patients following coronary artery bypass grafting. Design; Prospective, randomized clinical study. Setting; Intensive care unit at a university hospital. Patients; Seventy-five patients following coronary artery bypass grafting. Interventions; After extubation of the trachea, patients were treated for 30 min with CPAP via face mask (n=25), with nasal BiPAP (n=25), or with oxygen administration via nasal cannula combined with routine chest physiotherapy (RCP) for 10 min (n=25). Measurements and results: Extravascular lung water (EVLW), pulmonary blood volume index (PBVI) and cardiac index (CI) were obtained during mechanical ventilation (T1), T-piece breathing (T2), interventions (T3), spontaneous breathing 60 min (T4) and 90 min (T5) after extubation of the trachea using a combined dye-thermal dilution method. Changing from mechanical ventilation to T-piece breathing did not show any significant differences in EVLW between the three groups, but a significant increase in PBVI from 155±5 ml/m2 to 170±4 ml/m2 could be observed in all groups (p〈0.05). After extubation of the trachea and treatment with BiPAP, PBVI decreased significantly to 134±6 ml/m2 (p〈0.05). After treatment with CPAP or BiPAP, EVLW did not change significantly in these groups (5.5±0.3 ml/kg vs 5.0±0.4 ml/kg and 5.1±0.4 ml/kg vs 5.7±0.4 ml/kg). In the RCP-treated group, however, EVLW increased significantly from 5.8±0.3 ml/kg to 7.1±0.4 ml/kg (p〈0.05). Sixty and 90 min after extubation, EVLW stayed at a significantly higher level in the RCP-treated group (7.5±0.5 ml/kg and 7.4±0.5 ml/kg) than in the CPAP-(5.6±0.3 ml/kg and 5.9±0.4 ml/kg) or BiPAP-treated groups (5.2±0.4 ml/kg and 5.2±0.4 ml/kg). No significant differences in CI could be observed within the three groups during the time period from mechanical ventilation to 90 min after extubation of the trachea. Conclusions: Mask CPAP and nasal BiPAP after extubation of the trachea prevent the increase in extravascular lung water during x weaning from mechanical ventilation. This effect is seen for at least 1 h after the discontinuation of CPAP or BiPAP treatment.Further studies have to evaluate the clinical relevance of this phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709549
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of continuous (CPAP) and bi-level positive airway pressure (BiPAP) on extravascular lung water after extubation of the trachea in patients following coronary artery bypass grafting (1996)
    Springer
    Intensive care medicine 22 (1996), S. 1345-1350 
    Details
    ISSN: 1432-1238
    Keywords: Weaning CPAP ; BiPAP ; Extravascular lung water ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the effects of continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP) on extravascular lung water during weaning from mechanical ventilation in patients following coronary artery bypass grafting. Design Prospective, randomized clinical study. Setting Intensive care unit at a university hospital. Patients Seventy-five patients following coronary artery bypass grafting. Interventions After extubation of the trachea, patients were treated for 30 min with CPAP via face mask (n=25), with nasal BiPAP (n=25), or with oxygen administration via nasal cannula combined with routine chest physiotherapy (RCP) for 10 min (n=25). Measurements and results Extravascular lung water (EVLW), pulmonary blood volume index (PBVI) and cardiac index (CI) were obtained during mechanical ventilation (T1), T-piece breathing (T2), interventions (T3), spontaneous breathing 60 min (T4) and 90 min (T5) after extubation of the trachea using a combined dye-thermal dilution method. Changing from mechanical ventilation to T-piece breathing did not show any significant differences in EVLW between the three groups, but a significant increase in PBVI from 155±5 ml/m2 to 170±4 ml/m2 could be observed in all groups (p〈0.05). After extubation of the trachea and treatment with BiPAP, PBVI decreased significantly to 134±6 ml/m2 (p〈0.05). After treatment with CPAP or BiPAP, EVLW did not change significantly in these groups (5.5±0.3 ml/kg vs 5.0±0.4 ml/kg and 5.1±0.4 ml/kg vs 5.7±0.4 ml/kg). In the RCP-treated group, however, EVLW increased significantly from 5.8±0.3 ml/kg to 7.1±0.4 ml/kg (p〈0.05). Sixty and 90 min after extubation, EVLW stayed at a significantly higher level in the RCP-treated group (7.5±0.5 ml/kg and 7.4±0.5 ml/kg) than in the CPAP-(5.6±0.3 ml/kg and 5.9±0.4 ml/kg). No significant differences in CI could be observed within the three groups during the time period from mechanical ventilation to 90 min after extubation of the trachea. Conclusions Mask CPAP and nasal BiPAP after extubation of the trachea prevent the increase in extravascular lung water during weaning from mechanical ventilation. This effect is seen for at least 1 h after the discontinuation of CPAP or BiPAP treatment. Fuether studies have to evaluate the clinical relavance of this phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01709549
