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  • 1995-1999  (3)
  • Key words Cartilage  (1)
  • Kontrastmittel  (1)
  • Osteosarcoma  (1)
  • chemotherapy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Can conventional radiographs be used to monitor the effect of neoadjuvant chemotherapy in patients with osteogenic sarcoma? (1996)
    Springer
    Skeletal radiology 25 (1996), S. 19-24 
    Details
    ISSN: 1432-2161
    Keywords: Key words Bone tumour ; Bone neoplasm ; Conventional radiography ; Chemotherapy ; Osteosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. The objective of this study was to assess the effectiveness of conventional radiography in predicting histopathologic response in patients with osteogenic sarcoma who were treated with preoperative chemotherapy. Design and patients. The radiographs of 22 patients with an osteogenic sarcoma, taken before and after neoadjuvant chemotherapy, were reviewed. Tumour location, size, radiographic appearance, margination, cortical destruction and periosteal reaction were evaluated. The findings were correlated with the histopathologic response of the surgical specimen. Results. None of the findings proved to be of predictive value for the histopathologic response. Increase in tumour diameter and increase in ossification and/or calcification, which were seen in more than half of the patients, did not correlate with response. Conclusion. Conventional radiographs do not contribute to the identification of good or poor responders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050026
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Maligne Knorpeltumoren (1998)
    Springer
    Der Radiologe 38 (1998), S. 502-508 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Chondrosarkom ; Radiologische Diagnose ; Magnetresonanztomographie (MRI) ; Kontrastmittel ; Key words Cartilage ; Sarcoma ; Diagnostic radiology ; Magnetic resonance (MR) ; contrast agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Malignant cartilaginous tumors (chondrosarcomas) are, with a relative frequency of 20%, the second most common malignant tumors of bone after osteosarcoma. The diagnosis of chondrosarcoma can usually be made confidently based on combination of clinical information, radiographs, Gd-enhanced MR imaging, and histologic examination of a biopsy sample. The combination of these parameters is important because accuracy of histologic diagnosis is adversely affected by unrepresentative sampling of these usually large tumors. The prognosis of patients with chondrosarcoma becomes poorer with more axial location, higher histologic grade, larger tumor size and inadeqaute resection. By careful analysis of radiographs and Gd-enhanced MR imaging the radiologist has the ability to improve the management of patients with chondrosarcoma.
    Notes: Zusammenfassung Die malignen Knorpeltumoren oder Chondrosarkome treten in einer Inzidenz von 20% auf und sind damit die zweithäufigsten primären malignen Tumoren des Knochens nach dem Osteosarkom. Üblicherweise kann in Zusammenschau von klinischer Information, Nativröntgenbildern und Kontrastmittel-MR-Untersuchung sowie Histologie eine zuverlässige Diagnose gestellt werden. Es ist wichtig, alle diese Modalitäten in ihrer Gesamtheit zu betrachten, da die Histologien manchmal durch nichtrepräsentative Gewebsentnahmen aus diesen oft großen Tumoren ungenau sind. Die Prognose von Chondrosarkomen verschlechtert sich bei stammnaher Lokalisation, hohem Grading, zunehmender Tumorgröße und insuffizienter Resektion. Durch sorgfältige Interpretation von Röntgenaufnahmen und MR-Kontrastmitteluntersuchungen liegt es in der Hand des Radiologen die Behandlung von Chondrosarkompatienten zu optimieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050385
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A phase II study of cisplatin, ifosfamide and doxorubicin in operable primary, axial skeletal and metastatic osteosarcoma (1999)
    Springer
    Annals of oncology 10 (1999), S. 1211-1218 
    Details
    ISSN: 1569-8041
    Keywords: chemotherapy ; osteosarcoma ; relative dose intensity ; survival ; tumour response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Despite advances in the treatment of primary limb osteosarcoma, the outcome of patients with primary metastatic and axial skeletal disease remains poor. The European Osteosarcoma Intergroup have assessed a combination chemotherapy regimen consisting of ifosfamide (IFOS) 3 g/m2/d1–2, doxorubicin (DOX) 25 mg/m2/d1–3 i.v. bolus and cisplatin (CDDP) 100 mg/m2/d1. Patients and methods: One hundred nine previously untreated patients with primary osteosarcoma were registered. Eligibility was confirmed in 103. At presentation, 45 eligible patients had metastatic disease, 15 axial skeletal primary tumours and 43 non-metastatic limb tumours. Results: The major toxicities were myelosuppression (90%, grade 3 or 4) and nausea and vomiting (74%, grade 3 or 4). Overall mean relative dose intensity (RDI) was 80% (88% CDDP, 75% IFOS, 81% DOX). Clinical response as measured by reduction in tumour volume occurred in 36% (95% confidence interval (95% CI): 27%–47%) of primary tumours. Response of pulmonary metastases to chemotherapy was seen in 33% (95% CI: 19%–49%). Good histological response (≥90% necrosis of the tumour) occurred in 33% (95% CI: 22%–45%) of resected tumours. Five-year survival was 62% in limb-non-metastatic, 41% in axial skeletal and 16% in limb metastatic patients. Conclusions: This regimen is active in osteosarcoma but does not appear to be more active than the two-drug CDDP–DOX regimen currently recommended by EOI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008361612767
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    Paper (German National Licenses)
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