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  • 1
    Electronic Resource
    Electronic Resource
    Creatine kinase activity in the detection of carriers of Duchenne muscular dystrophy: comparison of two methods
    Amsterdam : Elsevier
    Clinica Chimica Acta 121 (1982), S. 345-359 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(82)90244-3
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Low Spin Ferrous Iron in the Iron Silicate Deerite (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 1389-1389 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Deerite was separated from a sample from the type locality, Laytonville, California. The chemical analysis is listed below in Table 1. The formula is appproximately Fe213Fe37Si13O44(OH)11 with minor substitution of titanium and aluminium for ferric iron and manganese for ferrous iron. The inverse ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2111389a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Oxidation of Transition Metals in Molten Lithium Chloride–Potassium Chloride Eutectic by Mercuric Chloride (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 966-967 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] From the available redox potentials in the lithium chloride/potassium chloride eutectic, in principle, a number of reactants are capable of oxidizing the transition metals and a preliminary survey using chlorine, mercuric chloride, mercurous chloride and silver chloride was carried out. All the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211966a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The hepato-renal syndrome of cultured turbot. Its effect on a 2-year trial of farm reared turbot (Scophthalmus maximus)
    Amsterdam : Elsevier
    Aquaculture 8 (1976), S. 241-249 
    Details
    ISSN: 0044-8486
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0044-8486(76)90086-7
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Virtual conferencing (1997)
    Springer
    BT technology journal 15 (1997), S. 120-129 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Current multi-party video- and audioconferencing systems limit natural communications between participants. People communicate by speech, facial expressions and body gestures. In interactions between three or more people, these communications channels are directed towards particular participants. Spatial proximity and gaze direction are therefore important elements for effective conversational interactions, and yet are largely unsupported in existing conferencing tools. Advanced audioconferencing systems do simulate presence in a shared environment by using ‘virtual humans’ to represent the people taking part in a meeting, but the keyboard and mouse are used to direct conversations to specific people or to change the visual representation to simulate emotion. This paper describes an experimental implementation of virtual conferencing, which uses machine vision to control a realistic virtual human, with the objective of making ‘virtual meetings’ more like physical ones. The computer vision system provides a more natural interface to the environment, while the realistic representation of users, with appropriate facial gestures and upper body movement, gives more natural visual feedback.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018687630541
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A phase II study of cisplatin, ifosfamide and doxorubicin in operable primary, axial skeletal and metastatic osteosarcoma (1999)
    Springer
    Annals of oncology 10 (1999), S. 1211-1218 
    Details
    ISSN: 1569-8041
    Keywords: chemotherapy ; osteosarcoma ; relative dose intensity ; survival ; tumour response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Despite advances in the treatment of primary limb osteosarcoma, the outcome of patients with primary metastatic and axial skeletal disease remains poor. The European Osteosarcoma Intergroup have assessed a combination chemotherapy regimen consisting of ifosfamide (IFOS) 3 g/m2/d1–2, doxorubicin (DOX) 25 mg/m2/d1–3 i.v. bolus and cisplatin (CDDP) 100 mg/m2/d1. Patients and methods: One hundred nine previously untreated patients with primary osteosarcoma were registered. Eligibility was confirmed in 103. At presentation, 45 eligible patients had metastatic disease, 15 axial skeletal primary tumours and 43 non-metastatic limb tumours. Results: The major toxicities were myelosuppression (90%, grade 3 or 4) and nausea and vomiting (74%, grade 3 or 4). Overall mean relative dose intensity (RDI) was 80% (88% CDDP, 75% IFOS, 81% DOX). Clinical response as measured by reduction in tumour volume occurred in 36% (95% confidence interval (95% CI): 27%–47%) of primary tumours. Response of pulmonary metastases to chemotherapy was seen in 33% (95% CI: 19%–49%). Good histological response (≥90% necrosis of the tumour) occurred in 33% (95% CI: 22%–45%) of resected tumours. Five-year survival was 62% in limb-non-metastatic, 41% in axial skeletal and 16% in limb metastatic patients. Conclusions: This regimen is active in osteosarcoma but does not appear to be more active than the two-drug CDDP–DOX regimen currently recommended by EOI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008361612767
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  • 7
    Electronic Resource
    Electronic Resource
    True-view Videoconferencing System Through 3-D Impression of Telepresence (1999)
    Springer