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Molecular mechanical and quantum chemical study on the species involved in the hydrolysis of cis-diamminedichloroplatinum(II) and substituted bis(ethylenediamine)dichloroplatinum(II) complexes Part I. Reactants and products
    Amsterdam : Elsevier
    Inorganica Chimica Acta 217 (1994), S. 159-170 
    Details
    ISSN: 0020-1693
    Keywords: Ammine complexes ; Halide complexes ; Platinum complexes ; Quantum mechanical study
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-1693(93)03765-3
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Stiff-man syndrome associated with continous sufentanil administration (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 50 (1995), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1995.tb06083.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Postoperative 12-lead ECG predicts peri-operative myocardial ischaemia associated with myocardial cell damage (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peri-operative myocardial ischaemia is the single most important risk factor for an adverse cardiac outcome after non-cardiac surgery. The present study examines whether intermittent 12-lead ECG recordings can be used as an early warning tool to identify patients suffering from peri-operative myocardial ischaemia and subsequent myocardial cell damage. Fifty-five vascular surgery patients at risk for or with a history of coronary artery disease were monitored for peri-operative myocardial ischaemia using intermittent 12-lead ECG recordings taken pre-operatively and at 15 min, 20 h, 48 h, 72 h and 84 h postoperatively. The effectiveness of the 12-lead ECG was gauged by examining concordance with continuous 3-channel Holter monitoring and capturing peri-operative myocardial ischaemia by serial analyses of creatine kinase myocardial band isoenzyme and cardiac troponin T and I. The incidence of peri-operative myocardial ischaemia detected by 12-lead ECG was 44% and was identifiable in most patients (88%) 15 min after surgery. The incidence of peri-operative myocardial ischaemia detected by continuous monitoring was 53%, with the most severe episodes occurring intra-operatively and during emergence from anaesthesia. The concordance of the 12-lead method with continuous monitoring was 72%. The concordance of creatine kinase myocardial band isoenzyme activity with the 12-lead method was 71% and with Holter monitoring 57%. The concordance of mass concentration of creatine kinase myocardial band with 12-lead ECG recordings was 75%, and the corresponding value for Holter monitoring was 68%. The concordance of cardiac troponin T and I levels with the 12-lead method was 85% and 87%, respectively, and concordance with Holter monitoring was 72% and 66%, respectively. The postoperative 12-lead ECG identified peri-operative myocardial ischaemia associated with subsequent myocardial cell damage in most patients undergoing vascular surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03960.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Dichlorobis(cycloalkylamine)platinum(II) complexes structure activity relationship on the human MDA-MB-231 breast cancer cell line (1993)
    Springer
    Monatshefte für Chemie 124 (1993), S. 587-604 
    Details
    ISSN: 1434-4475
    Keywords: cis- andtrans-Dichlorobis(cycloalkylamine)platinum(II) complexes ; Antitumor activity ; MDA-MB-231 Breast cancer cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Synthese von Dichlorobis(cycloalkylamin)platin(II)-Komplexen mitcis- undtrans-ständigen Cycloalkylaminliganden [cis-PtCl2(C3H5NH2)2 biscis-PtCl2(C8H15NH2)2 (3–8) sowietrans-PtCl2(C7H13NH2)2 (9) undtrans-PtCl2(C8H15NH2)2 (10)] wird beschrieben. Eine Unterscheidung zwischencis- undtrans-Isomeren konnte mit Hilfe der1H-NMR-Spektroskopie getroffen werden. Die tumorwachstumshemmende Wirkung wurde im Langzeitversuch an der menschlichen MDA-MB-231 Brustkrebszellinie bestimmt. Die Komplexe mit kleinen Cycloalkylaminliganden (3–6) waren weniger, diejenigen mit großen Cycloalkylaminliganden vergleichbar (7) oder besser (8) wirksam als Cisplatin. Überraschenderweise waren diecis/trans Isomeren7/9 und8/10 gleich aktiv. Sämtliche Cycloalkylaminliganden waren unwirksam. IR-spektroskopische Untersuchungen zeigen, daß die Größe des Cycloalkylaminliganden zu keiner signifikanten Veränderung der Pt-Cl Bindungsstärke führt. Es wird angenommen, daß die deutlich stärkere Antitumoraktivität der höheren Homologen7–10 nicht auf eine schnellere Reaktion mit Bionucleophilen wie der DNA zurückzuführen ist. Eine mögliche Erklärung der hohen Aktivität von7–10 liegt in der starken Lipophilie der Komplexe. Diese Annahme wird durch Cytotoxizitätstests an stationären Kulturen gestützt.
