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  • 1
    Electronic Resource
    Electronic Resource
    Congenital skin Bstula with sternal cleft (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb08700.x
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  • 2
    Electronic Resource
    Electronic Resource
    Prediction of the clinical and histological severity of IgA nephropathy by flow cytometry of urinary mononuclear cells (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 272-278 
    Details
    ISSN: 1437-7799
    Keywords: Key words Urinary mononuclear cells ; IgA nephro-pathy ; Flow-cytometry ; cellular immunity ; Clinico-histopathological correlations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Urinary mononuclear cells (UMCs) were studied in IgA nephropathy (IgAN) in relation to clinical and histopathological parameters. Methods. A two-color flow-cytometry analysis was used to phenotype and quantitate UMCs in patients with IgAN (n = 37) and those with other kidney diseases (n = 27). Results. The IgAN patients had higher numbers of UMCs than the patients with other kidney diseases. Macrophages (CD14+; P 〈 0.0001) and T lymphocytes (CD3+; P = 0.0001; CD4+, P 〈 0.0001) were predominantly found. In the IgAN patients, the quantities of urinary CD3+, CD14+ cells correlated with impaired renal function; namely, serum creatinine, creatinine clearance, and urinary protein excretion. The UMCs were associated with histopathological changes such as glomerular segmental lesions (r = 0.511; P 〈 0.01 for CD3+; r = 0.623, P 〈 0.0001 for CD4+, and r = 0.552; P 〈 0.001 for CD14+) and the index of glomerular hypercellularity (r = 0.405; P = 0.01 for CD3+ T cells and r = 0.392, P = 0.01 for CD14+ macrophages). Moreover, the UMCs reflected the severity of pathology, as estimated by the glomerular score (r = 0.424; P 〈 0.01 for CD3+; r = 0.458; P 〈 0.01 for CD4+; r = 0.500, P = 0.001 for CD14+ cells). UMCs were weakly correlated with tubulointerstitial changes. Conclusion. UMCs were associated with the clinical stage of IgAN and mirrored the extent of histopathology in the kidney. Flow-cytometry analysis of UMCs may help to predict the course of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050047
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of glycated collagen on proliferation of human smooth muscle cells in vitro (1996)
    Springer
    Diabetologia 39 (1996), S. 800-806 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Smooth muscle cell ; collagen ; aminoguanidine ; glycation ; atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While non-enzymatic glycation of long-lived tissue proteins such as collagen has been implicated in chronic complications of diabetes mellitus, its role in the aetiology of diabetic macroangiopathy has not been elucidated. To test the hypothesis that glycation of collagen abolishes the inhibitory effect of native collagen on the proliferation of human smooth muscle cells, we obtained smooth muscle cells from human gastric arteries and cultured them on dishes coated with glycated or non-glycated collagen. The proliferation of human smooth muscle cells in the presence of 10 % fetal calf serum or platelet derived growth factor-BB (10 ng/ml) was inhibited by type 1 collagen coated on the dishes. Glycation of collagen with glucose 6-phosphate for 7 days abolished the growth-inhibitory effect of native collagen. Succinylation of collagen, which like glycation blocked the lysyl residues in collagen, also abolished the growth-inhibitory effect. Adhesion of human smooth muscle cells to collagen-coated dishes was not affected by glycation of collagen. Addition of glycated albumin to the medium did not affect the growth of human smooth muscle cells on plastic dishes. The inhibition of human smooth muscle cell proliferation by collagen was not reversed by the glycation of collagen in the presence of aminoguanidine. Results suggest that early glycation abolishes the inhibitory effect of collagen on human smooth muscle cell proliferation and may thus participate in the progression of macroangiopathy in diabetes. [Diabetologia (1996) 39: 800–806]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050513
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  • 4
    Electronic Resource
    Electronic Resource
    Association between a polymorphism in the angiotensin-converting enzyme gene and microvascular complications in Japanese patients with NIDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 97-102 
    Details
    ISSN: 1432-0428
