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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of antipyrine in rats with different resistance to hypoxia in cold stress (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 1098-1099 
    Details
    ISSN: 1573-8221
    Keywords: pharmacokinetics ; antipyrine ; individual resistance to hypoxia ; cold stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia. High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics under conditions of cold stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447243
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Activity of liver monooxygenase system in rats with low and high resistance to hypoxia (1996)
    Springer
    Bulletin of experimental biology and medicine 122 (1996), S. 906-908 
    Details
    ISSN: 1573-8221
    Keywords: liver monooxygenases ; resistance to hypoxia ; antipyrine ; nifedipine ; diazepam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Rats with low and high resistance to hypoxia are shown to differ in terms of the baseline activity of liver monooxygenases bothin vivo andin vitro. Low-resistance animals are characterized by a significantly higher rate of elimination of antipyrine, hexenal, and nifedipine, as evidenced by shorter half-elimination period and higher urinary concentration of metabolites. The concentration of microsomal cytochromes P-450 and b5 as well as the rates of N-demethylation of amidopyrine, p-hydroxylation of aniline, and hydroxylation of diazepam are considerably higher in rats with low resistance to hypoxia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446578
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Biotransformation of hepatic xenobiotics in rats with various resistance to hypoxia exposure to after cold (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 1203-1204 
    Details
    ISSN: 1573-8221
    Keywords: individual resistance to hypoxia ; hepatic monooxygenases ; cold ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure. However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447150
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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