    Notes: Summary The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes withcis andtrans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 tocis-PtCl2(C8H15NH2)2 (3–8) andtrans-PtCl2(C7H13NH2)2 (9) andtrans-PtCl2(C8H15NH2)2 (10)] are described. The distinction betweencis andtrans isomers was achieved by1H-NMR spectroscopy. The antitumor activity was determined on the cell proliferation of the human MDA-MB-231 breast cancer cell line during long-term drug exposure. The complexes with small cycloalkylamine ligands (3–6) were inferior, those with large cycloalkylamine ligands were comparable (7) or superior (8) to cisplatin. Surprisingly, thecis/trans isomers7/9 and8/10 were equally active. All cycloalkylamine ligands were inactive. IR-spectroscopic studies showed that the size of the cycloalkylamine ring does not lead to significant differences in the Pt-Cl binding strength. Therefore it is assumed that the markedly stronger antitumor activity of the higher homologues,7–10, is not the result of a faster reaction with bionucleophils such as DNA. A possible explanation of the high activity of7–10 is the strong lipophilicity of the complexes. This assumption was confirmed by toxicity tests against confluent cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00819526
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Molecular mechanical and quantum chemical study of the species involved in the hydrolysis ofcis-diamminedichloroplatinum(II) and substitutedbis(ethylenediamine)-dichloroplatinum(II) complexes II. Simulated transition states (1997)
    Springer
    Monatshefte für Chemie 128 (1997), S. 443-474 
    Details
    ISSN: 1434-4475
    Keywords: Platinum coordination compounds ; Antitumor activity ; Molecular modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung cis-Diammindichlorplatin(II) (Cisplatin) und seine substituierten Ethylendiaminderivatecis-PtCl2(R 2 en) (en=Ethylendiamin,R=H, Ph, 2-, 3- und 4-PhOH) wurden im Hinblick auf mögliche Strukturen der hypothetischen Übergangszustandkomplexe (TSC) der hydrolytische SN2-Reaktion (Substitution eines Cl-Atoms durch H2O) untersucht.TSCs mit trigonalbipyramidalen (TBP) und quadratisch-pyramidalen (SP) Geometrien (Koordinationszahl 5) wurden mit molekularmechanischen (MM) und Extended-Hückel-Methoden (EH) behandelt.EH- undMM-Energien sowie entropische Faktoren weisen für Cisplatin auf eine trigonale Bipyramide mit NH3 und Cl in axialen Positionen als bevorzugteTSC-Geometrie hin, während für Komplexe miten-LigandenSP-Geometrien mit Cl in der apicalen Position energetisch begünstigt sind. Da die berechnetenEH- undMM- Energien fürTBP- undSP-Geometrien sehr ähnlich sind, spielen möglicherweiseTBP-SP-Umwandlungen eine wesentliche Rolle bei der Bildung derTSCs. Zur Verbesserung der Unterscheidung wurden für dieMM-optimierten Geometrien die Verschiebungsvektoren (DV) bezüglich D3h (TBP) und C4v (SP) berechnet. Daraus resultierte erneut die trigonale Bipyramide mit NH3 und Cl in den axialen Positionen als das am wenigsten gespannte Konformere; des weiteren konnten mit dieser Methode die Kombinationen der Verschiebungskoordinaten erhalten werden, die für die Ausbildung derTSC-Geometrie verantwortlich sind.
