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  • 1995-1999  (6)
  • United States  (4)
  • Knee  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Extraskeletal myxoid chondrosarcoma of the knee (1999)
    Springer
    Skeletal radiology 28 (1999), S. 354-358 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Extraskeletal myxoid chondrosarcoma ; Metastasis ; Kidney ; Pancreas ; Chemotherapy ; Knee
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Extraskeletal myxoid chondrosarcoma is an uncommon neoplasm, accounting for less than 2% of all soft tissue sarcomas. It affects adult males with a median age in the fifth decade at the time of diagnosis. The tumor usually arises in the deep soft tissues, especially in the lower extremities. Patients present with a gradually enlarging mass that may or may not be associated with pain. This report describes a 25-year-old man who initially presented with a 4- to 5-year history of right knee pain and an enlarging mass in the right knee. Evaluation revealed a cartilaginous neoplasm with no evidence of metastatic disease. The tumor was widely excised and an allograft reconstruction was performed. The patient was closely followed with an eventual above the knee amputation for recurrent myxoid chondrosarcoma. At 34 months, retroperitoneal metastases were noted on abdominal CT. The patient underwent a left radical nephrectomy, renal vein thrombectomy and enucleation of the mass in the right kidney, distal pancreatectomy, and splenectomy. The patient received postoperative chemotherapy. Forty-eight months after initial diagnosis, the patient was found to have recurrent abdominal and retroperitoneal lesions. At 64 months, the patient died from complications of extraskeletal myxoid chondrosarcoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050531
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  • 2
    Digitale Medien
    Digitale Medien
    Chondrocalcinosis of the hyaline cartilage of the knee: MRI manifestations (1998)
    Springer
    Skeletal radiology 27 (1998), S. 369-374 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Key words Calcium pyrophosphate dihydrate (CPPD) deposition disease ; Chondrocalcinosis ; Knee ; MRI ; Cartilage ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Purpose. To determine the ability of MRI to detect the presence of crystals of calcium pyrophosphate in the articular cartilage of the knee. Design and patients. The MR studies of 12 knees (11 cases) were reviewed retrospectively and correlated with radiographs (12 cases) and the findings at arthroscopy (2 cases) and surgery (1 case). A total of 72 articular surfaces were evaluated. Radiographic, surgical or arthroscopic demonstration of chondrocalcinosis was used as the gold standard. Additionally, two fragments of the knee of a patient who underwent total knee replacement and demonstrated extensive chondrocalcinosis were studied with radiography and MRI using spin-echo T1-, T2- and proton-density-weighted images as well as two- and three-dimensional fat saturation (2D and 3D Fat Sat) gradient recalled echo (GRE) and STIR sequences. Results. MRI revealed multiple hypointense foci within the articular cartilage in 34 articular surfaces, better shown on 2D and 3D GRE sequences. Radiographs showed 12 articular surfaces with chondrocalcinosis. In three cases with arthroscopic or surgical correlation, MRI demonstrated more diffuse involvement of the articular cartilage than did the radiographs. The 3D Fat Sat GRE sequences were the best for demonstrating articular calcification in vitro. In no case was meniscal calcification identified with MRI. Hyperintense halos around some of the calcifications were seen on the MR images. Conclusion. MRI can depict articular cartilage calcification as hypointense foci using GRE techniques. Differential diagnosis includes loose bodies, post-surgical changes, marginal osteophytes and hemosiderin deposition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002560050400
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  • 3
    Digitale Medien
    Digitale Medien
    Oral contraceptive use and breast cancer risk among African-American women (1995)
    Springer
    Cancer causes & control 6 (1995), S. 321-331 
    Details
    ISSN: 1573-7225
    Schlagwort(e): Blacks ; breast carcinoma ; oral contraceptives ; United States
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Recent epidemiologic studies, most of them in predominantly White populations, have suggested that long duration of oral contraceptive (OC) use may increase the risk of breast cancer at young ages. We assessed the relationship of OC use to the risk of breast cancer in African-American women aged 25 to 59 years, using interview data from a multipurpose hospital-based case-control study. Five hundred and twenty-four cases hospitalized for invasive breast cancer were compared with 1,021 controls with nonmalignant conditions unrelated to OC use. Relative risks (RR) and 95 percent confidence intervals (CI) were estimated relative to a reference category of use for less than 12 months; potential confounders were controlled by multiple logistic regression analysis. Among women under age 45, three or more years of OC use was associated with an increased risk of breast cancer: the RR estimate was 2.8 (CI=1.5–5.0) for three to four years of use, and declined to 1.5 (CI=0.8.3.0) for 10 or more years of use. Recency and timing of use did not explain the observed association. Among women aged 45 to 59, OC use was associated with little or no increase in risk: the RR estimate for three or more years of use was 1.3 (CI=0.7–2.4). The findings add to the evidence from studies of White women and a recent study of Black women which have suggested an increased risk of breast cancer at young ages for moderate or long duration use of OCs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00051407