    Keywords: Angiotensin-converting enzyme ; diabetes mellitus ; polymorphism ; nephropathy ; retinopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between diabetic nephropathy and an insertion (I)/deletion (D) polymorphism in intron 16 of the angiotensin-converting enzyme (ACE) gene is still under debate. The association of ACE gene polymorphism with nephropathy and retinopathy was therefore examined in 362 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) and 105 healthy control subjects. Distribution of the ACE genotype did not differ between healthy control subjects and diabetic patients without complications. However, the frequency of the D allele was significantly higher in the diabetic subjects with nephropathy than in those without (0.32 in normoalbuminuric patients vs 0.44 in albuminuria patients with albuminuria) (χ2=7.7; p=0.006). There was no significant association between ACE genotype and retinopathy. These observations thus demonstrate a significant association of the ACE gene polymorphism with nephropathy, but not with retinopathy, in Japanese patients with NIDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400419
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  • 5
    Electronic Resource
    Electronic Resource
    Rapidly growing esophageal leiomyosarcoma: case report and review of the literature (1995)
    Springer
    Abdominal imaging 20 (1995), S. 15-19 
    Details
    ISSN: 1432-0509
    Keywords: Esophagus ; Leiomyosarcoma, EUS, CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated a 72-year-old woman who was experiencing dysphagia. Esophageal leiomyosarcoma was diagnosed by barium meal study, upper gastrointestinal endoscopy, endoscopic ultrasonography (EUS), by computed tomography (CT). A barium meal study and esophagoscopy performed 3 months before the diagnosis of esophageal leiomyosarcoma showed no abnormalities. Therefore, the tumor appeared to have grown rapidly during the 3-month period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199635
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  • 6
    Electronic Resource
    Electronic Resource
    Sonographic detection of haemodynamic changes in a case of vertebrobasilar insufficiency (1998)
    Springer
    Neuroradiology 40 (1998), S. 164-166 
    Details
    ISSN: 1432-1920
    Keywords: Key words Vertebrobasilar insufficiency ; Compression ; arterial ; Ultrasonography ; Surgical decompression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a diagnostically challenging case of vertebrobasilar insufficiency caused by head rotation. The patient was a 58-year-old man complaining of dizziness and faintness with head rotation to the left. Vertebral arteriography with the head turned to the left revealed mechanical compression of the right vertebral artery at the occipitoatlantal joints and an occluded left vertebral artery. Duplex sonography demonstrated disappearance of the end-diastolic flow signal in the right vertebral artery on head rotation, paralleling the appearance of symptoms. Decompression of the vertebral artery by transversectomy of the atlas and hemilaminectomy of the axis completely relieved the symptoms and the Doppler flow signal pattern of the vertebral artery returned to normal: End-diastolic flow in the right vertebral artery did not disappear even when the head was rotated to the left.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050560
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  • 7
    Electronic Resource
    Electronic Resource
    Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis (1997)
    Springer
    Surgical endoscopy and other interventional techniques 11 (1997), S. 673 -675 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Rheumatoid arthritis — gastric outlet obstruction-pyloric stenosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe a 50-year-old Japanese woman with rheumatoid arthritis who presented with near-complete gastric outlet obstruction. The patient also suffered from secondary gastrointestinal and cardiac amyloidosis. Gastroscopy revealed multiple huge gastric antral ulcers in which amyloid deposits were identified on histologic examination. The ulcers became scars after treatment with omeprazole, which cause in severe pyloric stenosis. Endoscopic hydrostatic balloon dilation under fluoroscopic guidance was performed twice for 10 min. The pyloric outlet remained sufficiently patent 22 months later.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900420
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  • 8
    Electronic Resource
    Electronic Resource
    Endoscopic evaluation of gastric inflammatory fibroid polyp (1995)
    Springer