    BT technology journal 17 (1999), S. 59-68 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract It can be argued that an ideal teleconferencing system would offer a sense of presence comparable to that afforded by real face-to-face meetings. In contrast, traditional desktop videoconferencing loses essential socially important phenomena such as true perspective views, live facial expressions and tacit body language. This paper reports a prototype concept demonstrator under development at BT Laboratores that addresses these issues in order to make the use of videoconferencing a normal social activity rather than a means of merely getting messages across the channel. The idea is to place participants from different remote sites in a coherent virtual environment naturally extended from the real world. The participants have correct views of each other and the illusion of close proximity. The rationale is to build on the demonstrator and enhance it with increasingly realistic functional components as the relevant technical solutions become available. Results are presented of a stereo-based vision system which can synthesise novel (or virtual camera) perspective views of the scene from two fixed camera views. The technique is currently capable of providing 'look-around' views and a certain degree of navigation capability around the scene. Research issues are discussed together with the practical difficulties that remain to be solved in implementing a true-view, telepresence, videoconferencing system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009670824102
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  • 8
    Electronic Resource
    Electronic Resource
    Guidelines for reporting results of quality of life assessments in clinical trials (1996)
    Springer
    Quality of life research 5 (1996), S. 496-502 
    Details
    ISSN: 1573-2649
    Keywords: Clinical trials ; guidelines ; health-related quality of life ; quality of life ; reporting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical trials involving quality of life measurement published in the literature suffer from important weaknesses due to the lack of information on numerous topics. The psychometric properties of the instruments are often lacking as well as data on the number of patients treated and analyzed. The handling of missing data is rarely documented. In order to facilitate the reporting of trials and the evaluation of published results, this article proposes a set of general guidelines for the reporting of clinical trials which include a quality of life assessment. A checklist designed to assist authors is appended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540022
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Approaches to the analysis of quality of life data: experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial (1994)
    Springer
    Quality of life research 3 (1994), S. 339-352 
    Details
    ISSN: 1573-2649
    Keywords: Attrition ; compliance ; lung cancer ; missing values ; psychological data ; quality of life ; randomised trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Standardization in the choice of quality of life (QOL) instruments and their application in randomised clinical trials have been advocated and generally accepted. However, there is now an urgent need to address the problems relating to the analysis and presentation of the data thus generated. There are intrinsic difficulties associated with QOL data, namely its multidimensional nature, attrition and missing data, and there is no consensus as to how these problems should be dealt with. This paper therefore considers there problems using interim data from a large Medical Research Council randomised trial in patients with small cell lung cancer and a poor prognosis, in which attrition and compliance are major concerns. Three possible approaches to the analysis of these data, which use different subsets of patients, are examined in detail. The strengths and weaknesses of these three methods are discussed, and examples of their use in the literature are given and compared with other reported approaches. The need for a standard definition of compliance is also emphasised, and a method of presentation suggested. The best current advice is that QOL data should be analysed in a number of different ways, and conclusions reached only when consistency is seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451726
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  • 10
    Electronic Resource
    Electronic Resource
    Quality of life of Danish women: Population-based norms for the EORTC QLQ-C30 (1997)
    Springer
    Quality of life research 6 (1997), S. 0-0 
    Details
    ISSN: 1573-2649
    Keywords: EORTC-QLQ-C30 ; breast cancer ; gynaecological cancer ; norms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to derive population-based norms for women completing the EORTC QLQ-C30 version 1 which is designed for use with patients who have cancer. The study was conducted using two different questionnaires: one designed for use in female patients with breast cancer, the other for those with gynaecological cancers, but both including the EORTC QLQ-C30. The women were drawn from the Danish Central Population Register without knowledge of their health status and divided at random between the two questionnaires. All procedures for collecting data were identical. The response rate for those receiving the gynaecological cancer (GS) questionnaire was 49% and it was 71% for the breast cancer (BS) questionnaire. Detailed comparison between the two samples revealed several EORTC QLQ-C30 items showing a clear difference in distribution of scores between them. Because of this and the possible bias due to the relative low age-related response rate in GS, only the results from the BS are used for constructing norms. The norms cover all 30 single items on the EORTC QLQ-C30 and the nine derived scales, for women in four 10-year age groups commencing at 30 years and for those aged 70-75. Clear trends in, for example, declining ability to undertake strenuous activity are illustrated and quantified. Levels of certain symptoms, such as pain, are surprisingly high although it is recognized that the population sampled will contain a proportion of women with active disease including cancer. We recommend the use of these norms both as an aid to the clinical assessment of an individual patient, and to assist in the interpretation of clinical trial and longitudinal quality of life data. As a secondary result, we note that a population-based sample will have a lower response rate to a questionnaire with more questions, especially if many of these extra questions are on sexual issues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026461310761
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