    Notes: Summary cis-Diamminedichloroplatinum(II) (cisplatin) and its substituted ethylenediamine derivativescis-PtCl2(R 2 en) (en=ethylenediamine,R=H,Ph,2-,3-, and 4-PhOH) have been investigated with respect to the possible structures of the hypothetical Transition State Complexes (TSC) of the hydrolytic SN2 reaction in which one Cl is replaced by H2O.TSCs withtrigonal bipyramid (TBP) andsquare pyramid (SP) geometry (coordination number 5), have been studied by Molecular Mechanics (MM) and ExtendedHückel (EH) methods. TheEH andMM energies as well as the number of occurrence (entropy factor) for the cisplatinum compound point to a preferredTBP TSC geometry with NH3 and Cl in axial positions. However, foren and substituteden compounds,TSCs withSP geometries (Cl in apical position) are preferred. The calculatedEH andMM energies of theTBP andSP structures do not differ significantly andTBP ↔SP interconversions may play an essential role inTSC formation. To improve the discrimination, theMM-optimized geometries were treated in terms of displacement coordinates for D3h (TBP) and C4v (SP) by calculating the total distortion vectors (DV).DV identified once again theTBP with NH3 and Cl in axial position as the least-distorted conformer, but it also revealed the combinations of displacement coordinates which shape theTSC geometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806855
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    1,3-Diphenylpropane-1,3-diamines, X: Synthesis and biochemical evaluation of highly substituted 1,3-diphenylpropane-1,3-diamines and preparation of their Pt(II) complexes (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 1073-1080 
    Details
    ISSN: 1434-4475
    Keywords: 1,3-Diphenylpropane-1,3-diamines ; Receptor binding affinity ; Estrogenic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Liganden der Titelverbindungen1 und2 wurden aus dem entsprechenden Chalcon5 mit Hydrazinhydrat und anschließende N-N-Spaltung hergestellt. Die oestrogene Wirkung der Diamine11 und12 wurde im Rezeptorbindungstest an Kalbsuterus-Zytosol und durch einen Luziferase-Test an MCF 7-2a-Zellen bestimmt. Die Verbindungen wirken viel schwächer alsSchönenbergers aktivste Substanz ([meso-1,2-Bis(2,6-dichlor-4-hydroxyphenyl)ethan-1,2-diamin]dichloro-Platin(II),3).
    Notes: Summary The ligands of the title complexes1 and2 were prepared from the pertinent chalcone5 and hydrazine hydrate, followed by N-N cleavage. The estrogenic activity of the diamines11 and12 was determined by measuring the RBA values (calf uterine cytosol) and by a luciferase test in MCF 7-2a cells. The compounds are by far less active thanSchönenberger's most active compound ([meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethane-1,2-diamine]dichloro-platinum(II),3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Investigations on the stability of bendamustin, a cytostatic agent of the nitrogen mustard type, I. Synthesis, isolation, and characterization of reference substances (1997)
    Springer
    Monatshefte für Chemie 128 (1997), S. 291-299 
    Details
    ISSN: 1434-4475
    Keywords: Bendamustin ; Antineoplastic ; Hydrolysis products ; Reference substances ; Spectroscopic characterization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die folgenden Verbindungen wurden als Vergleichssubstanzen für HPLC-analytische Untersuchungen von 4-(6-Bis(2-chlorethyl)amino-3-methylbenzimidazoyl(2))buttersäure (Bendamustin), einem Antitumormittel des N-lost-Typs, synthetisiert oder aus Bendamustin-Rohstoff vor der Endreinigung isoliert: (4-(6-((2-Chlorethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazoyl(2))buttersäure (HP1), 4-(6-Bis(2-hydroxyethyl)amino-3-methylbenzimidazoyl(2))buttersäure (HP2), 4-(6-Bis(2-hydroxyethyl)amino-3-methylbenzimidazoyl(2))buttersäureethylester (Dichlorester). Weiterhin konnte das bislang unbekannte Nebenprodukt 4-(7,8-Dihydro-6-(2-chlorethylamino)-3-methyl-1,4-thiazino[3,2-g]benzimidazoyl(2))buttersäure (NP1), welches sich im letzten Schritt der Synthese bildet, isoliert und identifiziert werden.
    Notes: Summary The following compounds were chosen as reference substances for HPLC investigations on 4-(6-bis(2-chloro-ethyl)amino-3-methylbenzimidazoyl(2))butyric acid (bendamustin), an antineoplastic agent of the N-lost type (synthesized or isolated from crude bendamustin): 4-(6-((2-chloroethyl)(2-hydroxyethyl)amino)-3-methylbenzimidazoyl(2))butyric acid (HP1), 4-(6-bis(2-hydroxyethyl)amino-3-methylbenzimidazoyl(2))butyric acid (HP2), ethyl-4-(6-bis(2-hydroxyethyl)amino-3-methylbenzimidazoyl(2))butyrate (dihydroxyester), and ethyl-4-(6-bis(2-chloroethyl)amino-3-methylbenzimidazoyl(2))butyrate (dichloroester). Furthermore, the so far unidentified side product 4-(7,8-dihydro-6-(2-chloroethylamino)-3-methyl-1,4-thiazino[3,2-g]benzimidazoyl(2))-butyric acid (NP1), formed in the last step of the synthesis, was isolated and identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807895
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...