    Surgical endoscopy and other interventional techniques 9 (1995), S. 397-400 
    Details
    ISSN: 1432-2218
    Keywords: Gastric polyp ; Stomach ; Submucosal tumor ; Inflammatory fibroid polyp ; Endoscopy ; Endoscopic polypectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical and endoscopic manifestations of 18 gastric inflammatory fibroid polyps (IFP) in 16 patients who underwent endoscopic or surgical removal were retrospectively analyzed. All of the lesions were located within the pyloric antrum, and the sizes varied from 0.8 to 7.0 cm. On endoscopy, six polyps which measured 1.0 cm or less uniformly seemed to be sessile or intramural tumors, whereas four of the nine polyps between 1.1 and 2.0 cm in size were additionally accompanied by a central depression. The remaining three, which measured more than 2.0 cm, showed characteristic polypoid growth with ulcerations. Three polyps more than 1.0 cm in size occasionally prolapsed into the duodenal bulb. Three patients with these prolapsing polyps and two with polyps accompanied by ulcerations experienced abdominal pain, nausea, or severe anemia. Two polyps (11%) were precisely diagnosed as IFP by means of conventional forceps biopsy. Histological examinations revealed that all of the polyps proliferated within the submucosa. Therefore, this type of polyp may be subject to endoscopic removal to enable a precise diagnosis and treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187158
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  • 9
    Electronic Resource
    Electronic Resource
    Villous adenoma of the duodenum in a patient with familial adenomatosis coli (1995)
    Springer
    Surgical endoscopy and other interventional techniques 9 (1995), S. 512-514 
    Details
    ISSN: 1432-2218
    Keywords: Villous adenoma ; Familial adenomatosis coli (FAC) ; Gardner's syndrome ; Polypectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of familial adenomatosis coli with villous adenoma of the third portion of the duodenum, which falls in the category of a Gardner's syndrome, is described. The patient, who had complained of an abdominal mass which had been diagnosed as a desmoid tumor after surgical resection, had numerous adenomatous polyps throughout the colon confirmed by colonoscopy with biopsy. Endoscopic examination of the upper gastrointestinal tract revealed fundic gland polyposis in the stomach and numerous small adenomas in the duodenum. In addition, there was a pedunculated polyp in the third portion of his duodenum, measuring 30 mm in diameter, the surface of which had a cauliflowerlike appearance. The polyp was removed with the electrocautery snare and was histologically diagnosed as villous adenoma. Our case report supports the concept that villous adenoma, which possesses a high malignant potential, may occur in the upper gastrointestinal tract in patients with familial adenomatosis coli, and careful examination of the upper gastrointestinal tract including the distal duodenum seems to be necessary in the follow-up of patients with this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206838
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  • 10
    Electronic Resource
    Electronic Resource
    Possible neoplastic transformation within gastric hyperplastic polyp (1995)
    Springer
    Surgical endoscopy and other interventional techniques 9 (1995), S. 714-718 
    Details
    ISSN: 1432-2218
    Keywords: Gastric polyp ; Hyperplastic polyp ; Gastric cancer ; Endoscopic polypectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 263 gastric hyperplastic polyps, which had been removed endoscopically from 202 patients, were clinicopathologically analyzed. Among these polyps, there were nine polyps with neoplastic components (3.4%), corresponding to adenoma in five lesions and mucosal adenocarcinoma in four lesions. Comparing the neoplastic transformed polyps with the pure hyperplastic polyps, there was no significant difference according to age, gender, location, gross appearance, or size. However, the transformed polyps which were located in the lower third of the stomach were larger in size (mean, 20.8 mm) and were more likely to be found among older patients (mean, 75.8 years) than were the pure hyperplastic polyps (mean size and age: 14.5 mm and 61.8 years). These results may indicate the possibility of a different carcinogenesis belonging to gastric hyperplastic polyps by location, and this finding seems to be significant in the application of endoscopic polypectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187948
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