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  • 4
    Digitale Medien
    Digitale Medien
    Parental ages at birth in relation to a daughter's risk of breast cancer among female participants in the Framingham study (United States) (1995)
    Springer
    Cancer causes & control 6 (1995), S. 23-29 
    Details
    ISSN: 1573-7225
    Schlagwort(e): Breast neoplasms ; cohort study ; daughters ; maternal age ; paternal age ; United States
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Data from the Framingham Heart Study, collected in Framingham, MA (United States) during 1948–86, were used to evaluate the relation of parental age at birth to the risk of breast cancer among daughters. After 38 years of follow-up, 149 breast cancer cases occurred among 2,662 women. All but two cases were confirmed by histologic report. The rate of breast cancer increased among daughters with increasing maternal age at birth up to the mid-30s, where the rate levelled off. A similar pattern was observed with paternal age. After adjustment for other confouding factors and paternal age, the rate ratios for breast cancer in daughters whose mothers were aged 26 to 31 years and 32 or more years at their birth, relative to women whose mothers were aged 25 years or younger, were 1.5 (95 percent confidence interval [CI]=1.0–2.4) and 1.3 (CI=0.8–2.2), respectively. However, there was no longer an association between paternal age at birth and risk of breast cancer after controlling for maternal age and other risk factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00051677
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  • 5
    Digitale Medien
    Digitale Medien
    Transitional cell cancer of the urinary tract and renal cell cancer in relation to acetaminophen use (United States) (1998)
    Springer
    Cancer causes & control 9 (1998), S. 83-88 
    Details
    ISSN: 1573-7225
    Schlagwort(e): Acetaminophen ; kidney neoplasms ; renal cell carcinoma ; United States
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Experimental and epidemiologic evidence have suggested that phenacetin use increases the risk of transitional cell cancers of the urinary tract. The drug is no longer marketed but a commonly used metabolite, acetaminophen, has been linked recently to an increased risk of renal cancer. We assessed the relation of acetaminophen use to the risk of transitional cell cancer of the urinary tract and of renal cell cancer with data from a hospital-based study of cancers and medication use conducted from 1976-96 in the eastern United States. We compared 498 cases of transitional cell cancer and 383 cases of renal cell cancer with 8,149 noncancer controls and 6,499 cancer controls and controlled confounding factors with logistic regression. For transitional cell cancer, the relative risk (RR) estimate for regular acetaminophen use that had begun at least a year before admission was 1.1 (95 percent confidence interval [CI] = 0.6-1.9) based on noncancer controls, and 0.9 (CI = 0.5-1.6) based on cancer controls. RR estimates for use that lasted at least five years, and for nonregular use, were also close to 1.0. For renal cell cancer, the corresponding estimates were again close to 1.0. Our results suggest that acetaminophen, as used in present study population, does not influence the risk of transitional cell cancer of the urinary tract or of renal cell cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008805505154
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  • 6
    Digitale Medien
    Digitale Medien
    Induced and spontaneous abortion in relation to risk of breast cancer (United States) (1997)
    Springer
    Cancer causes & control 8 (1997), S. 841-849 
    Details
    ISSN: 1573-7225
    Schlagwort(e): Abortion ; breast carcinoma ; risk factors ; United States ; women
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The relation of induced and spontaneous abortion to the risk of breast cancer is evaluated in a hospital-based case-control interview study conducted in three cities in the United States from 1985 through 1995. Cases were 1,803 women aged 25 to 64 years with newly diagnosed invasive breast cancer; controls were 4,182 women of the same ages admitted for conditions unrelated to reproductive factors. Other breast cancer risk-factors were controlled through multiple logistic regression. The reference for allanalyses was women who had never had an abortion, either induced or spontaneous. Among parous women, the relative risk (RR) estimate was 1.1 (95percent confidence interval [CI] = 0.9-1.5) for induced abortion overall, 1.0(CI = 0.7-1.4) for abortion before the first birth, and 1.3 (CI = 1.0-1.8)for abortion after at least one birth. Among nulliparous women, the relative risk estimate for induced abortion was 1.3 (CI = 0.9-1.9). There was no trend of increased risk with number of abortions, nor was there consistent evidence of an increased risk in any particular subgroup. Spontaneous abortion was not associated with increased risk of breast cancer, either among nulliparous women or among parous women. These findings provide little support for the hypothesis that induced abortion increases breast cancer risk overall or in particular subgroups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018408211089
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